Synergistic interaction between metformin and
... peripheral tissue insulin sensitivity (7,8). Clinical studies have demonstrated that metformin-sulfonylurea combinations produce greater improvements in glycemic control than either sulfonylurea or metformin monotherapies (9-12). However, there are no animal studies that demonstrate a synergic hypog ...
... peripheral tissue insulin sensitivity (7,8). Clinical studies have demonstrated that metformin-sulfonylurea combinations produce greater improvements in glycemic control than either sulfonylurea or metformin monotherapies (9-12). However, there are no animal studies that demonstrate a synergic hypog ...
How to safely prescribe long-acting opioids Feature article
... each receptor. The analgesic effects and the adverse effects from opioid therapy both arise from the drug’s interaction with the receptors. The primary mechanism of action is the alteration of the perception of pain through the mu opioid receptor. This presynaptic inhibition is responsible for decre ...
... each receptor. The analgesic effects and the adverse effects from opioid therapy both arise from the drug’s interaction with the receptors. The primary mechanism of action is the alteration of the perception of pain through the mu opioid receptor. This presynaptic inhibition is responsible for decre ...
PAXIL PRODUCT MONOGRAPH
... Special Patient Populations-Treatment of Pregnant Women During the Third Trimester). Potential for reduced efficacy of Tamoxifen with concomitant SSRI use, including PAXIL® The antitumor agent tamoxifen is a pro-drug requiring metabolic activation by CYP2D6. Inhibition of CYP2D6 can lead to reduced ...
... Special Patient Populations-Treatment of Pregnant Women During the Third Trimester). Potential for reduced efficacy of Tamoxifen with concomitant SSRI use, including PAXIL® The antitumor agent tamoxifen is a pro-drug requiring metabolic activation by CYP2D6. Inhibition of CYP2D6 can lead to reduced ...
Quantum of Effectiveness Evidence in FDA`s Approval of
... the original study, how frequently FDA has required marketing applications of drugs for rare diseases to provide the conventional level of proof of effectiveness that is ordinarily expected for most drugs for prevalent diseases. Methods: This study employed methods similar to the original analysis, ...
... the original study, how frequently FDA has required marketing applications of drugs for rare diseases to provide the conventional level of proof of effectiveness that is ordinarily expected for most drugs for prevalent diseases. Methods: This study employed methods similar to the original analysis, ...
Multi compartment models (Delayed distribution models)
... such a plasma level-time profile determines the no. of kinetically homogeneous compartments into which a drug will distribute. • The simplest and commonest is the two compartment model which classifies the body tissues in two categories : 1. Central compartment or Compartment 1 2. Peripheral or Tiss ...
... such a plasma level-time profile determines the no. of kinetically homogeneous compartments into which a drug will distribute. • The simplest and commonest is the two compartment model which classifies the body tissues in two categories : 1. Central compartment or Compartment 1 2. Peripheral or Tiss ...
International Editorial Board
... initiation of therapy with diuretics or -blockers - these agents have been proven to reduce cardiovascular morbidity and mortality. [2] ACE inhibitors, 1-blockers and calcium antagonists are positioned as 'alternative firstline' strategies in patients in whom diuretics and -blockers are ineffecti ...
... initiation of therapy with diuretics or -blockers - these agents have been proven to reduce cardiovascular morbidity and mortality. [2] ACE inhibitors, 1-blockers and calcium antagonists are positioned as 'alternative firstline' strategies in patients in whom diuretics and -blockers are ineffecti ...
Statin-associated muscle symptoms: impact on statin therapy
... into muscle complaints are not always incorporated within trial methodology. Conversely, the lack of a placebo comparator in observational studies precludes the ability to establish a causal relationship between statin and muscle complaints. The Effects of Statins on Muscle Performance (STOMP) study ...
... into muscle complaints are not always incorporated within trial methodology. Conversely, the lack of a placebo comparator in observational studies precludes the ability to establish a causal relationship between statin and muscle complaints. The Effects of Statins on Muscle Performance (STOMP) study ...
Hepatotoxicity associated with illicit use of anabolic androgenic
... A relevant concern raised by the chronic administration of AAS is the toxic effect on liver9. Since the 1950s, case reports about anabolic steroids occasional effects on the liver such as cholestasis, liver tumors, and peliosis hepatis have been observed and reported in the literature8,23. Neverthel ...
