Ma et al 2009 - HKUST Institutional Repository
... In zebrafish, the Blastula Period, which runs from the 128-cell stage to ~50% epiboly (i.e., ~2.25 – 5.25 hpf), has been described as a stage of “regional specification”, during which several key developmental events take place (Kane and Warga, 2004). Several imaging techniques have been used to vis ...
... In zebrafish, the Blastula Period, which runs from the 128-cell stage to ~50% epiboly (i.e., ~2.25 – 5.25 hpf), has been described as a stage of “regional specification”, during which several key developmental events take place (Kane and Warga, 2004). Several imaging techniques have been used to vis ...
Short- and long-range functions of Goosecoid in
... Secreted ventralizing factors of the BMP, Wnt and Nodal families function in gradients in the early embryo and organizer-derived molecules attenuate the activity of these factors (Niehrs, 2004). Ventrally expressed Wnt8 restricts the size of the zebrafish organizer in the late blastula/early gastrul ...
... Secreted ventralizing factors of the BMP, Wnt and Nodal families function in gradients in the early embryo and organizer-derived molecules attenuate the activity of these factors (Niehrs, 2004). Ventrally expressed Wnt8 restricts the size of the zebrafish organizer in the late blastula/early gastrul ...
Interactions of Annexins with the mu Subunits of the Clathrin
... effectively reduce annexin A2 levels in cells have confirmed the importance of annexin A2 in the localization of transferrin receptor-containing recycling endosomes (10) as well as in the apical transport of vesicles in polarized epithelial cells (11) and in the formation of multivesicular transport ...
... effectively reduce annexin A2 levels in cells have confirmed the importance of annexin A2 in the localization of transferrin receptor-containing recycling endosomes (10) as well as in the apical transport of vesicles in polarized epithelial cells (11) and in the formation of multivesicular transport ...
TFIIH Plays an Essential Role in RNA Polymerase I Transcription
... the rDNA template in the presence of TFIIH-deficient TIF-IB. When assayed in the presence of TIF-IBIIH, however, transcriptional activity of TFIIH-deficient Pol I compared to that of Pol IIIH, indicating that specific Pol I transcription requires the presence of TFIIH. As a second approach to compar ...
... the rDNA template in the presence of TFIIH-deficient TIF-IB. When assayed in the presence of TIF-IBIIH, however, transcriptional activity of TFIIH-deficient Pol I compared to that of Pol IIIH, indicating that specific Pol I transcription requires the presence of TFIIH. As a second approach to compar ...
Myocyte Enhancer Factor 2 Transcription Factors in Heart
... switch, by potently activating or repressing transcription through interaction with a variety of co-factors which serve as positive and negative regulators of transcription. The interaction of MEF2 with its co-factors is controlled by a multitude of signaling pathways that result in posttranslationa ...
... switch, by potently activating or repressing transcription through interaction with a variety of co-factors which serve as positive and negative regulators of transcription. The interaction of MEF2 with its co-factors is controlled by a multitude of signaling pathways that result in posttranslationa ...
SCL and associated proteins distinguish active from
... HS2 of the human -globin locus control region (LCR), although the spacing between them is slightly larger.39 SCL is expressed at both early and late stages of hematopoietic development and is essential for normal hematopoietic stem cell (HSC) formation and later for the full differentiation of eryt ...
... HS2 of the human -globin locus control region (LCR), although the spacing between them is slightly larger.39 SCL is expressed at both early and late stages of hematopoietic development and is essential for normal hematopoietic stem cell (HSC) formation and later for the full differentiation of eryt ...
View/Open - eDiss - Georg-August
... Conserved microbial signatures are perceived via plasma membrane localized pattern recognition receptors (PRRs). In Arabidopsis, perception of the fungal cell wall component chitin requires the LysM receptor-like kinase CERK1. CERK1 is post-translationally modified to release a soluble ectodomain de ...
... Conserved microbial signatures are perceived via plasma membrane localized pattern recognition receptors (PRRs). In Arabidopsis, perception of the fungal cell wall component chitin requires the LysM receptor-like kinase CERK1. CERK1 is post-translationally modified to release a soluble ectodomain de ...
