Pharmacological Activity of Vinca Alkaloids
... Vinorelbine is similar to Vinblastine. It has antitumor activity against breast cancer and can be affective against bone tumor cells, osteosarcoma. In addition, Vinorelbine decreases the stability of lipid bilayer membranes. Side-effects of Vinorelbine include decreased resistance to infection, blee ...
... Vinorelbine is similar to Vinblastine. It has antitumor activity against breast cancer and can be affective against bone tumor cells, osteosarcoma. In addition, Vinorelbine decreases the stability of lipid bilayer membranes. Side-effects of Vinorelbine include decreased resistance to infection, blee ...
Isha Humagain Gaustabbo Ibrra March 31, 2014 Research paper
... Nicotine is absorbed into the body when an individual smokes or chews tobacco. Nicotine causes elevation of mood. This is the principal reason for nicotine causing addiction. The nicotine absorbed by a smoker reaches the brain via blood. This leads to numerous chemical reactions in the brain and cau ...
... Nicotine is absorbed into the body when an individual smokes or chews tobacco. Nicotine causes elevation of mood. This is the principal reason for nicotine causing addiction. The nicotine absorbed by a smoker reaches the brain via blood. This leads to numerous chemical reactions in the brain and cau ...
A comparative study of intrathecal 0.5% hyperbaric bupivacaine with
... Neuraxial opioids provide good analgesia similar to systemic administration, but in small doses and concentrations with less risk of systemic side effects. Intrathecal opioids exert its effect by combining with opioid receptors in the dorsal horn of spinal cord and may have supraspinal spread and ac ...
... Neuraxial opioids provide good analgesia similar to systemic administration, but in small doses and concentrations with less risk of systemic side effects. Intrathecal opioids exert its effect by combining with opioid receptors in the dorsal horn of spinal cord and may have supraspinal spread and ac ...
LA`s - Notes For ANZCA Primary Exam
... Acids are predominantly ionised Above their pKa ; Bases are predominantly ionised Below their pKa One unit (ie 7.9 ⟹ 6.9) away from pKa = 90% Two units away from pKa = 99%. LA02 [Mar96] [Jul04] Cocaine: A. Blocks reuptake of dopamine and noradrenaline euphoria mostly due to central dopamine effects ...
... Acids are predominantly ionised Above their pKa ; Bases are predominantly ionised Below their pKa One unit (ie 7.9 ⟹ 6.9) away from pKa = 90% Two units away from pKa = 99%. LA02 [Mar96] [Jul04] Cocaine: A. Blocks reuptake of dopamine and noradrenaline euphoria mostly due to central dopamine effects ...
EFFECT OF POLOXAMER 188 ON IN VITRO DISSOLUTION
... to inadequate and variable bioavailability1, 2. Based upon their solubility and permeability characteristics, the Biopharmaceutical Classification System (BCS) categorizes drugs in two major classes, class II and IV3. The BCS class II drugs are poorly water-soluble entities with high permeability. T ...
... to inadequate and variable bioavailability1, 2. Based upon their solubility and permeability characteristics, the Biopharmaceutical Classification System (BCS) categorizes drugs in two major classes, class II and IV3. The BCS class II drugs are poorly water-soluble entities with high permeability. T ...
Potential use of melatonin in sleep and delirium in the critically ill
... glutathione and tocopherol (Vitamin E) in scavenging hydroxyl and neutralization of peroxyl radicals, thus reducing cellular damage from reactive oxygen species.20 28 29 This is fundamental to the ageing process. Anti-apoptotic activity has also been described.30 A recent review of the anti-oxidant ...
... glutathione and tocopherol (Vitamin E) in scavenging hydroxyl and neutralization of peroxyl radicals, thus reducing cellular damage from reactive oxygen species.20 28 29 This is fundamental to the ageing process. Anti-apoptotic activity has also been described.30 A recent review of the anti-oxidant ...