... A relevant concern raised by the chronic administration of AAS is the toxic effect on liver9. Since the 1950s, case reports about anabolic steroids occasional effects on the liver such as cholestasis, liver tumors, and peliosis hepatis have been observed and reported in the literature8,23. Neverthel ...
Endophthalmitis: Current Trends, Drugs and Protocols
... the highly virulent organisms and their toxins can damage the ocular structures within hours. ...
... the highly virulent organisms and their toxins can damage the ocular structures within hours. ...
Carisoprodol: an underrecognized drug of abuse in north India
... initiated carisoprodol to get a better “high” from their preexisting opioid and tobacco use. However, later they experienced the distinct reinforcing effect of carisoprodol and gradually became also dependent on it. Carisoprodol has been reported to have tolerance and antagonist-precipitated withdra ...
... initiated carisoprodol to get a better “high” from their preexisting opioid and tobacco use. However, later they experienced the distinct reinforcing effect of carisoprodol and gradually became also dependent on it. Carisoprodol has been reported to have tolerance and antagonist-precipitated withdra ...
Fig. 1 - BioImpacts
... tissues such as the iris-ciliary body and the retina. Using suitable animal models and drug analyses techniques, drug liberation and distribution can be assessed. PK parameters such as AUC, Tmax and Cmax are normally the ones that are used for the relative bioavailability (the so-called “relative am ...
... tissues such as the iris-ciliary body and the retina. Using suitable animal models and drug analyses techniques, drug liberation and distribution can be assessed. PK parameters such as AUC, Tmax and Cmax are normally the ones that are used for the relative bioavailability (the so-called “relative am ...
Safe Handling of Hazardous Drugs
... a drug which displays one or more of the following characteristics: genotoxicity, carcinogenicity, teratogenicity or fertility impairment, or serious organ or other toxic manifestation at low doses in experimental animals or treated patients. The National Institute of Occupational Safety and Health ...
... a drug which displays one or more of the following characteristics: genotoxicity, carcinogenicity, teratogenicity or fertility impairment, or serious organ or other toxic manifestation at low doses in experimental animals or treated patients. The National Institute of Occupational Safety and Health ...
STADOL NS®
... Butorphanol tartrate is a synthetically derived opioid agonist-antagonist analgesic of the phenanthrene series. The chemical name is (-)-17-(cyclobutylmethyl) morphinan-3, 14-diol [S-(R*,R*)] - 2,3 - dihydroxybutanedioate (1:1) (salt). The molecular formula is C21H29NO2,C4H6O6, which corresponds to ...
... Butorphanol tartrate is a synthetically derived opioid agonist-antagonist analgesic of the phenanthrene series. The chemical name is (-)-17-(cyclobutylmethyl) morphinan-3, 14-diol [S-(R*,R*)] - 2,3 - dihydroxybutanedioate (1:1) (salt). The molecular formula is C21H29NO2,C4H6O6, which corresponds to ...
Corticotropin Releasing Factor-Induced CREB Activation in Striatal
... 1 Graduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota, United States of America, 2 Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota, United States of America ...
... 1 Graduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota, United States of America, 2 Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota, United States of America ...
Evidence for the roles of ... mediators in exercise-induced asthma: the ...
... maximum post-exercise fall in FEY1 than that achieved with terfenadine alone. The drug combination proved to have an inhibitory effect that was less marked than that found with either drug used alone. These results provide strong evidence for the contributory role of both histamine and prostanoids i ...
... maximum post-exercise fall in FEY1 than that achieved with terfenadine alone. The drug combination proved to have an inhibitory effect that was less marked than that found with either drug used alone. These results provide strong evidence for the contributory role of both histamine and prostanoids i ...
How Do Atrial-Selective Drugs Differ From Antiarrhythmic
... associated with multi-organ toxicity. Accordingly, recent studies have focused on agents that selectively affect the atria but not the ventricles. Several atrial-selective approaches have been proposed for the management of AF, including inhibition of the atrial-specific ultrarapid delayed rectified ...
... associated with multi-organ toxicity. Accordingly, recent studies have focused on agents that selectively affect the atria but not the ventricles. Several atrial-selective approaches have been proposed for the management of AF, including inhibition of the atrial-specific ultrarapid delayed rectified ...
Interventional Spine and Pain Procedures in Patients - cmp
... Spine and pain procedures for chronic cancer and noncancer pain patients should be treated differently from regional anesthesia blocks for several reasons. These can be divided into procedurespecific and patient-specific factors. The spectrum of interventional spine and pain procedures is far broade ...
