Quantitative Rationalization of Gemfibrozil Drug Interactions
... Modeling and simulations were performed using the population-based absorption, distribution, metabolism, and excretion (ADME) simulator Simcyp (version 13; Simcyp Ltd., Sheffield, United Kingdom). Each simulation was performed for 50 virtual populations of healthy subjects (5 trials 10 subjects). ...
... Modeling and simulations were performed using the population-based absorption, distribution, metabolism, and excretion (ADME) simulator Simcyp (version 13; Simcyp Ltd., Sheffield, United Kingdom). Each simulation was performed for 50 virtual populations of healthy subjects (5 trials 10 subjects). ...
Atorvastatin functional groups
... Adding Fluorine to Pharmaceutical Compounds How did something that is so rare in nature – fluorine – become so common in. Original Article. Intensive Lipid Lowering with Atorvastatin in Patients with Stable Coronary Disease. John C. LaRosa, M.D., Scott M. Grundy, M.D., Ph.D., David D. Learn about Li ...
... Adding Fluorine to Pharmaceutical Compounds How did something that is so rare in nature – fluorine – become so common in. Original Article. Intensive Lipid Lowering with Atorvastatin in Patients with Stable Coronary Disease. John C. LaRosa, M.D., Scott M. Grundy, M.D., Ph.D., David D. Learn about Li ...
Antiinfective Agents
... Symptoms include nausea, abdominal cramps, flushing, vomiting, and headache. The reaction can happen if the patient ingests any form of alcohol including foods, drinks, and mouth rinses containing alcohol. Some people have experienced the symptoms if they smell alcohol, apply it to their bodies (e.g ...
... Symptoms include nausea, abdominal cramps, flushing, vomiting, and headache. The reaction can happen if the patient ingests any form of alcohol including foods, drinks, and mouth rinses containing alcohol. Some people have experienced the symptoms if they smell alcohol, apply it to their bodies (e.g ...
Deglycyrrhizinated Licorice Root Extract
... Contains no artificial preservatives, colours or sweeteners and no dairy, soy, wheat, gluten or yeast. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place. Recommended Adult Dose: Chew 1 tablet per day 20 minutes before each meal or as directed by a he ...
... Contains no artificial preservatives, colours or sweeteners and no dairy, soy, wheat, gluten or yeast. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place. Recommended Adult Dose: Chew 1 tablet per day 20 minutes before each meal or as directed by a he ...
Interactions between endothelin-1 and the renin–angiotensin
... situations, for instance, in pregnancy-induced hypertension, a vasospastic and volume-reduced disorder where endothelial cell damage is suspected to play an important role. Compared to normal pregnancy, pregnancy-induced hypertension was found to be associated with a two-fold increase in plasma irET ...
... situations, for instance, in pregnancy-induced hypertension, a vasospastic and volume-reduced disorder where endothelial cell damage is suspected to play an important role. Compared to normal pregnancy, pregnancy-induced hypertension was found to be associated with a two-fold increase in plasma irET ...
DEVELOPMENT, CHARACTERIZATION AND EVALUATION OF SOLID DISPERSIONS OF
... 0.44ug/ml respectively. Artemether has rapid onset of action and is rapidly eliminated from the body. It is thus thought to provide rapid symptomatic relief by reducing the number of malarial parasites whereas Lumefantrine has a much longer action and is used to clear residual parasites [8]. In Apri ...
... 0.44ug/ml respectively. Artemether has rapid onset of action and is rapidly eliminated from the body. It is thus thought to provide rapid symptomatic relief by reducing the number of malarial parasites whereas Lumefantrine has a much longer action and is used to clear residual parasites [8]. In Apri ...
Clinical Use And Limitations Of Non-Invasive
... of the AV node. Recently, statistical model-based analysis, combining ventricular response and information on atrial activity derived from the surface ECG (Figure 1), was proposed for evaluating essential AV nodal characteristics in AF. The method estimates five parameters which characterize the AV ...
... of the AV node. Recently, statistical model-based analysis, combining ventricular response and information on atrial activity derived from the surface ECG (Figure 1), was proposed for evaluating essential AV nodal characteristics in AF. The method estimates five parameters which characterize the AV ...
www.ijpbs.com Rishikesh S Deshmukh*et al Int J Pharm Bio Sci
... use of these metallic compounds. The synthetic dyes were much brighter, cheaper, more uniform, more stable (in their reactions to high processing temperatures, acids, carbon dioxide, storage and light) and more potent (i.e., less could be used to gain the same effect) than anything seen before, and ...
