Investigating semantic similarity measures across the
... such processing. In this paper we investigate the use of ontological annotation to measure the similarities in knowledge content or “semantic similarity” between entries in a data resource. These allow a bioinformatician to perform a similarity measure over annotation in an analogous manner to those ...
... such processing. In this paper we investigate the use of ontological annotation to measure the similarities in knowledge content or “semantic similarity” between entries in a data resource. These allow a bioinformatician to perform a similarity measure over annotation in an analogous manner to those ...
video slide - SharpSchool
... Working with the mold Neurospora crassa, George Beadle and Edward Tatum had isolated mutants requiring arginine in their growth medium and had shown genetically that these mutants fell into three classes, each defective in a different gene. From other considerations, they suspected that the metaboli ...
... Working with the mold Neurospora crassa, George Beadle and Edward Tatum had isolated mutants requiring arginine in their growth medium and had shown genetically that these mutants fell into three classes, each defective in a different gene. From other considerations, they suspected that the metaboli ...
Gene Section SPP1 (secreted phosphoprotein 1) Atlas of Genetics and Cytogenetics
... The amino acid sequence of osteopontin is nowadays available for several species, such as rat, mouse, human, pig, rabbit and cow. The referenced mammalian osteopontin sequences are identical in ~33% of the residues, and in addition, many similar amino acids are conserved between the sequences. Ident ...
... The amino acid sequence of osteopontin is nowadays available for several species, such as rat, mouse, human, pig, rabbit and cow. The referenced mammalian osteopontin sequences are identical in ~33% of the residues, and in addition, many similar amino acids are conserved between the sequences. Ident ...
Chapter 2 - Water - Technicalsymposium
... Contain 80-100 detergent molecules. Used to trap grease and oils inside to remove them. 5) other noncovalent interactions in biomolecules There are four major noncovalent forces involved in the structure and function of biomolecules: 1) hydrogen bonds More important when they occur between and withi ...
... Contain 80-100 detergent molecules. Used to trap grease and oils inside to remove them. 5) other noncovalent interactions in biomolecules There are four major noncovalent forces involved in the structure and function of biomolecules: 1) hydrogen bonds More important when they occur between and withi ...
Lecture 3 Isoelectric Focusing
... Gradually increased through a series of steps to the desired focusing voltage Needs to be empirically determined, ...
... Gradually increased through a series of steps to the desired focusing voltage Needs to be empirically determined, ...
ProteoChem`s Current Catalogue.
... SPDP crosslinker is a cleavable, water insoluble, amino and thiol (sulfhydryl) reactive heterobifunctional protein crosslinker. The SPDP crosslinking reagent's reactive moites consist of an Nhydroxysuccinimide (NHS) ester that reacts with primary amines. On the other end of SPDP, the pyridinyldisulf ...
... SPDP crosslinker is a cleavable, water insoluble, amino and thiol (sulfhydryl) reactive heterobifunctional protein crosslinker. The SPDP crosslinking reagent's reactive moites consist of an Nhydroxysuccinimide (NHS) ester that reacts with primary amines. On the other end of SPDP, the pyridinyldisulf ...
Chapter Three
... Penicillin inhibits a transpeptidase that is used in bacterial cell wall construction. ...
... Penicillin inhibits a transpeptidase that is used in bacterial cell wall construction. ...
Post-Translational Processing (7.1)
... this amino acid is incorporated into the protein was unclear in these days. Today it is well established that the incorporation of selenocysteine is co-translational. Interestingly, the base triplet encoding this amino acid is UGA, a codon that normally functions as a STOP signal in translation. Sin ...
... this amino acid is incorporated into the protein was unclear in these days. Today it is well established that the incorporation of selenocysteine is co-translational. Interestingly, the base triplet encoding this amino acid is UGA, a codon that normally functions as a STOP signal in translation. Sin ...
Identification of Novel Drug Leads for Receptors Implicated in
... The 3d structure of HTR2 receptor was modeled since the crystal structure of HTR2 receptor was not available in the PDB. Using BLAST search against PDB templates or homologous proteins related to HTR2 were selected. This best aligned template is taken for homology modeling studies by using modeler ( ...