Drosophila Xpd Regulates Cdk7 Localization, Mitotic Kinase
... transcription is not required for development and survival. Towards producing such embryos we constructed mothers that express xpd in the soma only. For this we first made transgenic flies that express Xpd under UAST control [21]. UAS (‘‘upstream activating sequence’’) is a transcriptional enhancer ...
... transcription is not required for development and survival. Towards producing such embryos we constructed mothers that express xpd in the soma only. For this we first made transgenic flies that express Xpd under UAST control [21]. UAS (‘‘upstream activating sequence’’) is a transcriptional enhancer ...
Barley Aleurone Cells Contain Two Types of
... storage vacuoles and a distinctly different kind of organelle, which we have called secondary vacuoles. Differential interference contrast (DIC) microscopy showed that these two types of vacuole occur in both GA- and ABA-treated aleurone protoplasts (Figure 1). In Figure 1, the plane of focus was se ...
... storage vacuoles and a distinctly different kind of organelle, which we have called secondary vacuoles. Differential interference contrast (DIC) microscopy showed that these two types of vacuole occur in both GA- and ABA-treated aleurone protoplasts (Figure 1). In Figure 1, the plane of focus was se ...
Rhomboid-7 and HtrA2/Omi act in a common pathway with the
... et al., 2006; Mandemakers et al., 2007). Our understanding of the molecular events in PD pathogenesis has been greatly advanced by the identification and analysis of PD-associated genes (Farrer, 2006). The identification of mutations in PTENinduced putative kinase (PINK1, which encodes a mitochondri ...
... et al., 2006; Mandemakers et al., 2007). Our understanding of the molecular events in PD pathogenesis has been greatly advanced by the identification and analysis of PD-associated genes (Farrer, 2006). The identification of mutations in PTENinduced putative kinase (PINK1, which encodes a mitochondri ...
PDF - Multinational Arabidopsis Steering Committee
... should stand next to your poster, find your abstract in this book and note the new abstract number. The new number is your poster number, NOT the number it was assigned when you originally submitted. Posters are sequenced by topic and presenter. See the poster list below to determine which group con ...
... should stand next to your poster, find your abstract in this book and note the new abstract number. The new number is your poster number, NOT the number it was assigned when you originally submitted. Posters are sequenced by topic and presenter. See the poster list below to determine which group con ...
Live Imaging of Drosophila Brain Neuroblasts Reveals a Role for
... Lis1 is required for nuclear migration in fungi, cell cycle progression in mammals, and the formation of a folded cerebral cortex in humans. Lis1 binds dynactin and the dynein motor complex, but the role of Lis1 in many dynein/dynactindependent processes is not clearly understood. Here we generate a ...
... Lis1 is required for nuclear migration in fungi, cell cycle progression in mammals, and the formation of a folded cerebral cortex in humans. Lis1 binds dynactin and the dynein motor complex, but the role of Lis1 in many dynein/dynactindependent processes is not clearly understood. Here we generate a ...
New insights into regulation of p53 protein degradation
... Mdm2 activity and ubiquitination-dependent pathway [38, 40]. Further study suggested that NQO1 associates with the 20S proteasome, and that it prevents the degradation of proteins with unstructured regions, such as p53, p73 [33, 41], leads to stabilization of p53 and cellular protection [36]. Protei ...
... Mdm2 activity and ubiquitination-dependent pathway [38, 40]. Further study suggested that NQO1 associates with the 20S proteasome, and that it prevents the degradation of proteins with unstructured regions, such as p53, p73 [33, 41], leads to stabilization of p53 and cellular protection [36]. Protei ...
The G-protein regulator LGN modulates the activity of the NO
... plasmids revealed that they represent 26 proteins for the α1 screen and seven proteins for the β1 screen. One identified target, LGN, was present twice in the α1 screen and four times in the β1 screens. The specificity of interaction was then confirmed by transfecting the plasmid carrying the fusion ...
... plasmids revealed that they represent 26 proteins for the α1 screen and seven proteins for the β1 screen. One identified target, LGN, was present twice in the α1 screen and four times in the β1 screens. The specificity of interaction was then confirmed by transfecting the plasmid carrying the fusion ...