... use of these metallic compounds. The synthetic dyes were much brighter, cheaper, more uniform, more stable (in their reactions to high processing temperatures, acids, carbon dioxide, storage and light) and more potent (i.e., less could be used to gain the same effect) than anything seen before, and ...
ACUTE OTITIS MEDIA AND PHARYNGITIS IN CHILDREN Antibiotic
... The resistance of S. pneumoniae to ß lactamics is not due to the production of ß lactamase, but to the selection of bacterial strains with mutations of the penicillin binding proteins.19 The addition of clavulanic acid therefore does not increase the probability of eradicating the pneumococcus In ca ...
... The resistance of S. pneumoniae to ß lactamics is not due to the production of ß lactamase, but to the selection of bacterial strains with mutations of the penicillin binding proteins.19 The addition of clavulanic acid therefore does not increase the probability of eradicating the pneumococcus In ca ...
Ligand-Bound GeneSwitch Causes Developmental Aberrations in
... In order to determine whether the induction of these developmental defects was a general property of GeneSwitch drivers, or a phenomenon specific to tubGS, we repeated the experiment using a second GeneSwitch driver, under the control of the daughterless promoter. In contrast to tubGS, daGS in comb ...
... In order to determine whether the induction of these developmental defects was a general property of GeneSwitch drivers, or a phenomenon specific to tubGS, we repeated the experiment using a second GeneSwitch driver, under the control of the daughterless promoter. In contrast to tubGS, daGS in comb ...
Prodrugs: A challenge for the drug development
... The basic aim of prodrug design is to mask undesirable drug properties, such as low solubility in water or lipid membranes, low target selectivity, chemical instability, undesirable taste, irritation or pain after local administration, presystemic metabolism and toxicity [54, 70, 74]. In general, th ...
... The basic aim of prodrug design is to mask undesirable drug properties, such as low solubility in water or lipid membranes, low target selectivity, chemical instability, undesirable taste, irritation or pain after local administration, presystemic metabolism and toxicity [54, 70, 74]. In general, th ...
"Marijuana - Not Just Blowing Smoke"
... chemicals with a similar makeup. The areas of the brain controlling pleasure, thinking, memory, the ability to focus, sensory and time perception, and coordinated movement have high concentrations of these receptors. Consequently, these functions are affected the most by marijuana. Marijuana exposes ...
... chemicals with a similar makeup. The areas of the brain controlling pleasure, thinking, memory, the ability to focus, sensory and time perception, and coordinated movement have high concentrations of these receptors. Consequently, these functions are affected the most by marijuana. Marijuana exposes ...
This copy is for personal use only
... Drug administration. The following AEDs were used in this study: LEV (UCB Pharma, Braine-l’Alleud, Belgium) and CLB (Sanofi-Aventis Deutschland GmbH, Frankfurtam-Main, Germany). The drugs were suspended in a 1% solution of Tween 80 (Sigma, St. Louis, MO, USA) in distilled water, and administered int ...
... Drug administration. The following AEDs were used in this study: LEV (UCB Pharma, Braine-l’Alleud, Belgium) and CLB (Sanofi-Aventis Deutschland GmbH, Frankfurtam-Main, Germany). The drugs were suspended in a 1% solution of Tween 80 (Sigma, St. Louis, MO, USA) in distilled water, and administered int ...
DRUG ABSORPTION BY SUBLINGUAL AND RECTAL ROUTES
... route is therefore a suitable alternative, but unfortu- 44% following rectal administration in supnately few studies have been conducted in this area. positories. For oxymorphone Beaver and Feise (1977) showed that rectal administration was as Pentazocine, ketobemidone, oxymorphone and mor- effectiv ...
... route is therefore a suitable alternative, but unfortu- 44% following rectal administration in supnately few studies have been conducted in this area. positories. For oxymorphone Beaver and Feise (1977) showed that rectal administration was as Pentazocine, ketobemidone, oxymorphone and mor- effectiv ...