... The 3d structure of HTR2 receptor was modeled since the crystal structure of HTR2 receptor was not available in the PDB. Using BLAST search against PDB templates or homologous proteins related to HTR2 were selected. This best aligned template is taken for homology modeling studies by using modeler ( ...
Bioinformatics Molecular Genetics
... Promoter: a DNA sequence that enables a gene to be transcribed. The promoter is recognized by RNA polymerase, which then initiates transcription. Promoters represent critical elements that can work in concert with other regulatory regions (enhancers, silencers, boundary elements/insulators) to direc ...
... Promoter: a DNA sequence that enables a gene to be transcribed. The promoter is recognized by RNA polymerase, which then initiates transcription. Promoters represent critical elements that can work in concert with other regulatory regions (enhancers, silencers, boundary elements/insulators) to direc ...
Document
... Multiple Sequence Alignment tools are used to compare the amino acid sequences of more than two proteins. The word-size is the length of the seed set of amino acids, which needs to match exactly to get extended in both directions. Window Length is the length of the residues on either side, till whic ...
... Multiple Sequence Alignment tools are used to compare the amino acid sequences of more than two proteins. The word-size is the length of the seed set of amino acids, which needs to match exactly to get extended in both directions. Window Length is the length of the residues on either side, till whic ...
03_Krivov
... 3. From the linear regression resolve coefficients and their covariance 4. Maximization of quadratic form is relatively simple, provided that we can resolve eigenvalues and eigenvectors 5. Hence, generate sample of quadratic forms, maximize each of them and aggregate ...
... 3. From the linear regression resolve coefficients and their covariance 4. Maximization of quadratic form is relatively simple, provided that we can resolve eigenvalues and eigenvectors 5. Hence, generate sample of quadratic forms, maximize each of them and aggregate ...
Protein kinase A
... Regulation of fructose-1,6-bisphosphate metabolism by protein kinase A (cyclic AMP-dependent protein kinase). Formation of fructose-1,6-bis phosphate is accelerated by the metabolite fructose2,6-bisphosphate, which stimulates phosphofructokinase and inhibits fructose-1,6-phosphatase. Protein kinase ...
... Regulation of fructose-1,6-bisphosphate metabolism by protein kinase A (cyclic AMP-dependent protein kinase). Formation of fructose-1,6-bis phosphate is accelerated by the metabolite fructose2,6-bisphosphate, which stimulates phosphofructokinase and inhibits fructose-1,6-phosphatase. Protein kinase ...
Human complement factor H: expression of an additional truncated
... might be explained by an alternative splicing process of one factor H transcript. Southern blots of human chromosomal DNA hybridized with H-19 and H-46 revealed multiple bands pointing to an approximate gene size of more than 50 kb. From these data we cannot exclude that the three mRNA species are d ...
... might be explained by an alternative splicing process of one factor H transcript. Southern blots of human chromosomal DNA hybridized with H-19 and H-46 revealed multiple bands pointing to an approximate gene size of more than 50 kb. From these data we cannot exclude that the three mRNA species are d ...
(EC 2.2.1.1) active in the Calvin cycle of spinach chloroplasts
... indicated that the 1.2 kb XhoI-EcoRI insert of plasmid pHHU58 (accession number H55032) putatively encodes a partial cDNA for Sorghum TKL. The Sorghum cDNA insert was then used as a heterologous probe to screen our spinach cDNA library constructed from light-grown seedling mRNA. Details of construct ...
... indicated that the 1.2 kb XhoI-EcoRI insert of plasmid pHHU58 (accession number H55032) putatively encodes a partial cDNA for Sorghum TKL. The Sorghum cDNA insert was then used as a heterologous probe to screen our spinach cDNA library constructed from light-grown seedling mRNA. Details of construct ...
1 a molecules and their intera molecules and their interaction
... (d) Greatly weakens hydrophobic interaction Histones have very high percentage of arginine and lysine (15-30%). For this class of proteins which of the following reagents would be suitable for peptide sequencing of that histone protein? (a) CNBr (b) Trypsin (c) N-Bromosuccinamide (d) Chymotrypsin Wh ...
