Short-Term Fasting Alters Cytochrome P450–Mediated Drug
... can be explained by the altered activity of nuclear transcription factors. The nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (Klein et al., 1993) serve as xenosensors, which regulate the activity of many of the drug-metabolizing P450 enzymes in animals (Hernandez e ...
... can be explained by the altered activity of nuclear transcription factors. The nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (Klein et al., 1993) serve as xenosensors, which regulate the activity of many of the drug-metabolizing P450 enzymes in animals (Hernandez e ...
Nota Técnica
... extract is regulated, as it is associated with diuretic responses and can affect the action of some drugs.6 CAF also influences central nervous system activity7 and is responsible for the harmful effects associated with green tea overconsumption. Higher doses of CAF (>200 mg day−1) can cause anxiety ...
... extract is regulated, as it is associated with diuretic responses and can affect the action of some drugs.6 CAF also influences central nervous system activity7 and is responsible for the harmful effects associated with green tea overconsumption. Higher doses of CAF (>200 mg day−1) can cause anxiety ...
clonazepam - Genentech
... attendant hypoxia and threat to life. In individual cases where the severity and frequency of the seizure disorder are such that the removal of medication does not pose a serious threat to the patient, discontinuation of the drug may be considered prior to and during pregnancy; however, it cannot be ...
... attendant hypoxia and threat to life. In individual cases where the severity and frequency of the seizure disorder are such that the removal of medication does not pose a serious threat to the patient, discontinuation of the drug may be considered prior to and during pregnancy; however, it cannot be ...
A Study of Abrupt Phentermine Cessation in Patients in
... a return of hunger, cravings, or both. After a variable time lag, such patients find it increasingly difficult to maintain control of their food intake and most of them gain weight. Some patients on long-term phentermine (more than 90 days) have discontinued phentermine repeatedly. Such patients, ha ...
... a return of hunger, cravings, or both. After a variable time lag, such patients find it increasingly difficult to maintain control of their food intake and most of them gain weight. Some patients on long-term phentermine (more than 90 days) have discontinued phentermine repeatedly. Such patients, ha ...
SEMINAR ON BUCCAL DRUG DELIVERY SYSTUM
... many pharmaceuticals and can be tailored to adhere to any mucosal tissue, The bioadhesive microspheres can be used not only for controlled release but also for targeted delivery of the drugs to specific sites in body. Recent advances , development of polymeric drug delivery systems for protein/pep ...
... many pharmaceuticals and can be tailored to adhere to any mucosal tissue, The bioadhesive microspheres can be used not only for controlled release but also for targeted delivery of the drugs to specific sites in body. Recent advances , development of polymeric drug delivery systems for protein/pep ...
contents - Médecins d`Afrique
... of Chemistry, Institute of Analytical Science, Southwest China Normal University, Beibei, Chongqing, 400715, China] - J. PHARM. BIOMED. ANAL. 2003 33/4 (765-773) - summ in ENGL The binding of terbutaline sulfate to bovine serum albumin was studied in vitro using the technique of microdialysis sampli ...
... of Chemistry, Institute of Analytical Science, Southwest China Normal University, Beibei, Chongqing, 400715, China] - J. PHARM. BIOMED. ANAL. 2003 33/4 (765-773) - summ in ENGL The binding of terbutaline sulfate to bovine serum albumin was studied in vitro using the technique of microdialysis sampli ...
Kwartaalbericht
... typical absence epilepsy. Furthermore it is indicated for bipolar disorder. For people of 18 years and older is it also indicated for prevention of depressive episodes in patients with a bipolar I disorder who mainly experience depressive episodes [1]. Lamotrigine is a voltage-dependent blocker of v ...
... typical absence epilepsy. Furthermore it is indicated for bipolar disorder. For people of 18 years and older is it also indicated for prevention of depressive episodes in patients with a bipolar I disorder who mainly experience depressive episodes [1]. Lamotrigine is a voltage-dependent blocker of v ...
Are placebos inert or powerful? Vice versa
... distributional effects. To study a treatment, patients are selected at one end of a distribution, for example blood pressure, cholesterol and depression. These commodities vary with time. When one looks at the distribution later, the distribution may look the same, but the positions of individuals w ...
... distributional effects. To study a treatment, patients are selected at one end of a distribution, for example blood pressure, cholesterol and depression. These commodities vary with time. When one looks at the distribution later, the distribution may look the same, but the positions of individuals w ...
Chapter-1 Introduction
... intravenous reference dose (absolute bioavailability study). The permeability class of a drug may also be determined using in-vivo intestinal perfusion approaches (human or appropriate animal models) or in-vitro permeation studies (excised human or animal intestinal tissues or monolayers of cultured ...