Abscisic Acid Coordinates Nod Factor and Cytokinin Signaling
... are known to mediate cell cycle arrest in pericycle cells (Li et al., 2006), thus inhibiting lateral root initiation (Laplaze et al., 2007). An analogous function has been found in Medicago truncatula (Gonzalez-Rizzo et al., 2006), and this indicates that changes in cytokinins will alter the balance ...
... are known to mediate cell cycle arrest in pericycle cells (Li et al., 2006), thus inhibiting lateral root initiation (Laplaze et al., 2007). An analogous function has been found in Medicago truncatula (Gonzalez-Rizzo et al., 2006), and this indicates that changes in cytokinins will alter the balance ...
mexCD-oprJ aeruginosa
... chlorhexidine (CHX), which perturb the cell envelope. Induction of mexCD-oprJ by membrane-damaging agents requires the envelope stress sigma factor AlgU, an indication that MexCD-OprJ is a component of the envelope stress response in P. aeruginosa. In the absence of CHX-mediated envelope stress, the ...
... chlorhexidine (CHX), which perturb the cell envelope. Induction of mexCD-oprJ by membrane-damaging agents requires the envelope stress sigma factor AlgU, an indication that MexCD-OprJ is a component of the envelope stress response in P. aeruginosa. In the absence of CHX-mediated envelope stress, the ...
Mechanical motion promotes expression of Prg4
... the recessive nature of CACP (Rhee et al. 2005). Col2-driven overexpression of lubricin in the articular cartilage has recently been shown to protect this tissue from degradation following surgically induced joint destabilization (Ruan et al. 2013), suggesting that lubricin may somehow counter the s ...
... the recessive nature of CACP (Rhee et al. 2005). Col2-driven overexpression of lubricin in the articular cartilage has recently been shown to protect this tissue from degradation following surgically induced joint destabilization (Ruan et al. 2013), suggesting that lubricin may somehow counter the s ...
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... terminal end (Vorburger et al., 1989; Weber et al., 1989a; Hennekes and Nigg, 1994; Sinensky et al., 1994). This occurs after incorporation of lamin A into the lamina (Lehner et al., 1986). In addition, the permanent membrane binding of B-type lamins may also involve the action of specific lamin B r ...
... terminal end (Vorburger et al., 1989; Weber et al., 1989a; Hennekes and Nigg, 1994; Sinensky et al., 1994). This occurs after incorporation of lamin A into the lamina (Lehner et al., 1986). In addition, the permanent membrane binding of B-type lamins may also involve the action of specific lamin B r ...
Gibberellins: Regulators of Plant Height
... In the 1950s the second group of hormones, the gibberellins (GAs), was characterized. The gibberellins are a large group of related compounds (more than 125 are known) that, unlike the auxins, are defined by their chemical structure rather than by their biological activity. Gibberellins are most oft ...
... In the 1950s the second group of hormones, the gibberellins (GAs), was characterized. The gibberellins are a large group of related compounds (more than 125 are known) that, unlike the auxins, are defined by their chemical structure rather than by their biological activity. Gibberellins are most oft ...
The secreted cell signal Folded Gastrulation regulates glial
... midline. The cells appear flat and spread out. (B) Htl-GAL4::UAS-mCD8GFP, UAS-dsfogRNA (glial fog RNAi). The glial lattice is disrupted, with gaps appearing in glial rows (arrow). Glia appear smaller and rounder, and fingerlike projections are observed around their edges; the gap between rows at the ...
... midline. The cells appear flat and spread out. (B) Htl-GAL4::UAS-mCD8GFP, UAS-dsfogRNA (glial fog RNAi). The glial lattice is disrupted, with gaps appearing in glial rows (arrow). Glia appear smaller and rounder, and fingerlike projections are observed around their edges; the gap between rows at the ...
Post-Translational Modifications of the TAK1-TAB Complex
... where TAK1 phosphorylates its substrates such as the inhibitor of nuclear factor κB kinase β (IKKβ) MAP kinase kinases (MKKs) including MKK3, MKK4, MKK6, and MKK7. IKKβ is a component of the IKK complex consisting of IKKα, IKKβ, and IKKγ (also referred to as NF-κB essential modulator (NEMO)) that is ...
