Sex-linked dosage-sensitive modifiers as imprinting
... Many modifiers of variegating position-effects (Locke et al. 1988), as well as modifiers of other phenotypes in Drosophila (Rabinow and Birchler, 1989), are responsive to gene dosage. Locke et al. (1988) have described a number of modifying genes that affect white-mottled and yellow variegation. The ...
... Many modifiers of variegating position-effects (Locke et al. 1988), as well as modifiers of other phenotypes in Drosophila (Rabinow and Birchler, 1989), are responsive to gene dosage. Locke et al. (1988) have described a number of modifying genes that affect white-mottled and yellow variegation. The ...
Evolutionary Origin of Recombination during Meiosis
... bacterial cell, whereby nonsister homologous chromosomes (or parts of chromosomes) originating from different parent cells align and undergo genetic recombination. The recombined DNA is passed on to a progeny bacterium. The core genes for meiosis were very likely present in the common ancestor of al ...
... bacterial cell, whereby nonsister homologous chromosomes (or parts of chromosomes) originating from different parent cells align and undergo genetic recombination. The recombined DNA is passed on to a progeny bacterium. The core genes for meiosis were very likely present in the common ancestor of al ...
Chromosome Variations
... a. Bill has 47 chromosomes. b. Betty has 47 chromosomes. c. Bill and Betty’s children have 47 chromosomes. d. Bill’s sister has 45 chromosomes. e. Bill has 46 chromosomes. f. Betty has 45 chromosomes. g. Bill’s brother has 45 chromosomes. **9. In mammals, sex chromosome aneuploids are more common th ...
... a. Bill has 47 chromosomes. b. Betty has 47 chromosomes. c. Bill and Betty’s children have 47 chromosomes. d. Bill’s sister has 45 chromosomes. e. Bill has 46 chromosomes. f. Betty has 45 chromosomes. g. Bill’s brother has 45 chromosomes. **9. In mammals, sex chromosome aneuploids are more common th ...
Drug-specific Sites of Topoisomerase II DNA
... boundaries; Ref. 15). Moreover, topoisomerase II cleavage sites often colocalize with DNase I-hypersensitive regions (16—19),which raises the possibility that the enzyme may function to establish or maintain the local topology at hypersensitive regions. In all of these studies, the topoisomerase I ...
... boundaries; Ref. 15). Moreover, topoisomerase II cleavage sites often colocalize with DNase I-hypersensitive regions (16—19),which raises the possibility that the enzyme may function to establish or maintain the local topology at hypersensitive regions. In all of these studies, the topoisomerase I ...
and phylogenetic characterization of Shuni virus Genomic
... 25–27] (Fig. S1), is less well conserved within the Simbu serogroup. Based on alignment with these viruses and comparison to the data obtained by Yanase et al. [9], protease cleavage between Gn/NSm of SAE18/09 occurs after the conserved arginine (R) 308 residue (Fig. S1). The cleavage site between N ...
... 25–27] (Fig. S1), is less well conserved within the Simbu serogroup. Based on alignment with these viruses and comparison to the data obtained by Yanase et al. [9], protease cleavage between Gn/NSm of SAE18/09 occurs after the conserved arginine (R) 308 residue (Fig. S1). The cleavage site between N ...
CSE 181 Project guidelines
... with itself. This can have change its properties • Several types exist, classified by function • mRNA – this is what is usually being referred to when a Bioinformatician says “RNA”. This is used to carry a gene’s message out of the nucleus. • tRNA – transfers genetic information from mRNA to an amin ...
... with itself. This can have change its properties • Several types exist, classified by function • mRNA – this is what is usually being referred to when a Bioinformatician says “RNA”. This is used to carry a gene’s message out of the nucleus. • tRNA – transfers genetic information from mRNA to an amin ...
DNA Mutation and Repair
... DNA Mutation and Repair • What if repairs are not made before replication? • All of these damage scenarios have the potential to lead to mutation if not fixed • Some of them can prevent replication from occurring so mechanisms have evolved to allow replication in spite of the problems • Most of the ...
... DNA Mutation and Repair • What if repairs are not made before replication? • All of these damage scenarios have the potential to lead to mutation if not fixed • Some of them can prevent replication from occurring so mechanisms have evolved to allow replication in spite of the problems • Most of the ...
Expansion of the Pseudo-autosomal Region and Ongoing
... sex chromosomes, remains sparse (Bergero et al. 2007) because, until recently, very few genes on these chromosomes had been identified. Those that have been mapped and sequenced from the X and Y demonstrate the existence of at least two evolutionary strata (Bergero et al. 2007). Genic markers are pre ...
... sex chromosomes, remains sparse (Bergero et al. 2007) because, until recently, very few genes on these chromosomes had been identified. Those that have been mapped and sequenced from the X and Y demonstrate the existence of at least two evolutionary strata (Bergero et al. 2007). Genic markers are pre ...
