The molecular epidemiology of iridovirus in Murray cod
... arbitrarily chosen as a limit. If both primers in the pair had E-values of less than 1.0 for the same non-target DNA, they were excluded. Candidate primers for discriminatory assays, C50/C51 and C82/C83, were tested against DNA from MCIV, DGIV-2004, RSIV and EHNV. Primers (M68/ M69 and M151/M152) kn ...
... arbitrarily chosen as a limit. If both primers in the pair had E-values of less than 1.0 for the same non-target DNA, they were excluded. Candidate primers for discriminatory assays, C50/C51 and C82/C83, were tested against DNA from MCIV, DGIV-2004, RSIV and EHNV. Primers (M68/ M69 and M151/M152) kn ...
1 Title: Long-term natural selection affects patterns of
... Interestingly, while divergence increases monotonically on the autosomes, this is not true for the X chromosome (Figure 1). We observe that divergence initially increases with increasing distance from genes, then observe a dip in divergence in the bin [0.10.2] cM from genes on the X chromosome (Figu ...
... Interestingly, while divergence increases monotonically on the autosomes, this is not true for the X chromosome (Figure 1). We observe that divergence initially increases with increasing distance from genes, then observe a dip in divergence in the bin [0.10.2] cM from genes on the X chromosome (Figu ...
et al - International Journal of Systematic and Evolutionary
... these proteins was previously available from only a limited number of actinobacteria, whose genomes have been sequenced. One possible signature for actinobacteria, consisting of a large insert in the 23S rRNA, has previously been described (Roller et al., 1992). However, the validity and specificity ...
... these proteins was previously available from only a limited number of actinobacteria, whose genomes have been sequenced. One possible signature for actinobacteria, consisting of a large insert in the 23S rRNA, has previously been described (Roller et al., 1992). However, the validity and specificity ...
1 X chromosome crossover formation and genome stability in
... The germ line efficiently combats numerous genotoxic insults to ensure the high fidelity propagation of unaltered genomic information across generations. Yet, germ cells in most metazoans also intentionally create double-strand breaks (DSBs) to promote DNA exchange between parental chromosomes, a pr ...
... The germ line efficiently combats numerous genotoxic insults to ensure the high fidelity propagation of unaltered genomic information across generations. Yet, germ cells in most metazoans also intentionally create double-strand breaks (DSBs) to promote DNA exchange between parental chromosomes, a pr ...
Nomenclature I
... while following the rules described previously, e.g., ACH for “achondroplasia.” It is usual for this symbol to change when the gene product or function is identified; however, if there is no additional information derived from the cloned gene, the disease symbol, e.g., ACH, will be maintained. If an ...
... while following the rules described previously, e.g., ACH for “achondroplasia.” It is usual for this symbol to change when the gene product or function is identified; however, if there is no additional information derived from the cloned gene, the disease symbol, e.g., ACH, will be maintained. If an ...
A Tree of Life Based on Protein Domain Organizations
... The number of the domain organizations extracted from each organism (nX) ranged between 266 and 4,762 among the 167 organisms, and 18,302 domain organizations were extracted from the organisms as a whole. As expected, nX was distinctively larger for eukaryotic organisms than for archaeal or bacteria ...
... The number of the domain organizations extracted from each organism (nX) ranged between 266 and 4,762 among the 167 organisms, and 18,302 domain organizations were extracted from the organisms as a whole. As expected, nX was distinctively larger for eukaryotic organisms than for archaeal or bacteria ...
PDF file
... Ab initio Gene Annotation Gene prediction carried out using AUGUSTUS • Arabidopsis as the gene prediction model • RNA-Seq data from ‘Jefferson’ (Data from Mockler lab) • Amino acid sequences of predicted genes were BLAST(P) searched for protein homology ...
... Ab initio Gene Annotation Gene prediction carried out using AUGUSTUS • Arabidopsis as the gene prediction model • RNA-Seq data from ‘Jefferson’ (Data from Mockler lab) • Amino acid sequences of predicted genes were BLAST(P) searched for protein homology ...
Divergence Pattern of Duplicate Genes in Protein
... duplicates follow a symmetric or nearly symmetric divergence pattern supports the random interaction turnover model. This model predicts symmetry in the divergence pattern of the duplicates under the assumption of an equal rate of new partner gains for two copies of one duplicate pair as well as a c ...
... duplicates follow a symmetric or nearly symmetric divergence pattern supports the random interaction turnover model. This model predicts symmetry in the divergence pattern of the duplicates under the assumption of an equal rate of new partner gains for two copies of one duplicate pair as well as a c ...
The Incompatible Desiderata of Gene Cluster Properties
... that is known is often based (somewhat circularly) on inferred homology of chromosomal segments. The properties underlying existing cluster definitions are generally not stated, and the dimensions along which they differ have been analyzed in only a cursory manner. As a result, the formal tradeoffs ...
... that is known is often based (somewhat circularly) on inferred homology of chromosomal segments. The properties underlying existing cluster definitions are generally not stated, and the dimensions along which they differ have been analyzed in only a cursory manner. As a result, the formal tradeoffs ...