... where TAK1 phosphorylates its substrates such as the inhibitor of nuclear factor κB kinase β (IKKβ) MAP kinase kinases (MKKs) including MKK3, MKK4, MKK6, and MKK7. IKKβ is a component of the IKK complex consisting of IKKα, IKKβ, and IKKγ (also referred to as NF-κB essential modulator (NEMO)) that is ...
Matching catalytic activity to developmental function: Tolloid
... remain ill defined. Embryos mutant for tlr show no significant defects in dorsal patterning, although it has recently been demonstrated that the level of Sog protein present in the dorsal region of tlr tld double mutant embryos is higher than in tld single mutants (Srinivasan et al., 2002). This led ...
... remain ill defined. Embryos mutant for tlr show no significant defects in dorsal patterning, although it has recently been demonstrated that the level of Sog protein present in the dorsal region of tlr tld double mutant embryos is higher than in tld single mutants (Srinivasan et al., 2002). This led ...
estrogen receptor by cyclin D1 Ligand
... Cyclin D1 is induced in response to mitogenic stimulation of quiescent cells and acts as an activator of CDK4 and CDK6. These cyclin D1/CDK complexes are key regulators of progression through the G1 phase of the cell cycle and are involved in functional inactivation of the retinoblastoma family prot ...
... Cyclin D1 is induced in response to mitogenic stimulation of quiescent cells and acts as an activator of CDK4 and CDK6. These cyclin D1/CDK complexes are key regulators of progression through the G1 phase of the cell cycle and are involved in functional inactivation of the retinoblastoma family prot ...
The contribution of the Trp/Met/Phe residues to physical interactions
... domain to CBP C-terminus promotes acetylation of the p53 Cterminal lysine residues by CBP/p300. The acetylations of the lysine residues contribute to the p53 stabilization by disabling the lysines as the ubiquitylation targets. The acetylation of p53 also stimulates its sequence specific DNA-binding ...
... domain to CBP C-terminus promotes acetylation of the p53 Cterminal lysine residues by CBP/p300. The acetylations of the lysine residues contribute to the p53 stabilization by disabling the lysines as the ubiquitylation targets. The acetylation of p53 also stimulates its sequence specific DNA-binding ...
DEVELOPMENT AND DISEASE Tbx5 is required for forelimb bud
... the limb were expressed in the forelimb region. Limb bud formation involves the establishment of key signalling centres within the nascent bud. Classical embryological experiments in the chick have demonstrated the requirement of the AER for limb bud outgrowth. Members of the fibroblast growth facto ...
... the limb were expressed in the forelimb region. Limb bud formation involves the establishment of key signalling centres within the nascent bud. Classical embryological experiments in the chick have demonstrated the requirement of the AER for limb bud outgrowth. Members of the fibroblast growth facto ...
Hedgehog signaling pathway
The Hedgehog signaling pathway (or signalling pathway; see spelling differences) is a signaling pathway that transmits information to embryonic cells required for proper development. Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult. Diseases associated with the malfunction of this pathway include basal cell carcinoma.The Hedgehog signaling pathway is one of the key regulators of animal development and is present in all bilaterians. The pathway takes its name from its polypeptide ligand, an intercellular signaling molecule called Hedgehog (Hh) found in fruit flies of the genus Drosophila. Hh is one of Drosophila's segment polarity gene products, involved in establishing the basis of the fly body plan. The molecule remains important during later stages of embryogenesis and metamorphosis.Mammals have three Hedgehog homologues, DHH, IHH, and SHH, of which Sonic (SHH) is the best studied. The pathway is equally important during vertebrate embryonic development. In knockout mice lacking components of the pathway, the brain, skeleton, musculature, gastrointestinal tract and lungs fail to develop correctly. Recent studies point to the role of Hedgehog signaling in regulating adult stem cells involved in maintenance and regeneration of adult tissues. The pathway has also been implicated in the development of some cancers. Drugs that specifically target Hedgehog signaling to fight this disease are being actively developed by a number of pharmaceutical companies.