A study with cumulative doses of formoterol and salbutamol in
... drug. The difference in effect between the dose levels (0-1, 1- 2, 2-3, 3 to final administration of 1 mg salbutamol) of each drug was tested by Wilcoxon's signed rank test. For comparison between the two treatments at each dose level, absolute values were applied to pulse rate, blood pressure and t ...
... drug. The difference in effect between the dose levels (0-1, 1- 2, 2-3, 3 to final administration of 1 mg salbutamol) of each drug was tested by Wilcoxon's signed rank test. For comparison between the two treatments at each dose level, absolute values were applied to pulse rate, blood pressure and t ...
Literaturecherche Sabal serrulata und BPH - I-gap
... An increasing number of preclinical data, epidemiological evidences and clinical trials point to a potential role of natural compounds like herbal extracts, carotenoids and specific metals in the prevention and/or treatment of different prostate conditions, like hyperplasia, inflammation, cancer. Th ...
... An increasing number of preclinical data, epidemiological evidences and clinical trials point to a potential role of natural compounds like herbal extracts, carotenoids and specific metals in the prevention and/or treatment of different prostate conditions, like hyperplasia, inflammation, cancer. Th ...
The Development of Context-specific Operant Sensitization to d
... If sensitization develops, then less of a drug is needed to produce the original effects of the drug. Tolerance has been shown to be one process involved in the development of drug addiction. Tolerance can result in more of a drug being needed to achieve the same initial effect. Tolerance can either ...
... If sensitization develops, then less of a drug is needed to produce the original effects of the drug. Tolerance has been shown to be one process involved in the development of drug addiction. Tolerance can result in more of a drug being needed to achieve the same initial effect. Tolerance can either ...
Water Soluble Polymers for Pharmaceutical Applications
... The conjugation of PEG with enzymes looks very promising in antitumoral therapy since several enzymes have proven to be active against various types of cancer by acting through different mechanisms. Enzymes that are able to reduce plasma levels of these tumor target amino acids (i.e., asparaginase, ...
... The conjugation of PEG with enzymes looks very promising in antitumoral therapy since several enzymes have proven to be active against various types of cancer by acting through different mechanisms. Enzymes that are able to reduce plasma levels of these tumor target amino acids (i.e., asparaginase, ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... with bronchial hyperreactivity. Bronchodilators relieve cough in such individual and improve the effectiveness of cough in clearing secretions by increasing surface velocity of air flow during the act of coughing. They should be used only when an element of bronchoconstriction is present and not rou ...
... with bronchial hyperreactivity. Bronchodilators relieve cough in such individual and improve the effectiveness of cough in clearing secretions by increasing surface velocity of air flow during the act of coughing. They should be used only when an element of bronchoconstriction is present and not rou ...
new insights into the role of environmental context in the expression
... the effects of the drug on the appetitive and consummatory phases of feeding [22,23]. The appetitive phase involves locating, approaching, and maintaining contact with food. This phase is important in the bottle condition, but not in the cannula condition. The consummatory phase, on the other hand, ...
... the effects of the drug on the appetitive and consummatory phases of feeding [22,23]. The appetitive phase involves locating, approaching, and maintaining contact with food. This phase is important in the bottle condition, but not in the cannula condition. The consummatory phase, on the other hand, ...
Cyclodextrins in peptide and protein delivery
... T. Irie, K. Uekama / Advanced Drug Delivery Reviews 36 (1999) 101 – 123 ...
... T. Irie, K. Uekama / Advanced Drug Delivery Reviews 36 (1999) 101 – 123 ...
Psychopharmacology
Psychopharmacology (from Greek ψῡχή, psȳkhē, ""breath, life, soul""; φάρμακον, pharmakon, ""drug""; and -λογία, -logia) is the scientific study of the effects drugs have on mood, sensation, thinking, and behavior. It is distinguished from neuropsychopharmacology, which emphasizes the correlation between drug-induced changes in the functioning of cells in the nervous system and changes in consciousness and behavior.The field of psychopharmacology studies a wide range of substances with various types of psychoactive properties, focusing primarily on the chemical interactions with the brain.Psychoactive drugs interact with particular target sites or receptors found in the nervous system to induce widespread changes in physiological or psychological functions. The specific interaction between drugs and their receptors is referred to as ""drug action"", and the widespread changes in physiological or psychological function is referred to as ""drug effect"". These drugs may originate from natural sources such as plants and animals, or from artificial sources such as chemical synthesis in the laboratory.