Corticosteroids
... Atherosclerosis. The arteries may harden, partly because of an increase in blood sugar and fats. A rise in blood pressure will also contribute, due to water and sodium retention. Osteoporosis. Thinning of the bones, making the hip and spine especially more susceptible to fracture. This can be ag ...
... Atherosclerosis. The arteries may harden, partly because of an increase in blood sugar and fats. A rise in blood pressure will also contribute, due to water and sodium retention. Osteoporosis. Thinning of the bones, making the hip and spine especially more susceptible to fracture. This can be ag ...
Download PDF
... pharmaceutically-active compounds sold each year find their way into the environment as the result of human/animal urine and feces excretion (excreted unchanged drugs or as drug metabolites), direct disposal of unused household drugs by flushing into sewage systems, accidental spills and releases fr ...
... pharmaceutically-active compounds sold each year find their way into the environment as the result of human/animal urine and feces excretion (excreted unchanged drugs or as drug metabolites), direct disposal of unused household drugs by flushing into sewage systems, accidental spills and releases fr ...
Managing hiccups - Canadian Family Physician
... management. A usual dosage would be 25 mg 4 times a day, increasing to 50 mg 4 times a day if needed. Haloperidol: Haloperidol has been shown to be effective, presumably also via dopamine antagonism. It might be better tolerated than chlorpromazine is. Anticonvulsants. Valproic acid enhances GABA ...
... management. A usual dosage would be 25 mg 4 times a day, increasing to 50 mg 4 times a day if needed. Haloperidol: Haloperidol has been shown to be effective, presumably also via dopamine antagonism. It might be better tolerated than chlorpromazine is. Anticonvulsants. Valproic acid enhances GABA ...
human pharmacology of ayahuasca - Multidisciplinary Association
... widely used by the indigenous peoples of northwestern South America. The area of use has been estimated to extend from Panama to Amazonian Peru and Bolivia and from the coastal areas of Colombia and Ecuador to the Río Negro in Brazil (Ott, 1993). While the term ayahuasca, which also designates the p ...
... widely used by the indigenous peoples of northwestern South America. The area of use has been estimated to extend from Panama to Amazonian Peru and Bolivia and from the coastal areas of Colombia and Ecuador to the Río Negro in Brazil (Ott, 1993). While the term ayahuasca, which also designates the p ...
The Glutamatergic System and Alzheimer`s Disease
... Alzheimer’s disease was more oxidised than that isolated and purified from the brains of healthy agematched individuals.[42] A recent study has shown, using proteomics, that glutamine synthetase indeed is oxidised in the brains of individuals with Alzheimer’s disease relative to control individuals. ...
... Alzheimer’s disease was more oxidised than that isolated and purified from the brains of healthy agematched individuals.[42] A recent study has shown, using proteomics, that glutamine synthetase indeed is oxidised in the brains of individuals with Alzheimer’s disease relative to control individuals. ...
Antiepileptic drugs for neuropathic pain and fibromyalgia
... or on the distribution or nature of symptoms (Woolf 1999). Antiepileptics in general are thought to reduce the ability of the neuron to fire at high frequency (Chong 2000). The two standard explanations are enhanced gamma-aminobutyric acid (GABA) inhibition (valproate, clonazepam), or a stabilising ...
... or on the distribution or nature of symptoms (Woolf 1999). Antiepileptics in general are thought to reduce the ability of the neuron to fire at high frequency (Chong 2000). The two standard explanations are enhanced gamma-aminobutyric acid (GABA) inhibition (valproate, clonazepam), or a stabilising ...
Loxamine - Medsafe
... increased risk of suicidal thinking and behaviour in children and adolescents with major depressive disorder and other psychiatric disorders. In clinical trials of paroxetine in children and adolescents, adverse events related to suicidality (suicide attempts and suicidal thoughts) and hostility (pr ...