Stretching DNA Fibers out of a Chromosome in Solution
... interphase nuclei for gene mapping. Their results show that the spatial resolution of FISH can approach 10kbp (kilo base pairs) when DNA is extended to a straight fiber. Therefore, physical manipulation of DNA is a useful technique for studying genomic DNA regions. In fact, manipulation of single DN ...
... interphase nuclei for gene mapping. Their results show that the spatial resolution of FISH can approach 10kbp (kilo base pairs) when DNA is extended to a straight fiber. Therefore, physical manipulation of DNA is a useful technique for studying genomic DNA regions. In fact, manipulation of single DN ...
Respect For Persons As A Guide To Genetic Enhancement
... The goal of the Human Genome Project, as stated by Dr. Louis Sullivan, is "to locate and describe the activity of human genes, to dispose for new treatments and cures for diseases, as well as to develop a deeper understanding of all biological processes." 1 But it follows that along with the illness ...
... The goal of the Human Genome Project, as stated by Dr. Louis Sullivan, is "to locate and describe the activity of human genes, to dispose for new treatments and cures for diseases, as well as to develop a deeper understanding of all biological processes." 1 But it follows that along with the illness ...
Experiment 2 Plasmid DNA Isolation, Restriction Digestion and Gel
... can be supercoiled. A single nick in one strand is sufficient to release the tension caused by all degrees of supercoiling. Even though all of these DNA forms have the same number of nucleotides and the same formula weight, they migrate differently during ...
... can be supercoiled. A single nick in one strand is sufficient to release the tension caused by all degrees of supercoiling. Even though all of these DNA forms have the same number of nucleotides and the same formula weight, they migrate differently during ...
Chapter 1: The Genetic Approach to Biology Questions for Chapter 1
... Idea of genes arose in early 1900s What key properties must hereditary material possess? 1. Ability to replicate faithfully (inheritance) 2. Provide an extraordinary diversity of information that can be 3. translated (changed) into structure and function of cells 4. Ability to change over time (evol ...
... Idea of genes arose in early 1900s What key properties must hereditary material possess? 1. Ability to replicate faithfully (inheritance) 2. Provide an extraordinary diversity of information that can be 3. translated (changed) into structure and function of cells 4. Ability to change over time (evol ...
primer on genetic epidemiology
... Fig. (3). Punnett squares of inherited traits. Punnett squares are used to predict the chance of genetic disease in children for parents with an increased risk. The disease-causing mutation is denoted by A and the normal gene is denoted by a. A) Autosomal dominant inheritance: A mother with an autos ...
... Fig. (3). Punnett squares of inherited traits. Punnett squares are used to predict the chance of genetic disease in children for parents with an increased risk. The disease-causing mutation is denoted by A and the normal gene is denoted by a. A) Autosomal dominant inheritance: A mother with an autos ...
A natural chimeric yeast containing genetic material from three species
... sequences of Saccharomyces sp. CID 1 and Saccharomyces sp. I F 0 1802 were identical. Also, the ATP9 sequences from S. pastorianus and S. bayanus were identical, while the sequences of other Saccharomyces species were different (Fig. 2). The data on the coding regions of the A TP8 and A TP9 genes su ...
... sequences of Saccharomyces sp. CID 1 and Saccharomyces sp. I F 0 1802 were identical. Also, the ATP9 sequences from S. pastorianus and S. bayanus were identical, while the sequences of other Saccharomyces species were different (Fig. 2). The data on the coding regions of the A TP8 and A TP9 genes su ...
Document
... 7.1 Chromosomes and Phenotype • Female mammals have an XX genotype. – Expression of sex-linked genes is similar to autosomal genes in females. – X chromosome inactivation randomly “turns off” one X chromosome – ensures that females, like males, have one functional copy of the X chromosome in each b ...
... 7.1 Chromosomes and Phenotype • Female mammals have an XX genotype. – Expression of sex-linked genes is similar to autosomal genes in females. – X chromosome inactivation randomly “turns off” one X chromosome – ensures that females, like males, have one functional copy of the X chromosome in each b ...
Trans - Wiley
... transesterification reactions 1. Attack by an external guanine on the 5′ splice site, adding the G to the 5′ end of the intron and releasing the first exon. 2. The first exon attacks the 3′ splice site, ligating the two exons together and releasing the linear intron. ...
... transesterification reactions 1. Attack by an external guanine on the 5′ splice site, adding the G to the 5′ end of the intron and releasing the first exon. 2. The first exon attacks the 3′ splice site, ligating the two exons together and releasing the linear intron. ...
(TSS) report - GEP Community Server
... From base to base Note: In some cases, the reconciled gene models (available under "Genes and Gene Prediction Tracks" this "Reconciled Gene GEP UCSC Genome Browser) might incorrect Complete report form for Models" each geneoninthe your project. Copy and paste this form tobe create as because of mis ...