... intravenous reference dose (absolute bioavailability study). The permeability class of a drug may also be determined using in-vivo intestinal perfusion approaches (human or appropriate animal models) or in-vitro permeation studies (excised human or animal intestinal tissues or monolayers of cultured ...
Management of Cocaine-Associated Chest Pain and Myocardial Infarction : A
... MI but also by aortic dissection, and this must be considered in the differential diagnosis. Information concerning cocaineinduced aortic dissection is limited, but one study of 38 consecutive patients with aortic dissection in a US urban center demonstrated a surprisingly high number (14, 37%) that ...
... MI but also by aortic dissection, and this must be considered in the differential diagnosis. Information concerning cocaineinduced aortic dissection is limited, but one study of 38 consecutive patients with aortic dissection in a US urban center demonstrated a surprisingly high number (14, 37%) that ...
Anyanwu, Philip, Fulton, John, Paget, Timothy and Evans, Etta (2016
... countries, the high cost of antimalarial drugs - like the ACTs class of drugs - leads to drug use behaviours such as not using the recommended class of drugs [12], use of monotherapies, nonadherence to treatment regimen [13], presumptive and self-treatment [14-16] amongst others. In addition, other ...
... countries, the high cost of antimalarial drugs - like the ACTs class of drugs - leads to drug use behaviours such as not using the recommended class of drugs [12], use of monotherapies, nonadherence to treatment regimen [13], presumptive and self-treatment [14-16] amongst others. In addition, other ...
Reporting Drug Concentrations: Mass or Molar Units?
... units. Reports of patient harm due to misinterpretation of drug concentrations lead to establishment of the Working Party. Another issue increasingly relevant to uniformity of reporting units is the rise of health databases containing results from more than one laboratory. These databases may cover ...
... units. Reports of patient harm due to misinterpretation of drug concentrations lead to establishment of the Working Party. Another issue increasingly relevant to uniformity of reporting units is the rise of health databases containing results from more than one laboratory. These databases may cover ...
2015 insulin
... • Act by binding to SUR1 on beta cells to promote insulin secretion. • Repaglinide (瑞格列奈) and Nateglinide (那格列奈) are currently available agents. • Efficacy of repaglinide appears to be similar to SU’s • Major advantage is rapid onset and offset, can dose just ...
... • Act by binding to SUR1 on beta cells to promote insulin secretion. • Repaglinide (瑞格列奈) and Nateglinide (那格列奈) are currently available agents. • Efficacy of repaglinide appears to be similar to SU’s • Major advantage is rapid onset and offset, can dose just ...
- The University of Liverpool Repository
... As highlighted by Denning and Bromley (23), the antifungal pipeline has failed to produce new antifungal drugs with mechanisms of action different to existing classes since caspofungin was licensed in 2001. Many potential antifungal targets have been investigated but translating these early stage p ...
... As highlighted by Denning and Bromley (23), the antifungal pipeline has failed to produce new antifungal drugs with mechanisms of action different to existing classes since caspofungin was licensed in 2001. Many potential antifungal targets have been investigated but translating these early stage p ...
product monograph
... which these should be given can be determined only by the attending physician as dictated by the course of clinical events. The total dose of HEMABATE STERILE SOLUTION should not exceed 2 mg (8 doses). OVERDOSAGE Overdosage with HEMABATE STERILE SOLUTION (carboprost tromethamine) should result in th ...
... which these should be given can be determined only by the attending physician as dictated by the course of clinical events. The total dose of HEMABATE STERILE SOLUTION should not exceed 2 mg (8 doses). OVERDOSAGE Overdosage with HEMABATE STERILE SOLUTION (carboprost tromethamine) should result in th ...
Prodrugs—from Serendipity to Rational Design
... inhibits irreversibly cyclooxygenase, the enzyme responsible for formation of the key biological mediators, prostaglandins and thromboxanes, by acetylating one hydroxyl group of serine residue (Ser 530) in the active site of the enzyme, while the parent drug, salicylic acid, is a weak reversible inh ...
... inhibits irreversibly cyclooxygenase, the enzyme responsible for formation of the key biological mediators, prostaglandins and thromboxanes, by acetylating one hydroxyl group of serine residue (Ser 530) in the active site of the enzyme, while the parent drug, salicylic acid, is a weak reversible inh ...
Thin-layer agar for detection of resistance to rifampicin, ofloxacin
... low-cost method that can reduce the time to detection of resistance in M. tuberculosis to 10 days compared to several weeks using the conventional proportion method. Microcolonies could be seen under the microscope long before they were observed visually. Although the method is easy to perform, a mi ...