... increased risk of suicidal thinking and behaviour in children and adolescents with major depressive disorder and other psychiatric disorders. In clinical trials of paroxetine in children and adolescents, adverse events related to suicidality (suicide attempts and suicidal thoughts) and hostility (pr ...
outlineM2bg6.01 - University of Illinois Archives
... Dendritic spines, the postsynaptic protrusions onto which excitatory afferents impinge in central neurons, were described a hundred years ago by Ramon y Cajal, but their role in neuronal functions is still an enigma. Early morphological studies, using high power optical or electron microscopy, found ...
... Dendritic spines, the postsynaptic protrusions onto which excitatory afferents impinge in central neurons, were described a hundred years ago by Ramon y Cajal, but their role in neuronal functions is still an enigma. Early morphological studies, using high power optical or electron microscopy, found ...
![متن کامل [DOC 196 kb] - Basic and Clinical Neuroscience](http://s1.studyres.com/store/data/000600867_1-b94e6dbf4c5d1c7fbf2f36a9f28b9352-300x300.png)
متن کامل [DOC 196 kb] - Basic and Clinical Neuroscience
... Lehtimäki et al., 2003). Because of the central nervous system high lipid content, it is highly susceptible to free-radical-mediated damage and inflammatory reactions that play an important role in the neuronal death processes(Perry et al., 2002; Migliore et al., 2005; Ashrafi et al., 2007). With ex ...
... Lehtimäki et al., 2003). Because of the central nervous system high lipid content, it is highly susceptible to free-radical-mediated damage and inflammatory reactions that play an important role in the neuronal death processes(Perry et al., 2002; Migliore et al., 2005; Ashrafi et al., 2007). With ex ...
Migraine prophylaxis - International Society of Drug Bulletins
... attacks is unknown, although they are thought to inhibit beta-1-mediated mechanisms in the central catecholaminergic system.13 The only beta-blockers approved for migraine prophylaxis by the US Food and Drug Administration (FDA) are propranolol and timolol, but nadolol, atenolol, and metoprolol are ...
... attacks is unknown, although they are thought to inhibit beta-1-mediated mechanisms in the central catecholaminergic system.13 The only beta-blockers approved for migraine prophylaxis by the US Food and Drug Administration (FDA) are propranolol and timolol, but nadolol, atenolol, and metoprolol are ...
Cannabis use and misuse
... high calorie products. At low to moderate doses, cannabis typically has antiemetic effects (reduces nausea), but can induce nausea or vomiting at higher doses or among less experienced users. Cannabis use has a broad range of effects on cardiovascular function. Use is associated with increase in res ...
... high calorie products. At low to moderate doses, cannabis typically has antiemetic effects (reduces nausea), but can induce nausea or vomiting at higher doses or among less experienced users. Cannabis use has a broad range of effects on cardiovascular function. Use is associated with increase in res ...
Molecular Mechanisms Underlying the Acquisition, Extinction and
... cocaine associated memory and levels of NR2B subunit expression. Pharmacologically, the development (acquisition) of Fix-C and Esc-C memory was attenuated by antagonism of NR2B-containing NMDARs. However, inhibition of the neuronal nitric oxide synthase (nNOS) which is downstream of the NMDAR attenu ...
... cocaine associated memory and levels of NR2B subunit expression. Pharmacologically, the development (acquisition) of Fix-C and Esc-C memory was attenuated by antagonism of NR2B-containing NMDARs. However, inhibition of the neuronal nitric oxide synthase (nNOS) which is downstream of the NMDAR attenu ...
Product Monograph Template - Standard
... normocalcaemia has been achieved. Urine output must be maintained to avoid possible fluid overload. As many patients with hypercalcemia have other electrolyte abnormalities at presentation, appropriate attention must be given to maintaining electrolyte balance. For example, for hypokalemia, which ma ...
... normocalcaemia has been achieved. Urine output must be maintained to avoid possible fluid overload. As many patients with hypercalcemia have other electrolyte abnormalities at presentation, appropriate attention must be given to maintaining electrolyte balance. For example, for hypokalemia, which ma ...
