Honours core course - Comparative genomics (both lectures in 1 file)
... • Having genome sequences of many organisms allows large-scale comparisons, potentially automated • Can test hypotheses about genes whose rapid evolution may be related to special features of a particular species • In humans, this includes several genes with roles in brain development • The most uni ...
... • Having genome sequences of many organisms allows large-scale comparisons, potentially automated • Can test hypotheses about genes whose rapid evolution may be related to special features of a particular species • In humans, this includes several genes with roles in brain development • The most uni ...
Integrating the Bioinformatic Technology Group into your research
... reaction kinetics, binding, structural biology, statistical physics of soft matter ...
... reaction kinetics, binding, structural biology, statistical physics of soft matter ...
Control of Gene Express in Prokaryotes
... • Regulation of enzyme activityfeedback inhibition • Regulation of gene expression ...
... • Regulation of enzyme activityfeedback inhibition • Regulation of gene expression ...
Microarrays = Gene Chips
... • Each spot contains millions of copies of that single sequence – A bacterium’s entire genetic make-up can be contained on a single gene chip • A computer keeps track of which piece of DNA is contained in each spot ...
... • Each spot contains millions of copies of that single sequence – A bacterium’s entire genetic make-up can be contained on a single gene chip • A computer keeps track of which piece of DNA is contained in each spot ...
The Human Genome Project
... Parkinson’s disease—these are some of the most frightening names in pathology today and some of the most formidable foes that science must face on the battlegrounds of medicine. For years now, treatments have been developed, tested, and at best succeeded in slowing the progression of these ailments. ...
... Parkinson’s disease—these are some of the most frightening names in pathology today and some of the most formidable foes that science must face on the battlegrounds of medicine. For years now, treatments have been developed, tested, and at best succeeded in slowing the progression of these ailments. ...
105.1 Lastowska
... suggesting that this region includes a gene, or genes, critical for tumour pathogenesis. Because the shortest region of 17q gain (SRG) encompasses >300 genes, it precludes the identification of candidate genes from human breakpoint data alone. However, mouse chromosome 11, which is syntenic to human ...
... suggesting that this region includes a gene, or genes, critical for tumour pathogenesis. Because the shortest region of 17q gain (SRG) encompasses >300 genes, it precludes the identification of candidate genes from human breakpoint data alone. However, mouse chromosome 11, which is syntenic to human ...
What Have We Learned From Unicellular Genomes?
... “duplication events” at some point in time. Many regions of chromosomes are syntenic with regions on other chromosomes. Such paralogs are seen as evolutionary experiments where one gene can drift to provide new specialized functions. Some genes were initially thought to be extra copies but experimen ...
... “duplication events” at some point in time. Many regions of chromosomes are syntenic with regions on other chromosomes. Such paralogs are seen as evolutionary experiments where one gene can drift to provide new specialized functions. Some genes were initially thought to be extra copies but experimen ...
BB30055: Genes and genomes
... • Haplotype is a set of single nucleotide polymorphisms (SNPs) on a single chromatid that are statistically associated. • Haplotypes are generally shared between populations but their frequency can vary International HapMap Project (www.hapmap.org) – identifying common haplotypes in four populations ...
... • Haplotype is a set of single nucleotide polymorphisms (SNPs) on a single chromatid that are statistically associated. • Haplotypes are generally shared between populations but their frequency can vary International HapMap Project (www.hapmap.org) – identifying common haplotypes in four populations ...
Chromosomes and Sex
... 4. Why do “linked genes” NOT follow Mendel’s Law of Independent Assortment? ...
... 4. Why do “linked genes” NOT follow Mendel’s Law of Independent Assortment? ...
Exercise 1
... double stranded DNA molecule of length 2kb for complete digestion (any occurance will be cut). Assume the nucleotides are random with uniform probability (0.25 for each nucleotide). Consider the random variable X, which is the number of cleavage sites. Assuming that X is approximately Poisson distri ...
