text s9: yellow/major royal jelly protein family
... using RAxML v7.2.6 [10]. Nodal support values were obtained by the rapid bootstrap algorithm as implemented in RAxML (500 replicates). The tree (Fig. 1) reveals twelve gene subfamilies within insect yellow/MRJP genes, most of which are characterized by a one-to-one orthologous relationship among th ...
... using RAxML v7.2.6 [10]. Nodal support values were obtained by the rapid bootstrap algorithm as implemented in RAxML (500 replicates). The tree (Fig. 1) reveals twelve gene subfamilies within insect yellow/MRJP genes, most of which are characterized by a one-to-one orthologous relationship among th ...
Mutator Transposon in Maize and MULEs in the Plant Genome
... may have had a significant impact on host genome evolution. There is also evidence that MULEs can move between reproductively isolated species. Here we present an overview of the discovery, features and utility of Mu transposon. Classification of Mu elements and future directions of related research ...
... may have had a significant impact on host genome evolution. There is also evidence that MULEs can move between reproductively isolated species. Here we present an overview of the discovery, features and utility of Mu transposon. Classification of Mu elements and future directions of related research ...
Bioinformatics
... Indicate limitations of ortholog-classification methods that are based only on BLAST comparisons. Should consider more than just base or amino acid differences. Synonymous changes are less significant than non-synonymous and conservative changes less significant than non-conservative. Does not a ...
... Indicate limitations of ortholog-classification methods that are based only on BLAST comparisons. Should consider more than just base or amino acid differences. Synonymous changes are less significant than non-synonymous and conservative changes less significant than non-conservative. Does not a ...
Document
... • To find genes involved in a particular process, we can look for mRNAs “up-regulated” during that process. • For example, we can look at genes up-regulated in human cells in response to cancer-causing mutations, or look at genes in a crop plant responding to drought. ...
... • To find genes involved in a particular process, we can look for mRNAs “up-regulated” during that process. • For example, we can look at genes up-regulated in human cells in response to cancer-causing mutations, or look at genes in a crop plant responding to drought. ...
Overlapping gene structure of human VLCAD and
... 6 at 11B3 – B4 in a head-to-head orientation. In contrast to the human genes, the mouse genes do not overlap and contain a gap of 3.48 kb between them. This suggests that the VLCAD and DLG4 genes were originally separated but have become co-localized during the course of evolution. Further analysis ...
... 6 at 11B3 – B4 in a head-to-head orientation. In contrast to the human genes, the mouse genes do not overlap and contain a gap of 3.48 kb between them. This suggests that the VLCAD and DLG4 genes were originally separated but have become co-localized during the course of evolution. Further analysis ...
DNA damage, repair and recombination
... length and comprise a transposase gene flanked by short (~20 bp) inverted terminal repeats (identical sequences but with opposite orientation). The transposase makes a staggered cut in the chromosomal DNA and, in a replicative process, a copy of the transposon inserts at the target site The gaps are ...
... length and comprise a transposase gene flanked by short (~20 bp) inverted terminal repeats (identical sequences but with opposite orientation). The transposase makes a staggered cut in the chromosomal DNA and, in a replicative process, a copy of the transposon inserts at the target site The gaps are ...
Phenomena of Life and Death Based on Nonphysical Gene and
... double helix by Francis Crick and James D. Watson in 1953 and in vitro characterization of the process of protein biosynthesis led to the idea that it was the linear sequence of ribonucleic acid derived from one of the DNA strands that directed the synthesis of a linear sequence of amino acids, or a ...
... double helix by Francis Crick and James D. Watson in 1953 and in vitro characterization of the process of protein biosynthesis led to the idea that it was the linear sequence of ribonucleic acid derived from one of the DNA strands that directed the synthesis of a linear sequence of amino acids, or a ...
Microarrays - Computational Bioscience Program
... – Probes are attached to a substrate in a known location – DNA/RNA in one or more samples are fluorescently labelled – samples are hybridized to probe array, excess is washed off, and fluorescence reading are taken for each position ...