Epigenetics in mood disorders
... response to antidepressant treatment and ECS in the hippocampus of rodents, a brain region implicated in depression [8, 36, 37]. In mice subjected to chronic social defeat stress, chronically administered imipramine produced a selective hyperacetylation of histone H3 at the BDNF III and BDFN IV prom ...
... response to antidepressant treatment and ECS in the hippocampus of rodents, a brain region implicated in depression [8, 36, 37]. In mice subjected to chronic social defeat stress, chronically administered imipramine produced a selective hyperacetylation of histone H3 at the BDNF III and BDFN IV prom ...
Package `matchBox`
... The calcHypPI uses qhyper quantile function to compute the proportions of common features between two ordered vectors for specified quantiles of the hypergeometric distribution. Such proportions are used to add probability intervals to CAT curves computed using ranks (see computeCat). The prob argum ...
... The calcHypPI uses qhyper quantile function to compute the proportions of common features between two ordered vectors for specified quantiles of the hypergeometric distribution. Such proportions are used to add probability intervals to CAT curves computed using ranks (see computeCat). The prob argum ...
Slides
... Site Specific Recombination and Transposition - short segments of homologous DNA called attachment (att) sites or insertional (IS) elements §Recombination can lead to insertions, deletions, inversions, and translocations §Integration of bacteriophage l DNA into E. coli chromosome requires homologous ...
... Site Specific Recombination and Transposition - short segments of homologous DNA called attachment (att) sites or insertional (IS) elements §Recombination can lead to insertions, deletions, inversions, and translocations §Integration of bacteriophage l DNA into E. coli chromosome requires homologous ...
pdf
... propagated by infection of other individuals. This may be a natural means for evolving new strains of viruses. One of the most striking examples is the acquisition and modification of a protooncogene, such as cellular c-src, by a retrovirus to generate a modified, transforming form of the gene, call ...
... propagated by infection of other individuals. This may be a natural means for evolving new strains of viruses. One of the most striking examples is the acquisition and modification of a protooncogene, such as cellular c-src, by a retrovirus to generate a modified, transforming form of the gene, call ...
Cytogenetics Cytogenetics
... "land-mark" bands, and bands numbered sequentially within each. Sub-bands are catered for by using a decimal system ...
... "land-mark" bands, and bands numbered sequentially within each. Sub-bands are catered for by using a decimal system ...
Supplemental File S9. Homologous Chromosomes
... chromosomes (i.e. regions that contain different genetic information) do NOT participate in crossing over. Synapsis and the formation of synaptonemal complexes between duplicated X and Y chromosomes contributes to the even distribution of chromosomes into gametes during meiosis in males. ...
... chromosomes (i.e. regions that contain different genetic information) do NOT participate in crossing over. Synapsis and the formation of synaptonemal complexes between duplicated X and Y chromosomes contributes to the even distribution of chromosomes into gametes during meiosis in males. ...
File
... chromosomes consist of 22 homologous pairs of autosomes (chromosomes that do not determine the sex of the organism ) and 2 Xchromosomes that are sex-determining . Normal male cells also contain 46 chromosomes; the 22 pairs of autosomes and two dissimilar chromosomes - an X-chromosome and a much smal ...
... chromosomes consist of 22 homologous pairs of autosomes (chromosomes that do not determine the sex of the organism ) and 2 Xchromosomes that are sex-determining . Normal male cells also contain 46 chromosomes; the 22 pairs of autosomes and two dissimilar chromosomes - an X-chromosome and a much smal ...
Document
... • Sturtevant predicted that the farther apart two genes are, the higher the probability that a crossover will occur between them and therefore the higher the recombination frequency • in other words the farther apart two genes are the more likely they will be unlinked or “broken up” by crossing over ...
... • Sturtevant predicted that the farther apart two genes are, the higher the probability that a crossover will occur between them and therefore the higher the recombination frequency • in other words the farther apart two genes are the more likely they will be unlinked or “broken up” by crossing over ...
Correlations Between Gene Expression and Gene Conservation in
... 2A; Table 2). Although pombe-specific genes make up ∼13% of the genome, they represent >23% of sexually induced genes (P < 10ⳮ21). Moreover, pombe-specific genes were underrepresented among genes repressed during sexual differentiation, contributing only 5.9% of those genes (P < 10ⳮ7). We defined “p ...
... 2A; Table 2). Although pombe-specific genes make up ∼13% of the genome, they represent >23% of sexually induced genes (P < 10ⳮ21). Moreover, pombe-specific genes were underrepresented among genes repressed during sexual differentiation, contributing only 5.9% of those genes (P < 10ⳮ7). We defined “p ...