... double stranded DNA molecule of length 2kb for complete digestion (any occurance will be cut). Assume the nucleotides are random with uniform probability (0.25 for each nucleotide). Consider the random variable X, which is the number of cleavage sites. Assuming that X is approximately Poisson distri ...
gene families
... have been innumerable paracentric inversions within the arms, but very few pericentric inversions that would mix the arms, and relatively few translocations or transpositions between different chromosomes. The autosomal arms themselves have not even been reassociated with each other, e.g. 2L and 2R ...
... have been innumerable paracentric inversions within the arms, but very few pericentric inversions that would mix the arms, and relatively few translocations or transpositions between different chromosomes. The autosomal arms themselves have not even been reassociated with each other, e.g. 2L and 2R ...
Personal genomics as a major focus of CSAIL research
... Alzheimer’s-associated probes are hypermethylated ...
... Alzheimer’s-associated probes are hypermethylated ...
HGP102new
... number of gene family members has expanded in humans, especially in proteins involved in development and immunity. • The human genome has a much greater portion (50%) of repeat sequences than the mustard weed (11%), the worm (7%), and the fly (3%). ...
... number of gene family members has expanded in humans, especially in proteins involved in development and immunity. • The human genome has a much greater portion (50%) of repeat sequences than the mustard weed (11%), the worm (7%), and the fly (3%). ...
Chapter 21 Artificial Selection Artificial selection is the deliberate
... Artificial Selection Artificial selection is the deliberate selection by humans of organisms with characteristics useful to mankind. This selection has resulted in the evolution of a wide variety of crops and domesticated animals through selective breeding and hybridisation. ...
... Artificial Selection Artificial selection is the deliberate selection by humans of organisms with characteristics useful to mankind. This selection has resulted in the evolution of a wide variety of crops and domesticated animals through selective breeding and hybridisation. ...
Genetics of prokaryotic organisms
... Agrobacterium tumefaciens Escherichia coli Salmonella typhi Mycobacterium tuberculosis Bacillus megaterium ...
... Agrobacterium tumefaciens Escherichia coli Salmonella typhi Mycobacterium tuberculosis Bacillus megaterium ...
document
... between these 12 fly species, compared with vertebrates back to fish. The measure is essentially synonymous changes, which are presumably evolving close to neutral rates. The top line is pairwise comparisons, showing that comparisons across just the melanogaster species subgroup are half the distanc ...
... between these 12 fly species, compared with vertebrates back to fish. The measure is essentially synonymous changes, which are presumably evolving close to neutral rates. The top line is pairwise comparisons, showing that comparisons across just the melanogaster species subgroup are half the distanc ...
Introduction to Bioinformatics and Databases
... Too weakly conserved in other mammalian genomes, such as the mouse, to distinguish them from nonfunctional DNA Completely undetectable in nonmammalian genomes ...
... Too weakly conserved in other mammalian genomes, such as the mouse, to distinguish them from nonfunctional DNA Completely undetectable in nonmammalian genomes ...
Final Exam Review Sheet
... Southern, northern, and western blotting PCR methodology and applications (Reverse transcriptase-PCR, Real time-PCR) Automated and manual methods of DNA sequencing, including pyrosequencing Monoclonal antibody production and ELISAs DNA fingerprinting (especially VNTRs and STRs) Genetic engineering/e ...
... Southern, northern, and western blotting PCR methodology and applications (Reverse transcriptase-PCR, Real time-PCR) Automated and manual methods of DNA sequencing, including pyrosequencing Monoclonal antibody production and ELISAs DNA fingerprinting (especially VNTRs and STRs) Genetic engineering/e ...
Personal genomics as a major focus of CSAIL research
... Covers computational challenges associated with personal genomics: - genotype phasing and haplotype reconstruction resolve mom/dad chromosomes - exploiting linkage for variant imputation co-inheritance patterns in human population - ancestry painting for admixed genomes result of human migrat ...
... Covers computational challenges associated with personal genomics: - genotype phasing and haplotype reconstruction resolve mom/dad chromosomes - exploiting linkage for variant imputation co-inheritance patterns in human population - ancestry painting for admixed genomes result of human migrat ...
microarrays part1
... Try and find genes that are differentially expressed Study the function of these genes Find which genes interact with your favorite gene Extremely time consuming! ...
... Try and find genes that are differentially expressed Study the function of these genes Find which genes interact with your favorite gene Extremely time consuming! ...