... low-cost method that can reduce the time to detection of resistance in M. tuberculosis to 10 days compared to several weeks using the conventional proportion method. Microcolonies could be seen under the microscope long before they were observed visually. Although the method is easy to perform, a mi ...
effects of cytochrome p450 enzyme inhibitors and inducers
... when one drug or herb affects the absorption, distribution, metabolism or excretion of another drug (Magro et al. 2012). These drug-drug interactions (DDIs) occur during drug metabolism. Cytochrome P450 (CYP) enzymes, in the liver and intestine, play a major role in the metabolism of drugs and other ...
... when one drug or herb affects the absorption, distribution, metabolism or excretion of another drug (Magro et al. 2012). These drug-drug interactions (DDIs) occur during drug metabolism. Cytochrome P450 (CYP) enzymes, in the liver and intestine, play a major role in the metabolism of drugs and other ...
EA_QA312.3_levothyroxineseakelp
... as 1 mg of iodine (5). In addition the iodine content of kelp products can vary considerably, even within products of the same brand (1, 4). When progressively larger doses of iodine are ingested there is an initial rise in thyroid hormone production, but as doses continue to rise production is redu ...
... as 1 mg of iodine (5). In addition the iodine content of kelp products can vary considerably, even within products of the same brand (1, 4). When progressively larger doses of iodine are ingested there is an initial rise in thyroid hormone production, but as doses continue to rise production is redu ...
GLYTRIN SPRAY
... enhances the hypotensive effect. Therefore, the concomitant administration of GLYTRIN Spray and medicines for male erectile dysfunction is contraindicated. If a patient treated with medicines for male erectile dysfunction needs a rapidly effective nitrate (e.g. in the case of an acute angina pectori ...
... enhances the hypotensive effect. Therefore, the concomitant administration of GLYTRIN Spray and medicines for male erectile dysfunction is contraindicated. If a patient treated with medicines for male erectile dysfunction needs a rapidly effective nitrate (e.g. in the case of an acute angina pectori ...
Interventional Role of Piperazine Citrate in Barium Chloride Induced
... Beta-blocking agent such as propranolol negates this buffering effect [47], and contributes to its anti-arrhythmic action. Similarly, piperazine may negate the arrhythmogenic effect of BaCl2 by blocking the K+ channels. Since most K+ channel blocking drugs also interact with beta-adrenergic receptor ...
... Beta-blocking agent such as propranolol negates this buffering effect [47], and contributes to its anti-arrhythmic action. Similarly, piperazine may negate the arrhythmogenic effect of BaCl2 by blocking the K+ channels. Since most K+ channel blocking drugs also interact with beta-adrenergic receptor ...
A Rare Adverse Effect of Montelukast Treatment
... beginning leukotriene receptor antagonists in asthmatic patients not treated with steroids.22 The American College of Rheumatology23 has proposed 6 criteria for the diagnosis of Churg-Strauss syndrome: asthma (wheezing, expiratory rhonchi), eosinophilia of ⬎ 10% in peripheral blood, paranasal sinusi ...
... beginning leukotriene receptor antagonists in asthmatic patients not treated with steroids.22 The American College of Rheumatology23 has proposed 6 criteria for the diagnosis of Churg-Strauss syndrome: asthma (wheezing, expiratory rhonchi), eosinophilia of ⬎ 10% in peripheral blood, paranasal sinusi ...
CONCERTATM methylphenidate HCl QUALITATIVE AND
... bipolar disorder because of concern for possible induction of a mixed/manic episode in such patients. Treatment emergent psychotic or manic symptoms, eg. Hallucinations, delusional thinking or mania in children and adolescents without a prior history of psychotic illness or mania can be caused by st ...
... bipolar disorder because of concern for possible induction of a mixed/manic episode in such patients. Treatment emergent psychotic or manic symptoms, eg. Hallucinations, delusional thinking or mania in children and adolescents without a prior history of psychotic illness or mania can be caused by st ...
Psychopharmacology
Psychopharmacology (from Greek ψῡχή, psȳkhē, ""breath, life, soul""; φάρμακον, pharmakon, ""drug""; and -λογία, -logia) is the scientific study of the effects drugs have on mood, sensation, thinking, and behavior. It is distinguished from neuropsychopharmacology, which emphasizes the correlation between drug-induced changes in the functioning of cells in the nervous system and changes in consciousness and behavior.The field of psychopharmacology studies a wide range of substances with various types of psychoactive properties, focusing primarily on the chemical interactions with the brain.Psychoactive drugs interact with particular target sites or receptors found in the nervous system to induce widespread changes in physiological or psychological functions. The specific interaction between drugs and their receptors is referred to as ""drug action"", and the widespread changes in physiological or psychological function is referred to as ""drug effect"". These drugs may originate from natural sources such as plants and animals, or from artificial sources such as chemical synthesis in the laboratory.