... – Probes are attached to a substrate in a known location – DNA/RNA in one or more samples are fluorescently labelled – samples are hybridized to probe array, excess is washed off, and fluorescence reading are taken for each position ...
Dr. Hieter`s Lecture
... • 425 open reading frames were identified that displayed cell-cycle dependent fluctuations in transcript levels. • 40% were of unknown function. • 30% are located next to other cell-cycle transcribed genes (possible enhancer effect). • Correlation with known and unknown promoter elements. ...
... • 425 open reading frames were identified that displayed cell-cycle dependent fluctuations in transcript levels. • 40% were of unknown function. • 30% are located next to other cell-cycle transcribed genes (possible enhancer effect). • Correlation with known and unknown promoter elements. ...
Genetics and Evolution IB 201 06
... homeotic genes— genes whose products provide positional information in a multicellular embryo; these genes act within cells to select their developmental fate (selector genes); they regulate the overall body plan and determine the number, identity and pattern of body parts. Mutations in homeotic gen ...
... homeotic genes— genes whose products provide positional information in a multicellular embryo; these genes act within cells to select their developmental fate (selector genes); they regulate the overall body plan and determine the number, identity and pattern of body parts. Mutations in homeotic gen ...
Analysis of immunoglobulin heavy chain V
... V1O2.1 appears to exhibit sequences which interfere with the replication of M13. This may explain why gene V102.1 could not be isolated from a M13 library of B1-8.V1 derived genomic PstlBglll fragments. Although we restricted our analysis to VH-region genes located on size selected fragments flanked ...
... V1O2.1 appears to exhibit sequences which interfere with the replication of M13. This may explain why gene V102.1 could not be isolated from a M13 library of B1-8.V1 derived genomic PstlBglll fragments. Although we restricted our analysis to VH-region genes located on size selected fragments flanked ...
Genomics presentation
... part of the transcription process à topoisomerase Topoisomerase 2B inhibitors (etoposide) spark off therapy-related second cancers Etoposide ...
... part of the transcription process à topoisomerase Topoisomerase 2B inhibitors (etoposide) spark off therapy-related second cancers Etoposide ...
Models for Structural and Numerical Alterations in Cancer
... Models with multiple gene copies • Most models with multiple gene copies are NP-hard. • Not many models allow duplications or deletions. • Many normal and cancer genomes have multiple gene copies. ...
... Models with multiple gene copies • Most models with multiple gene copies are NP-hard. • Not many models allow duplications or deletions. • Many normal and cancer genomes have multiple gene copies. ...
Go Enrichment analysis using goseq 2014
... GO terms provide a standardized vocabulary to describe genes and gene products from different species. GO terms allow us to assign functionality to genes. The following properties are described for gene products: cellular component, describes where in a cell a gene acts, what cellular unit the gene ...
... GO terms provide a standardized vocabulary to describe genes and gene products from different species. GO terms allow us to assign functionality to genes. The following properties are described for gene products: cellular component, describes where in a cell a gene acts, what cellular unit the gene ...
Engineering Programmable Nucleases: Applications in the Study of
... We have constructed an archive of characterized zinc finger modules can be assembled into ZFPs to recognize a specific “address” within the genome ...
... We have constructed an archive of characterized zinc finger modules can be assembled into ZFPs to recognize a specific “address” within the genome ...
Array comparative genomic hybridization (array
... needs of the child, to access relevant services and support groups, and to make informed decisions about further children. Both groups also benefit from ending the uncertain, lengthy and often costly ‘diagnostic odyssey’. ...
... needs of the child, to access relevant services and support groups, and to make informed decisions about further children. Both groups also benefit from ending the uncertain, lengthy and often costly ‘diagnostic odyssey’. ...
Topic 3: Genetics (18 hours)
... Nature of science: Looking for patterns, trends and discrepancies—Mendel used observations of the natural world to find and explain patterns and trends. Since then, scientists have looked for discrepancies and asked questions based on further observations to show exceptions to the rules. For example ...
... Nature of science: Looking for patterns, trends and discrepancies—Mendel used observations of the natural world to find and explain patterns and trends. Since then, scientists have looked for discrepancies and asked questions based on further observations to show exceptions to the rules. For example ...