Detecting a Transposon in Corn
... that had intrigued botanists for centuries. (See Concept 32 of DNA From the Beginning, www.dnaftb.org, for an animation explaining McClintock’s elucidation of the Ac/Ds system.) Today the Ac/Ds system is an important tool in gene discovery, allowing scientists to characterize genes for which no biol ...
... that had intrigued botanists for centuries. (See Concept 32 of DNA From the Beginning, www.dnaftb.org, for an animation explaining McClintock’s elucidation of the Ac/Ds system.) Today the Ac/Ds system is an important tool in gene discovery, allowing scientists to characterize genes for which no biol ...
Genomic rearrangements in MSH2, MLH1 or MSH6 are rare in
... germline mutations in the mismatch repair (MMR) genes MLH1, MSH2, MSH6, PMS2 and MLH3. Most reported pathogenic mutations are point mutations, comprising single base substitutions, small insertions and deletions. In addition, genomic rearrangements, such as large deletions and duplications not detec ...
... germline mutations in the mismatch repair (MMR) genes MLH1, MSH2, MSH6, PMS2 and MLH3. Most reported pathogenic mutations are point mutations, comprising single base substitutions, small insertions and deletions. In addition, genomic rearrangements, such as large deletions and duplications not detec ...
Submitting an RNA-Seq job at PATRIC
... 4. Transcripts.txt file. This text file contains the data on a per gene bases. This data includes the contig, the transcription and translation stop and end sites, the strand, PATRIC and RefSeq locus tags, the functional description, estimates of abundance levels per gene, and the q-value. Est ...
... 4. Transcripts.txt file. This text file contains the data on a per gene bases. This data includes the contig, the transcription and translation stop and end sites, the strand, PATRIC and RefSeq locus tags, the functional description, estimates of abundance levels per gene, and the q-value. Est ...
Chapter 11 - Chromosome Mutations
... ploidy: number of chromosomes in an organism relative to a set of homologues euploidy: having a multiple of a complete set of homologues aneuploidy: having an incomplete set of homologues monoploid: a cell having only one chromosome set (usually an aberration), or an organism composed of such cells ...
... ploidy: number of chromosomes in an organism relative to a set of homologues euploidy: having a multiple of a complete set of homologues aneuploidy: having an incomplete set of homologues monoploid: a cell having only one chromosome set (usually an aberration), or an organism composed of such cells ...
Alu Background Information
... Alu elements are found only in primates – the "monkey" branch of the evolutionary tree, which includes humans. So, all of the hundreds of thousands of Alu copies have accumulated in primates since their separation from other vertebrate groups about 65 million years ago. Once an Alu integrates into a ...
... Alu elements are found only in primates – the "monkey" branch of the evolutionary tree, which includes humans. So, all of the hundreds of thousands of Alu copies have accumulated in primates since their separation from other vertebrate groups about 65 million years ago. Once an Alu integrates into a ...
A single splice site mutation in human
... this conclusion by determining the respective base at the homologous position in the ARHGAP11A genes of archaic hominins [Neanderthal and Denisova (29, 30), who carry both paralogs] and nonhuman primates (who carry only ARHGAP11A) (23–25). All ARHGAP11A genes analyzed, that is, those of archaic homi ...
... this conclusion by determining the respective base at the homologous position in the ARHGAP11A genes of archaic hominins [Neanderthal and Denisova (29, 30), who carry both paralogs] and nonhuman primates (who carry only ARHGAP11A) (23–25). All ARHGAP11A genes analyzed, that is, those of archaic homi ...
gmod-intro-07oct - IUBio Archive for Biology
... Getting Started w/ GMOD • gmod.org/Getting Started • Documentation is now rich and improving ...
... Getting Started w/ GMOD • gmod.org/Getting Started • Documentation is now rich and improving ...
Genomic library
A genomic library is a collection of the total genomic DNA from a single organism. The DNA is stored in a population of identical vectors, each containing a different insert of DNA. In order to construct a genomic library, the organism's DNA is extracted from cells and then digested with a restriction enzyme to cut the DNA into fragments of a specific size. The fragments are then inserted into the vector using DNA ligase. Next, the vector DNA can be taken up by a host organism - commonly a population of Escherichia coli or yeast - with each cell containing only one vector molecule. Using a host cell to carry the vector allows for easy amplification and retrieval of specific clones from the library for analysis.There are several kinds of vectors available with various insert capacities. Generally, libraries made from organisms with larger genomes require vectors featuring larger inserts, thereby fewer vector molecules are needed to make the library. Researchers can choose a vector also considering the ideal insert size to find a desired number of clones necessary for full genome coverage.Genomic libraries are commonly used for sequencing applications. They have played an important role in the whole genome sequencing of several organisms, including the human genome and several model organisms.