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Genetics/Genomics Research
Genetics/Genomics Research

... Key features of successful mapping studies to causative base pairs • >1000 genotypes • Complete knowledge of DNA sequence • Replication in across environments • High quality measurement – Future: Daily measurement by robotics (may reduce some environmental ...
Functional Annotation of Animal Genomes (FAANG)
Functional Annotation of Animal Genomes (FAANG)

... • Chicken Genome Project (Washington University), NHGRI • Although there is no direct involvement with Swine Genome Project, NIH has always been interested in Swine as a model for growth, development, and disease since the pattern of growth and development of pigs is more similar to human. Several i ...
microarrays1
microarrays1

... Massively parallel analysis of gene expression • screen an entire genome at once • find not only individual genes that differ, but groups of genes that differ. • find relative expression level differences Shifting the interest from analysis of single molecules to large complexes and networks ...
Abstract
Abstract

... genetic risk scores can be calculated by integrating GWAS results with whole genome sequence data. On a broad scale, hereditary disease risks are similar for ancient hominins and modern-day humans. There is evidence that ancient pastoralists may have had healthier genomes than hunter-gatherers or fa ...
20070313_Questions
20070313_Questions

... browser? Would this be a useful way to search for diabetes related loci using this browser? Why or why not? 3) How many links were returned for the search term “diabetes” when searching the Ensembl human genome assembly? How many of these are genes? List their HUGO designation. 4) Which of the three ...
Phylogeny slides
Phylogeny slides

... Genome: set of chromosomes Chromosome: sequence of genes Genes: unique across entire genome Can simplify the representation of a genome by arbitrarily concatenating the ...
PCB 6528 Exam – Organelle genomes and gene expression
PCB 6528 Exam – Organelle genomes and gene expression

... bacterial genomes. Consequently, modern day plastid and plant mitochondrial genomes share some similar features and exhibit some interesting differences. Indicate whether each of the features below pertain to plastid genomes, plant mitochondrial genomes, both genomes or neither genome. Genome Featur ...
Whole genome sequencing and assembly of an avian genome, the
Whole genome sequencing and assembly of an avian genome, the

... sequenced fragments and makes use of this information to place the different fragments with respect to each other. This method of genome assembly is known as ‘shotgun’ genome sequencing. In this project we tested the benefits of an alternative method for genome assembly called reduced representation ...
2007.6. JW
2007.6. JW

... HERV-M (the human endogenous retrovirus M), related to the super family of HERV-K, has a Whole Genome sequence (Golden Path, hg16) ...
Building a better brain--Genomics conference unveils recent findings
Building a better brain--Genomics conference unveils recent findings

... Speakers in each scientific session described strategies for moving to large-scale genome-wide screens for genes. Scientists who traditionally have focused on a handful of genes now must grapple with the 30,000 to 40,000 genes present in the human genome and the even larger number of resulting prote ...
投影片 1
投影片 1

... research tools and technologies to rapidly and cost-effectively analyze genetic differences between people with specific illnesses, such as diabetes or heart disease, compared to healthy individuals. ...
Laureate 2016 Bios*Professor Peter Waterhouse
Laureate 2016 Bios*Professor Peter Waterhouse

... in crop plants is tantalizingly close but significant barriers must be overcome. Anticipated outcomes are safer, higher yielding and more sustainable crops. Australian Research Council funding: $2,715,383 About Professor Waterhouse Professor Peter Waterhouse is Professor of Molecular Genetics at Que ...
Laureate 2016 Bios—Professor Peter Waterhouse
Laureate 2016 Bios—Professor Peter Waterhouse

BIOTECHNOLOGY
BIOTECHNOLOGY

... Recombinant DNA Technology: Using the above tools, genes are combined from two or more different sources. The recombinant fragment is introduced into a cell that can express that gene. Uses:  Mass production of biochemicals needed by other species  Creation of new strains of living organisms  Pro ...
EVOLUTIONARY GENETICS (Genome 453) Practice problems for
EVOLUTIONARY GENETICS (Genome 453) Practice problems for

PPTX - Tandy Warnow
PPTX - Tandy Warnow

... epigenetics, microbiome Image courtesy of gurdanhealth.com ...
BB30055: Genes and genomes
BB30055: Genes and genomes

... Long Terminal Repeats (LTR) Repeats on the same orientation on both sides of element e.g. ATATATNNNNNNNATATAT • contain sequences that serve as transcription promoters • as well as terminators. • These sequences allow the element to code for an mRNA molecule that is processed and polyadenylated. • ...
Bacteria
Bacteria

... * No nucleus, chromosome is found in dense area, nucleoid * May also have xtra DNA in smaller circles, plasmids. * Division- DNA copies itself in both directions until entire circle has been replicated. - Then divides by binary fission. * Divide very quickly under good conditions. * E. coli divides ...
Crash course on Computational Biology for Computer Scientists
Crash course on Computational Biology for Computer Scientists

... We frequently sequence DNA originating from a genome closely related to a known one (e.g. human patient samples, bacteria, viruses, etc) Even though they are closely related, they are not identical (remember, mutations?) Sequence reads are short (30-100), genomes are long (up to 10^10) Obviously we ...
Document
Document

... Institute (EBI) and the Wellcome Trust Sanger Institute (WTSI) to develop a software system which produces and maintains automatic annotation on selected eukaryotic genomes. Ensembl is primarily funded by the Wellcome Trust. • Goals of Ensembl • The Ensembl project aims to provide: • Accurate, autom ...
Why the long neck?
Why the long neck?

... Species: Okapi johnstoni and Giraffa camelopardalis Genome size: 3.3 billion and 2.9 billion bases, respectively The genomes of the only two extant members of the Giraffidae family—the okapi (Okapi johnstoni) and the giraffe (subspecies Giraffa camelopardalis, tippelskirchi)—have been sequenced for ...
Zoo/Bot 3333
Zoo/Bot 3333

... 7. True or false: The only way that we can get zero recombinants is if an Hfr strain is crossed to an F + strain. 8. Which of the following can be classified as Hfr cells?. a) strains 5, 8, 2 and 4; b) strains 1, 2 and 4; c) strains 5 and 8; d) strains 1, 4 and 6; e) none of the above. Questions 9-1 ...
Genome Sequences of the Primary Endosymbiont “Candidatus
Genome Sequences of the Primary Endosymbiont “Candidatus

Chapter 8 Gene Transfer in Bacteria Conjugation Hfr Cells
Chapter 8 Gene Transfer in Bacteria Conjugation Hfr Cells

... genes are transferred together (cotransformed) • The rate of cotransformation is inversely proportional to the distances between genes. ...
Identification of func
Identification of func

... utilized to identify functionally important polymorphisms in “adaptive” genes that enable the individual to adapt to new environments. We propose that the drug response genes belong to this category of “adaptive” genes that leave behind these signatures which can be utilized to identify functional p ...
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Pathogenomics

Pathogen infections are among the leading causes of infirmity and mortality among humans and other animals in the world. Until recently, it has been difficult to compile information to understand the generation of pathogen virulence factors as well as pathogen behaviour in a host environment. The study of Pathogenomics attempts to utilize genomic and metagenomics data gathered from high through-put technologies (e.g. sequencing or DNA microarrays), to understand microbe diversity and interaction as well as host-microbe interactions involved in disease states. The bulk of pathogenomics research concerns itself with pathogens that affect human health; however, studies also exist for plant and animal infecting microbes.
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