Whose DNA was sequenced for the Human Genome Project?
... number of gene family members has expanded in humans, especially in proteins involved in development and immunity. The human genome has a much greater portion (50%) of repeat sequences than the mustard weed (11%), the worm (7%), and the fly (3%). Although humans appear to have stopped accumulating r ...
... number of gene family members has expanded in humans, especially in proteins involved in development and immunity. The human genome has a much greater portion (50%) of repeat sequences than the mustard weed (11%), the worm (7%), and the fly (3%). Although humans appear to have stopped accumulating r ...
Supplementary Glossary 1
... proteins with diverse structure and function. The LRRs are typically 20-29 amino acids in length and contain a conserved consensus sequence of LxxLxLxxN/CxL (where x can be any amino acid and L can be replaced by V, I or F). There are several subgroups of LRR proteins, differentiated by the consensu ...
... proteins with diverse structure and function. The LRRs are typically 20-29 amino acids in length and contain a conserved consensus sequence of LxxLxLxxN/CxL (where x can be any amino acid and L can be replaced by V, I or F). There are several subgroups of LRR proteins, differentiated by the consensu ...
Genetics
... e.g. a person may have 4 repeats (CATCATCATCAT) and 6 repeats (CATCATCATCATCATCAT) on his homologous pair of number-7 chromosomes o These variable regions are inherited as codominant multiple alleles. Monozygous identical twins have the exact same DNA o Include VNTRs and STRs How DNA fingerprinting ...
... e.g. a person may have 4 repeats (CATCATCATCAT) and 6 repeats (CATCATCATCATCATCAT) on his homologous pair of number-7 chromosomes o These variable regions are inherited as codominant multiple alleles. Monozygous identical twins have the exact same DNA o Include VNTRs and STRs How DNA fingerprinting ...
lec9
... • GoStats sets a cutoff to obtain a subset of genes first (usually declared to be significantly different across conditions) conditions), and test if a GO term is over-represented in the subset • Another angle to consider the problem is to start with predefined gene sets instead of data-determined ...
... • GoStats sets a cutoff to obtain a subset of genes first (usually declared to be significantly different across conditions) conditions), and test if a GO term is over-represented in the subset • Another angle to consider the problem is to start with predefined gene sets instead of data-determined ...
Document
... • With positive control, a regulatory protein is an activator: it binds to DNA and stimulates transcription. • Positive inducible operon: transcription is normally turned off because the regulator protein (an activator) is produced in an active form. • Positive repressible operon: transcription norm ...
... • With positive control, a regulatory protein is an activator: it binds to DNA and stimulates transcription. • Positive inducible operon: transcription is normally turned off because the regulator protein (an activator) is produced in an active form. • Positive repressible operon: transcription norm ...
Hox Genes Notes unit 9 addendum
... complicated organisms like flies. Some “control” genes are common to many organisms (they are homologous—inherited from our common ancestor). For example, Hox genes help lay out the basic body forms of many animals, including humans, flies, and worms. They set up the head-to-tail organization. You c ...
... complicated organisms like flies. Some “control” genes are common to many organisms (they are homologous—inherited from our common ancestor). For example, Hox genes help lay out the basic body forms of many animals, including humans, flies, and worms. They set up the head-to-tail organization. You c ...
Transposable element
A transposable element (TE or transposon) is a DNA sequence that can change its position within the genome, sometimes creating or reversing mutations and altering the cell's genome size. Transposition often results in duplication of the TE. Barbara McClintock's discovery of these jumping genes earned her a Nobel prize in 1983.TEs make up a large fraction of the C-value of eukaryotic cells. There are at least two classes of TEs: class I TEs generally function via reverse transcription, while class II TEs encode the protein transposase, which they require for insertion and excision, and some of these TEs also encode other proteins. It has been shown that TEs are important in genome function and evolution. In Oxytricha, which has a unique genetic system, they play a critical role in development. They are also very useful to researchers as a means to alter DNA inside a living organism.