... (d) Greatly weakens hydrophobic interaction Histones have very high percentage of arginine and lysine (15-30%). For this class of proteins which of the following reagents would be suitable for peptide sequencing of that histone protein? (a) CNBr (b) Trypsin (c) N-Bromosuccinamide (d) Chymotrypsin Wh ...
Prezentace aplikace PowerPoint
... Transport of thyroid hormones by blood • Thyroid hormones are hydrophobic compounds and therefore they used for its transport carrier protein • The main transporting protein is thyroxine binding globulin (TBG). Its affinity for T4 is 10 times higher than for T3 . The further proteins, binding thyr ...
... Transport of thyroid hormones by blood • Thyroid hormones are hydrophobic compounds and therefore they used for its transport carrier protein • The main transporting protein is thyroxine binding globulin (TBG). Its affinity for T4 is 10 times higher than for T3 . The further proteins, binding thyr ...
Mathematical expressions useful in the
... having a complete library. However, it should be noted that rarely is the frequency of each member of the library the same and, thus, the simplification of Eqs. (14)–(16) can rarely be made. Even in the case where the Eq. (16) is not mathematically justified, it is still a useful, quick lower estima ...
... having a complete library. However, it should be noted that rarely is the frequency of each member of the library the same and, thus, the simplification of Eqs. (14)–(16) can rarely be made. Even in the case where the Eq. (16) is not mathematically justified, it is still a useful, quick lower estima ...
as a PDF
... 1980; Hemmings and Cohen, 1983 ; Woodgett, 1991), but has been demonstrated subsequently to be a multisubstrate protein kinase existing most abundantly in the brain (Yang and Fong, 1985 ; Yu and Yang, 1993; for review, see Yang, 1991) . Protein kinase FA/GSK3a was identified further as a brain micro ...
... 1980; Hemmings and Cohen, 1983 ; Woodgett, 1991), but has been demonstrated subsequently to be a multisubstrate protein kinase existing most abundantly in the brain (Yang and Fong, 1985 ; Yu and Yang, 1993; for review, see Yang, 1991) . Protein kinase FA/GSK3a was identified further as a brain micro ...
B130_Immunohistochemical identification of PAPP-A in
... is notebly expressed in unstable atherosclerotic plaques. It was shown that dPAPP-A is produced by activated cells of the immune system in unstable plaques and is released into the extracellular matrix. Also it was suggested that dPAPP-A could be involved in weakening of the fibrous cap. However, th ...
... is notebly expressed in unstable atherosclerotic plaques. It was shown that dPAPP-A is produced by activated cells of the immune system in unstable plaques and is released into the extracellular matrix. Also it was suggested that dPAPP-A could be involved in weakening of the fibrous cap. However, th ...
amino acids
... yields without the bitter β-form byproduct. • may hydrolyze into its constituent amino acids under conditions of elevated temperature or high pH. At room temperature, it is most stable at pH 4.3, where its half-life is nearly 300 days. At pH 7, however, its half-life is only a few days ...
... yields without the bitter β-form byproduct. • may hydrolyze into its constituent amino acids under conditions of elevated temperature or high pH. At room temperature, it is most stable at pH 4.3, where its half-life is nearly 300 days. At pH 7, however, its half-life is only a few days ...
Two-hybrid screening
Two-hybrid screening (also known as yeast two-hybrid system or Y2H) is a molecular biology technique used to discover protein–protein interactions (PPIs) and protein–DNA interactions by testing for physical interactions (such as binding) between two proteins or a single protein and a DNA molecule, respectively.The premise behind the test is the activation of downstream reporter gene(s) by the binding of a transcription factor onto an upstream activating sequence (UAS). For two-hybrid screening, the transcription factor is split into two separate fragments, called the binding domain (BD) and activating domain (AD). The BD is the domain responsible for binding to the UAS and the AD is the domain responsible for the activation of transcription. The Y2H is thus a protein-fragment complementation assay.