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Ms. Robyn Klemptner
Ms. Robyn Klemptner

... Elicitation of A.thaliana with ergosterol and total protein expression profiles. Enrich plant phosphopeptides using dendrimer technologies. Compare efficiencies of PAMAM vs. PolyMAC dendrimer enrichment techniques. Successful identification of differentially expressed phosphorylated proteins by Mass ...
Amino Acids
Amino Acids

... disulphide linkage. It is a covalent bond, but readily cleaved by reducing agents that supply the protons to form the SH groups again • Reducing agents include β-mercaptoethanol and DTT ...
Introduction to Protein Structure
Introduction to Protein Structure

... chemistry may need to be protected from the aqueous environment -for example, a charged molecule may be more attracted to water than to the second molecule involved in the biochemical reaction. In such a case, the charged molecule needs to be hidden away from the outside of the protein into a hydrop ...
Prokaryotic Cells, Eukaryotic cells and HIV: Structures, Transcription
Prokaryotic Cells, Eukaryotic cells and HIV: Structures, Transcription

... nascent polypeptide can go into the ER, even if the protein is not finished being made. Water soluble and transmembrane proteins can be made in the ER. However, once proteins go in the ER they typically do NOT go back out into the cytosol. They can be put in the plasma membrane or another compartmen ...
Peptides - Alfred State College
Peptides - Alfred State College

... Thermal stability ...
Skin Sensitivity Lab
Skin Sensitivity Lab

... Part A: Sensitivity – Applying different amounts of stimulus to different areas of the body – Is it felt or not? Part B: Discrimination – Applying stimulus to different areas of the body – What do you feel? ...
File - Thomas Tallis School
File - Thomas Tallis School

... The great number of jobs carried out by proteins means that they have to vary a lot in structure. Some proteins are insoluble strings, such as keratin and collagen. Others are soluble and round in shape such as enzymes and haemoglobin. The exact shapes of proteins can be very important in how they w ...
Mass Spectrometers - Porto Conte Ricerche
Mass Spectrometers - Porto Conte Ricerche

... MALDI (Matrix Assisted Laser Desorption Ionization) source provides accurate information on the structure and molecular weight of biomolecules such as peptides, proteins, oligonucleotides and carbohydrates, as well as synthetic polymers. Furthermore, through the PMF (Peptide MassFingerprinting) tech ...
1) (1) If Cedric wanted to purify a native protein that was fusing to a
1) (1) If Cedric wanted to purify a native protein that was fusing to a

... a) gel-filtration chromatography b) reversed-phase HPLC c) affinity chromatography d) anion-exchange chromatography e) cation-exchange chromatography 2) (1) In comparing the behavior of a 10,000 and 30,000 molecular weight protein using sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS- ...
Membranlar - mustafaaltinisik.org.uk
Membranlar - mustafaaltinisik.org.uk

... detergent treatment or with high salt ...
Progeria
Progeria

... This protein is what holds the cells nucleus together When this protein is defected it makes the nucleus unstable This is the process that leads to premature aging ...
The gene Q13L coding for the Capripoxvirus group specific
The gene Q13L coding for the Capripoxvirus group specific

... Escherichia coli using plasmid pGEX-2T as a fusion protein with glutathione-s-transferase and purified on glutathione sepharose affinity chromatography column. The protein was then employed for diagnosis of sheeppox, goatpox and lumpyskin disease, by a latex agglutination test (LAT) using the purifi ...
PROTEINS Dr Mervat Salah Dept of Nutrition
PROTEINS Dr Mervat Salah Dept of Nutrition

... (2) Net protein, utilization (NPU) = Nitrogen retained by the body ...
Three Dimensional Protein Structures
Three Dimensional Protein Structures

... Glu) are normally located on the surface of the protein in contact with water. • Uncharged polar residues (Ser, Thr, Asn, Gln, and Tyr) are usually on the protein surface but also occur in the interior of the protein. ...
proteins and protein structure
proteins and protein structure