... From base to base Note: In some cases, the reconciled gene models (available under "Genes and Gene Prediction Tracks" this "Reconciled Gene GEP UCSC Genome Browser) might incorrect Complete report form for Models" each geneoninthe your project. Copy and paste this form tobe create as because of mis ...
Section D - Prokaryotic and Eukaryotic Chromosome Structure
... Promoter: The sequence of DNA needed for RNA polymerase to bind to the template and accomplish the initiation reaction; the5’-side (upstream) of the coding region; the short conserved sequence (3) Unwind the DNA helix; For base pairing; Begins at the promoter site (4) Synthesis of the RNA strand at ...
... Promoter: The sequence of DNA needed for RNA polymerase to bind to the template and accomplish the initiation reaction; the5’-side (upstream) of the coding region; the short conserved sequence (3) Unwind the DNA helix; For base pairing; Begins at the promoter site (4) Synthesis of the RNA strand at ...
Evolutionary population genomics
... Two alternative processes can result in similar patterns of population differentiation The population structure in the Lake Constance region is consistent with ecological vicariance Adaptation has occurred only once; conclusions about the determinism of natural selection are flawed ...
... Two alternative processes can result in similar patterns of population differentiation The population structure in the Lake Constance region is consistent with ecological vicariance Adaptation has occurred only once; conclusions about the determinism of natural selection are flawed ...
Sorting Out the Genome
... could harbor the sequence d c b a e f g, with the first four genes inverted. A further reversal, affecting a different block of genes, could produce an ordering such as d c f e a b g. Theodosius Dobzhansky and Alfred H. Sturtevant, two of the leading Drosophilists, pointed out that such genetic rear ...
... could harbor the sequence d c b a e f g, with the first four genes inverted. A further reversal, affecting a different block of genes, could produce an ordering such as d c f e a b g. Theodosius Dobzhansky and Alfred H. Sturtevant, two of the leading Drosophilists, pointed out that such genetic rear ...
- California State University
... include at least one amino acid change between Denisovans and modern humans. The present study focuses primarily on single nucleotide changes (SNCs), loci at which the identity of the nucleotide at a particular locus is different between the modern human and Denisovan genomes. The SNCs being studied ...
... include at least one amino acid change between Denisovans and modern humans. The present study focuses primarily on single nucleotide changes (SNCs), loci at which the identity of the nucleotide at a particular locus is different between the modern human and Denisovan genomes. The SNCs being studied ...
Genetic Profiling of Changes Underlying Different Sized Human
... well as differences in healing and failure rates. By identifying modifiable targets related to failure, this important knowledge may help to guide treatment strategies and future research. It was hypothesized that massive human RC tendon tears will have different gene expression profiles when compar ...
... well as differences in healing and failure rates. By identifying modifiable targets related to failure, this important knowledge may help to guide treatment strategies and future research. It was hypothesized that massive human RC tendon tears will have different gene expression profiles when compar ...
Human genome
The human genome is the complete set of nucleic acid sequence for humans (Homo sapiens), encoded as DNA within the 23 chromosome pairs in cell nuclei and in a small DNA molecule found within individual mitochondria. Human genomes include both protein-coding DNA genes and noncoding DNA. Haploid human genomes, which are contained in germ cells (the egg and sperm gamete cells created in the meiosis phase of sexual reproduction before fertilization creates a zygote) consist of three billion DNA base pairs, while diploid genomes (found in somatic cells) have twice the DNA content. While there are significant differences among the genomes of human individuals (on the order of 0.1%), these are considerably smaller than the differences between humans and their closest living relatives, the chimpanzees (approximately 4%) and bonobos. Humans share 50% of their DNA with bananas.The Human Genome Project produced the first complete sequences of individual human genomes, with the first draft sequence and initial analysis being published on February 12, 2001. The human genome was the first of all vertebrates to be completely sequenced. As of 2012, thousands of human genomes have been completely sequenced, and many more have been mapped at lower levels of resolution. The resulting data are used worldwide in biomedical science, anthropology, forensics and other branches of science. There is a widely held expectation that genomic studies will lead to advances in the diagnosis and treatment of diseases, and to new insights in many fields of biology, including human evolution.Although the sequence of the human genome has been (almost) completely determined by DNA sequencing, it is not yet fully understood. Most (though probably not all) genes have been identified by a combination of high throughput experimental and bioinformatics approaches, yet much work still needs to be done to further elucidate the biological functions of their protein and RNA products. Recent results suggest that most of the vast quantities of noncoding DNA within the genome have associated biochemical activities, including regulation of gene expression, organization of chromosome architecture, and signals controlling epigenetic inheritance.There are an estimated 20,000-25,000 human protein-coding genes. The estimate of the number of human genes has been repeatedly revised down from initial predictions of 100,000 or more as genome sequence quality and gene finding methods have improved, and could continue to drop further. Protein-coding sequences account for only a very small fraction of the genome (approximately 1.5%), and the rest is associated with non-coding RNA molecules, regulatory DNA sequences, LINEs, SINEs, introns, and sequences for which as yet no function has been elucidated.