... Spine and pain procedures for chronic cancer and noncancer pain patients should be treated differently from regional anesthesia blocks for several reasons. These can be divided into procedurespecific and patient-specific factors. The spectrum of interventional spine and pain procedures is far broade ...
insulin
... Comparison of pharmacokinetic parameters of sulphonylureas and biguanides A/ Sulphonylureas ...
... Comparison of pharmacokinetic parameters of sulphonylureas and biguanides A/ Sulphonylureas ...
Organic Compound proj
... after synthesizing and testing more than 600 compounds created from these acids, the most active was chosen for a clinical trial. After they found it to be ineffective to treat rheumatoid arthritis they tried other compounds and ended up finding that ibuprofen was the most effective and useful compo ...
... after synthesizing and testing more than 600 compounds created from these acids, the most active was chosen for a clinical trial. After they found it to be ineffective to treat rheumatoid arthritis they tried other compounds and ended up finding that ibuprofen was the most effective and useful compo ...
Proventil
... However, under certain circumstances, e.g., as prophylaxis after myocardial infarction, there may be no acceptable alternatives to the use of beta-adrenergic blocking agents in patients with asthma. In this setting, cardioselective beta blockers could be considered, although they should be administe ...
... However, under certain circumstances, e.g., as prophylaxis after myocardial infarction, there may be no acceptable alternatives to the use of beta-adrenergic blocking agents in patients with asthma. In this setting, cardioselective beta blockers could be considered, although they should be administe ...
Children Tylenol with Flavor Creator
... Healthcare, to assess Canadians' awareness and behaviours when using non-prescription pain relievers. The results highlight the need for better education of consumers about differences between NSAIDs and non-NSAIDs. Medications in the NSAID family include acetylsalicylic acid (ASA -- the active ingr ...
... Healthcare, to assess Canadians' awareness and behaviours when using non-prescription pain relievers. The results highlight the need for better education of consumers about differences between NSAIDs and non-NSAIDs. Medications in the NSAID family include acetylsalicylic acid (ASA -- the active ingr ...
Acute Poisoning with Dapsone – A Case Report
... Acute poisoning from excessive dapsone (4,4-diaminodiphenylsulfone) intake is uncommon in Europe. However, with the increasing use of dapsone for diseases other than leprosy and dermatitis herpetiformis, such as acne vulgaris, psoriasis, and pneumocystis carinii pneumonia infection in acquired immun ...
... Acute poisoning from excessive dapsone (4,4-diaminodiphenylsulfone) intake is uncommon in Europe. However, with the increasing use of dapsone for diseases other than leprosy and dermatitis herpetiformis, such as acne vulgaris, psoriasis, and pneumocystis carinii pneumonia infection in acquired immun ...
![This article was downloaded by:[EBSCOHost EJS Content Distribution]](http://s1.studyres.com/store/data/007847793_2-3fcefc5117b4120046c5cb6c9996a7da-300x300.png)
This article was downloaded by:[EBSCOHost EJS Content Distribution]
... pump and other energy-dependent mechanisms for regulating intracellular ion concentrations. Failure of the sodium-potassium pump allows sodium to flow into the cell, causing cytotoxic oedema and changes in the cell’s ionic balance. The resulting failure of mechanisms also leads to a significant incr ...
... pump and other energy-dependent mechanisms for regulating intracellular ion concentrations. Failure of the sodium-potassium pump allows sodium to flow into the cell, causing cytotoxic oedema and changes in the cell’s ionic balance. The resulting failure of mechanisms also leads to a significant incr ...
Psychopharmacology
Psychopharmacology (from Greek ψῡχή, psȳkhē, ""breath, life, soul""; φάρμακον, pharmakon, ""drug""; and -λογία, -logia) is the scientific study of the effects drugs have on mood, sensation, thinking, and behavior. It is distinguished from neuropsychopharmacology, which emphasizes the correlation between drug-induced changes in the functioning of cells in the nervous system and changes in consciousness and behavior.The field of psychopharmacology studies a wide range of substances with various types of psychoactive properties, focusing primarily on the chemical interactions with the brain.Psychoactive drugs interact with particular target sites or receptors found in the nervous system to induce widespread changes in physiological or psychological functions. The specific interaction between drugs and their receptors is referred to as ""drug action"", and the widespread changes in physiological or psychological function is referred to as ""drug effect"". These drugs may originate from natural sources such as plants and animals, or from artificial sources such as chemical synthesis in the laboratory.