Subsys Prescribing Information
... Accidental ingestion of even one dose of SUBSYS especially by children, can result in a fatal overdose of fentanyl [see Warnings and Precautions (5.2 )]. Death has been reported in children who have accidentally ingested transmucosal immediaterelease fentanyl products. SUBSYS must be kept out of rea ...
... Accidental ingestion of even one dose of SUBSYS especially by children, can result in a fatal overdose of fentanyl [see Warnings and Precautions (5.2 )]. Death has been reported in children who have accidentally ingested transmucosal immediaterelease fentanyl products. SUBSYS must be kept out of rea ...
Jemds.com
... Aripiprazole is a third generation antipsychotic introduced in 2004 for treatment of Schizophrenia and bipolar disorders. It has partial agonist activity at dopamine D2 receptor and D2 antagonist activity under hyperdopaminergic condition. In addition, it is a partial agonist at serotonin 5HT1A rece ...
... Aripiprazole is a third generation antipsychotic introduced in 2004 for treatment of Schizophrenia and bipolar disorders. It has partial agonist activity at dopamine D2 receptor and D2 antagonist activity under hyperdopaminergic condition. In addition, it is a partial agonist at serotonin 5HT1A rece ...
Menthol inhibiting parasympathetic function of tracheal smooth muscle
... response observed in this study was probably an aggregate of the responses of various types of muscle tissue. Secondly, the isolated tracheal preparations used in our experiments were excised from rats without damaging the endothelium or smooth muscle. Therefore, it is reasonable to assume that trac ...
... response observed in this study was probably an aggregate of the responses of various types of muscle tissue. Secondly, the isolated tracheal preparations used in our experiments were excised from rats without damaging the endothelium or smooth muscle. Therefore, it is reasonable to assume that trac ...
Current and Potential Drugs for Treatment of Obesity
... review of any drug-treatment protocol. Recently, the FDA in the United States and the Committee for Proprietary Medicinal Products (CPMP) in Europe have proposed more unified protocols. In this review we have used the FDA criterion of a weight loss of more than 5% below placebo and the CPMP criterio ...
... review of any drug-treatment protocol. Recently, the FDA in the United States and the Committee for Proprietary Medicinal Products (CPMP) in Europe have proposed more unified protocols. In this review we have used the FDA criterion of a weight loss of more than 5% below placebo and the CPMP criterio ...
Anabolic Steroids
... When it comes to building muscle, steroids and exercise are an unbeatable combination. Some users claim that steroids even increase aggression, which may be helpful to football players and other competitive athletes. Despite the benefits of steroids, most physicians view them as a dangerous proposit ...
... When it comes to building muscle, steroids and exercise are an unbeatable combination. Some users claim that steroids even increase aggression, which may be helpful to football players and other competitive athletes. Despite the benefits of steroids, most physicians view them as a dangerous proposit ...
Psychopharmacology
Psychopharmacology (from Greek ψῡχή, psȳkhē, ""breath, life, soul""; φάρμακον, pharmakon, ""drug""; and -λογία, -logia) is the scientific study of the effects drugs have on mood, sensation, thinking, and behavior. It is distinguished from neuropsychopharmacology, which emphasizes the correlation between drug-induced changes in the functioning of cells in the nervous system and changes in consciousness and behavior.The field of psychopharmacology studies a wide range of substances with various types of psychoactive properties, focusing primarily on the chemical interactions with the brain.Psychoactive drugs interact with particular target sites or receptors found in the nervous system to induce widespread changes in physiological or psychological functions. The specific interaction between drugs and their receptors is referred to as ""drug action"", and the widespread changes in physiological or psychological function is referred to as ""drug effect"". These drugs may originate from natural sources such as plants and animals, or from artificial sources such as chemical synthesis in the laboratory.