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Link to Powerpoint
Link to Powerpoint

... our understanding of gut bacteria • Culture-based studies over-emphasized the importance of easily culturable organisms (e.g. E. coli). Culture-independent surveys ...
Panel Topics
Panel Topics

...  How can expression (phenotype) and genotype information be integrated?  What kind of new information can be derived from the integration?  How can clinical information (treatment, survival, pathology) be utilized? ...
20.1 Structural Genomics Determines the DNA Sequences of Entire
20.1 Structural Genomics Determines the DNA Sequences of Entire

... DNA Sequences of Entire Genomes • Single-nucleotide polymorphisms: • A site in the genome where individual members of a species differ in a single base pair • Haplotype: the specific set of SNPs and other genetic variants observed on a chromosome • Linkage disequilibrium • Tag SNPs • Genome-wide ass ...
Using Gene Ontology - Center for Genomic Sciences
Using Gene Ontology - Center for Genomic Sciences

... for members of known function Problem: moderate changes in many genes simultaneously will escape detection New approach: start with a vocabulary of known GO categories or pathways, and look for coherent changes Variations: look for chromosome locations, or protein domains, that are common among many ...
Lecture
Lecture

...  1.045 billion bases sequenced  1800 microbial species estimated to exist in sample, ...
Determining the significance of a two
Determining the significance of a two

... Which genes are actually significant • There are 14 regulatory genes – which one is expressed under certain conditions? • Observe multiple genes of the bacteria under penicillin • Is the gene essential to the bacteria in the condition? • Use statistical approach ...
Bacteria Power Point File
Bacteria Power Point File

... surroundings, i.e., Avery’s experiment. B) Assimilated foreign DNA may be integrated into the bacterial chromosome by recombination C) Progeny of the recipient bacterium will carry a new combination of genes D) Many bacteria have surface proteins that recognize and import naked DNA from closely rela ...
The Human Genome, then begin Quantitative Genetics
The Human Genome, then begin Quantitative Genetics

... A. History of the genome effort B. Methods of sequencing the human genome 1. BAC to BAC: the hugo project. 2. All shotgun: the Celera project C. What we have learned from the human chromosome 1. Nucleotide makeup 2. Transposable elements 3. Nucleotide substitutions 4. The history of our genes 5. Dis ...
Wednesday, September 5
Wednesday, September 5

... programs that identify overlapping regions. ...
Discovery and analysis of inflammatory disease-related
Discovery and analysis of inflammatory disease-related

... Medical Center, Stanford, CA 94305; Synteni, Palo Alto, CA 94306; and § Department of Medicine, Manchester Royal Infirmary, Manchester, United Kingdom • Contributed by Ronald W. Davis, December 27, 1996 ...
Bacteria Notes File
Bacteria Notes File

Systematic Implications of DNA variation in subfamily
Systematic Implications of DNA variation in subfamily

... Should be present in all taxa to be compared Must have some knowledge of the gene or other genomic region to develop primers, etc. Evolutionary rate of sequence changes must be appropriate to the taxonomic level(s) being investigated; “slow” genes versus “fast” genes It is desirable that sequences c ...
Microbial Universe Part 3
Microbial Universe Part 3

This examination paper consists of 4 pages
This examination paper consists of 4 pages

... Can hold large pieces of chromosomal DNA Are rodent cell lines Are produced by irradiation with UV light Have been used in mapping the yeast genome ...
Understanding Domestication and Breeding by
Understanding Domestication and Breeding by

... Generally speaking, the path of sequencing to practice is like this:  Genome scale-At this stage we focus on the quality of the genomes, from draft to high quality to complete;  Population scale-we mine the variations in the populations, elucidate their features;  Panel scale-we prepare enough d ...
Microbial Taxonomy Traditional taxonomy or the classification
Microbial Taxonomy Traditional taxonomy or the classification

... to our perspective? ...
Biologic
Biologic

CV - B·Debate
CV - B·Debate

... Institute of Neurology, London, UK Prof John Hardy is a geneticist and molecular biologist whose research interests focus on neurological disease. Dr. Hardy received his B.Sc. (Hons) degree from the University of Leeds, UK (1976) and his Ph.D. from Imperial College, London, UK where he studied dopam ...
The Dinosaur Heresies
The Dinosaur Heresies

... Gene shuffling is likely still an important source of evolutionary novelty, especially in bacteria Modularity may not be the primary mode of innovation in protein sequences ...
the role of gene polymorphism in familiar cardiomyopathy
the role of gene polymorphism in familiar cardiomyopathy

... etiology. While the underlying cause of the disease is known to be partly genetic in nature, the contributory genes have not been fully deciphered yet. This study was designed to identify gene involved in familial (idiopathic) dDCM and HCM in the Saudi population as a study model. Accordingly, sever ...
Modern methods in biology
Modern methods in biology

... The race for the sequence: of patents and men Private companies join the race… And introduce new norms… ...
Dragonfly genome project
Dragonfly genome project

... Phylogeny: dragonfly among another insects Ancient and interesting, but not so well known insects ...
GeneticsLecture3
GeneticsLecture3

... 640Mb LINES, LINE-1 420Mb SINES, Alu million copies 250Mb LTR, ERV 200,000 copies 90Mb DNA transposons, PiggyBac 2000 copies ...
The UCSC Human Genome Browser
The UCSC Human Genome Browser

... for bacteria and protists, and even NIH funding for individual genome projects. NIAID separately funded the Anopheles gambiae genome at Celera, and TIGR (which later became the J. Craig Venter Institute or JCVI) has sequenced many others like the Asian tiger mosquito Aedes aegypti (vector of dengue ...
Biotechnology - Hicksville Public Schools / Homepage
Biotechnology - Hicksville Public Schools / Homepage

... In 1990, advances in DNA technology enabled scientists to completely sequence the human genome. A rough draft was complete in 2000. ...
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Pathogenomics

Pathogen infections are among the leading causes of infirmity and mortality among humans and other animals in the world. Until recently, it has been difficult to compile information to understand the generation of pathogen virulence factors as well as pathogen behaviour in a host environment. The study of Pathogenomics attempts to utilize genomic and metagenomics data gathered from high through-put technologies (e.g. sequencing or DNA microarrays), to understand microbe diversity and interaction as well as host-microbe interactions involved in disease states. The bulk of pathogenomics research concerns itself with pathogens that affect human health; however, studies also exist for plant and animal infecting microbes.
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