... Hemoglobin is comprised of four polypeptide subunits (each has tertiary structure). All four components carry a heme group that can bind to oxygen, and all four components must be present to form hemoglobin. The shape of the hemoglobin affects its ability to carry oxygen, and travel freely throughou ...
Supplementary Information (doc 34K)
Supplementary Information (doc 34K)

... Samples were lysed in 1ml 50mM Tris-HCL buffer (pH 7.0) (Oxoid) by sonication in ice bath. Cell lysis process were conducted by 10s of sonication with 10s rest for 15 times until the cell suspension was clear. Cell suspensions were then centrifuged at 16,000g for 25mins at 4 ºC. The supernatant (wit ...
The World of Chemistry Episode 24
The World of Chemistry Episode 24

Episode 24 - The Genetic Code
Episode 24 - The Genetic Code

PowerPoint 簡報
PowerPoint 簡報

... Likely structure of rhodopsin complexed with G protein transducin 11-cis-retinal ...
y-ion series=A, AA, LAA, SLAA
y-ion series=A, AA, LAA, SLAA

... • Alterations between cells, tissues, and embryos often are not associated with changes in RNA levels, i.e. you cannot answer everything by RNA-seq; protein stability, protein localization, changes in PTMs, etc. • Only approximately 10% of all RNAs with changes of 1.5X or greater between two samples ...
Slide 1
Slide 1

... containing alternating glycosylated and nonglycosylated proteins were electrophoresed through a 13% polyacrylamide gel. After separation, the gel was stained with SYPRO Ruby protein gel stain to detect all eight marker proteins (left). Subsequently, the gel was stained by the standard periodic acid– ...
Chapter 5 - SchoolRack
Chapter 5 - SchoolRack

...  20 types of AAs that make up 1000s of different proteins  AAs are linked together by peptide bonds ...
Chapter 5
Chapter 5

... – Information on mRNA codes for particular proteins – Each amino acid • 3 base pair codon • This is picked up by transfer RNA (tRNA) • tRNA then brings the AA to the developing protein chain ...
Datasheet - BosterBio
Datasheet - BosterBio

... recommended to anyone who may be using Boster’s antibodies to, 1) treat or stain live cells, or 2) perform any primary amine coupling reaction. All conjugated antibodies should be stored in light-protected vials or covered with a light protecting materials (i.e. aluminum foil). Conjugated antibodies ...
Chapter 34-4B: Second Messengers
Chapter 34-4B: Second Messengers

... Chapter 21B: Hormons and Receptors ...
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Western blot



The western blot (sometimes called the protein immunoblot) is a widely used analytical technique used to detect specific proteins in a sample of tissue homogenate or extract. It uses gel electrophoresis to separate native proteins by 3-D structure or denatured proteins by the length of the polypeptide. The proteins are then transferred to a membrane (typically nitrocellulose or PVDF), where they are stained with antibodies specific to the target protein. The gel electrophoresis step is included in western blot analysis to resolve the issue of the cross-reactivity of antibodies.There are many reagent companies that specialize in providing antibodies (both monoclonal and polyclonal antibodies) against tens of thousands of different proteins. Commercial antibodies can be expensive, although the unbound antibody can be reused between experiments. This method is used in the fields of molecular biology, immunogenetics and other molecular biology disciplines. A number of search engines, such as CiteAb, Antibodypedia, and SeekProducts, are available that can help researchers find suitable antibodies for use in western blotting.Other related techniques include dot blot analysis, immunohistochemistry and immunocytochemistry where antibodies are used to detect proteins in tissues and cells by immunostaining, and enzyme-linked immunosorbent assay (ELISA).The method originated in the laboratory of Harry Towbin at the Friedrich Miescher Institute. The name western blot was given to the technique by W. Neal Burnette and is a play on the name Southern blot, a technique for DNA detection developed earlier by Edwin Southern. Detection of RNA is termed northern blot and was developed by George Stark at Stanford.
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