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Amino_Acids_and_Protein_Background_Info_
Amino_Acids_and_Protein_Background_Info_

... All amino acids have a simple chemical backbone with an amine group (the nitrogen containing part) at one end. At the other end is the acid part. This backbone is the same for all amino acids. The difference between them depends on a distinctive structure, the chemical side chain, that is attached t ...
The Structure and Function of Macromolecules
The Structure and Function of Macromolecules

... Two Types of Nucleic Acids Polymers  DNA (Deoxyribonucleic acid) • double stranded • can self replicate • makes up genes which code for proteins is passed from one generation to another  RNA (Ribonucleic acid) • single stranded • functions in actual synthesis of proteins coded for by DNA • is mad ...
Mass spectrometry and the search for moonlighting proteins
Mass spectrometry and the search for moonlighting proteins

... quite dramatically during evolution, with the addition or subtraction of entire helices, loop regions, and pockets. Because those surface features are all potential sites for a novel protein/ protein interaction function to evolve, it is quite possible that the random accumulation of mutations on PG ...
Genetic Transformation computer exercise
Genetic Transformation computer exercise

... mutated (GeneB) genes; this is known as a DNA sequence alignment. An alignment uses an algorithm (a step-by-step procedure) to compare the order of nucleotide bases in the sequences and then lines them up so that the number of identical bases is maximized. The alignment program will point out those ...
Genes affecting starch biosynthesis exert pleiotropic effects on the
Genes affecting starch biosynthesis exert pleiotropic effects on the

... Pea seeds, like those of other legumes, contain a relatively high proportion of total protein, but there are numerous methods to determine total protein. Traditionally, this has been determined by applying a conversion factor to the total nitrogen level of the seed or meal, and a factor of 6.25 has ...
BiochemReview
BiochemReview

... • Pol proceeds along DNA, making RNA 5’ to 3’. • In bacteria, RNA pol II is a holoenzyme. – It loses the s subunit when it binds DNA. – Without s, pol cannot find promoter. – The strand elongates, processively, like DNA pol III. ...
Jake Wang - Critical Review of the Rosetta Algorithm
Jake Wang - Critical Review of the Rosetta Algorithm

... independent of anything else that is built on top of it. Thus for the first scenario, S(i, j) = S(i+1, j-1) +1 since i and j can base pair. The same recursive methods apply for the other cases. In case 2, S(i,j) = S(i+1, j) + 0 since i is unpaired. Likewise, in case 3, S(i,j) = S(i, j-1) + 0 because ...
Proteins and Enzymes
Proteins and Enzymes

Hormones in intermediary metabolism
Hormones in intermediary metabolism

... • Mobilization of energy reserves and increase of energy expenditure (uncoupling proteins) • Increase of hepatic glycogenolysis and gluconeogenesis – α1 and β2 rec. (mild glycogenolysis in muscle – β2 rec., main activator is influx of Ca2+) decrease of glycolysis in liver ...
3.1-Carbohydrates and Lipids
3.1-Carbohydrates and Lipids

...  CHOLESTEROL: starting material for various hormones and is an important part of animal cell membranes ...
Practice Exam - mvhs
Practice Exam - mvhs

... phosphotriesterase so that it is able to catalyze the reaction even faster. To do this, they change a single amino acid that is part of the active site from a nonpolar amino acid to a positively charged amino acid. Use what you know about protein structure to explain how changing this amino acid cou ...
Title goes here - Center for Biological Sequence Analysis
Title goes here - Center for Biological Sequence Analysis

... What is a Project • Purpose ...
Complementing IHC with real-time interaction analysis on tissue
Complementing IHC with real-time interaction analysis on tissue

... • The way (how fast, how strong) an antibody binds potentially reveals  more than”how much” • Complement  IHC analysis          ...
protein research
protein research

... Molecular chaperones are extensively-studied proteins involved in the in vivo protein folding process. E. coli BL21 is an E. coli strain derived from E. coli B which possesses defects in the lon and ompT Outer membrane proteases. E. coli BL21 is commonly used for recombinant protein expression becau ...
Recognition Specificity for the Bacterial Avirulence Protein AvrPto Is
Recognition Specificity for the Bacterial Avirulence Protein AvrPto Is

... Agrobacterium tumefaciens can be used to transiently express AvrPto in plant cells (Scofield et al., 1996; Tang et al., 1996). We refined this assay by using a binary plasmid vector (pBTEX) that permits simultaneous expression of both avrPto and Pto genes with each gene under the control of a separa ...
Chapter 5 - macromolecules
Chapter 5 - macromolecules

... • Nucleotide polymers are linked together to build a polynucleotide • Adjacent nucleotides are joined by covalent bonds that form between the —OH group on the 3 carbon of one nucleotide and the phosphate on the 5 carbon on the next abc…lmnop • sugar-phosphate backbone (side of ladder) with nitroge ...
Protein prediction methods – steps of analysis
Protein prediction methods – steps of analysis

... Proteins can have a variety of functions and thus different cellular localisation. The proteins can be also classified upon their relationships to phospholipid bilayers i.e., those that are soluble and exist in the cytoplasm, in the lumen of an organelle or in the extracellular environments and thos ...
A novel approach for protein subcellular location prediction using
A novel approach for protein subcellular location prediction using

... the protein as a proxy for location based on the hypothesis that the physicochemical properties of the residues of a protein must be somehow coupled to the physicochemical properties of the environment where the protein performs its function; therefore the differences between environments will be im ...
PPARγ Regulated Fatty Acid Metabolism Antibody Sampler Kit
PPARγ Regulated Fatty Acid Metabolism Antibody Sampler Kit

bioinorganic 1
bioinorganic 1

... Hemoglobin’s active sites (all 4 of them) without the O2 is known as deoxyhemoglobin. The active site contains five-coordinate, pseudo-square planar Fe(+2). The fifth donor site is an imidazole ring from a histidine residue in the polypeptide chain. In deoxyhemoglobin the iron lies above the protopo ...
Summary Affimer reagents in affinity resins Specific target binding
Summary Affimer reagents in affinity resins Specific target binding

Milk Protein - AgroMedia International Inc
Milk Protein - AgroMedia International Inc

... energy for rumen microbes should be at least 35% of the ration dry matter. Levels above 40% of the ration dry matter may cause acidosis and digestibility of the entire diet may be reduced. In addition to energy, rumen microbes require a nitrogen source. This is provided by rumen degradable protein a ...
Biomolecule Review Worksheet
Biomolecule Review Worksheet

... even others form chains and rings. The sequence and shapes of the “R” groups control the shape and function of the protein. ...
Transcription Regulation Background: Lactose Background: How
Transcription Regulation Background: Lactose Background: How

... coliforms) have the ability to grow in media which contain lactose as their sole carbon source. Lactose is a sugar found in milk (a disaccharide). • To metabolise this sugar the bugs must produce two enzymes, beta galactosidase and lac permease. • If the E. coli are grown up on media with other carb ...
Macromolecule (biomolecule) Review Worksheet
Macromolecule (biomolecule) Review Worksheet

... are very small, others are large, and even others form chains and rings. The sequence and shapes of the “R” groups control the shape and function of the protein. 30. How many different amino acids are there? 31. What part of the amino acid varies from one amino acid to another? 32. What determines t ...
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Two-hybrid screening



Two-hybrid screening (also known as yeast two-hybrid system or Y2H) is a molecular biology technique used to discover protein–protein interactions (PPIs) and protein–DNA interactions by testing for physical interactions (such as binding) between two proteins or a single protein and a DNA molecule, respectively.The premise behind the test is the activation of downstream reporter gene(s) by the binding of a transcription factor onto an upstream activating sequence (UAS). For two-hybrid screening, the transcription factor is split into two separate fragments, called the binding domain (BD) and activating domain (AD). The BD is the domain responsible for binding to the UAS and the AD is the domain responsible for the activation of transcription. The Y2H is thus a protein-fragment complementation assay.
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