Challenges and opportunities in developing novel
... under various growth conditions [6,7] and more rapid target identification for new compounds via identification of the mutated genes of compoundresistant mutants [8] . Although big pharmaceutical companies have recently become more involved, there has been a lack of a concerted effort over the pas ...
... under various growth conditions [6,7] and more rapid target identification for new compounds via identification of the mutated genes of compoundresistant mutants [8] . Although big pharmaceutical companies have recently become more involved, there has been a lack of a concerted effort over the pas ...
Medications for the Treatment of Sleep Disorders: An Overview
... sleepiness, particularly those who also complain of snoring, will require overnight sleep evaluation (polysomnography) because of the potential diagnosis of obstructive sleep apnea. Obstructive sleep apnea is usually treated with continuous positive airway pressure (CPAP), a system that utilizes pos ...
... sleepiness, particularly those who also complain of snoring, will require overnight sleep evaluation (polysomnography) because of the potential diagnosis of obstructive sleep apnea. Obstructive sleep apnea is usually treated with continuous positive airway pressure (CPAP), a system that utilizes pos ...
International Journal for Pharmaceutical Research Scholars (IJPRS)
... (psyche/mind). Therefore, any mental stress due to any cause has direct impact on skin. Thus, we can say that stress and skin diseases have an eternal relationship with each other. Therefore, any emotional as well as psychosocial stress is recognised as major factor for the onset and exacerbation of ...
... (psyche/mind). Therefore, any mental stress due to any cause has direct impact on skin. Thus, we can say that stress and skin diseases have an eternal relationship with each other. Therefore, any emotional as well as psychosocial stress is recognised as major factor for the onset and exacerbation of ...
Selective Inhibition of Human Solute Carrier Transporters by
... 138 nCi); OCT1, OCT2, and OCT3 ([3H]MPP+ 100 nM, 98.5 nCi); OCTN1 ([3H]L-ergothioneine 5 mM, 40.8 nCi); and OCTN2 ([14C]L-carnitine 5 mM, 6.72 nCi). MKIs were added to confluent cells in dimethylsulfoxide (0.1% final concentration), and uptake was terminated after 8 minutes by rapidly washing the ce ...
... 138 nCi); OCT1, OCT2, and OCT3 ([3H]MPP+ 100 nM, 98.5 nCi); OCTN1 ([3H]L-ergothioneine 5 mM, 40.8 nCi); and OCTN2 ([14C]L-carnitine 5 mM, 6.72 nCi). MKIs were added to confluent cells in dimethylsulfoxide (0.1% final concentration), and uptake was terminated after 8 minutes by rapidly washing the ce ...
Oral Nonprescription Treatment for Insomnia
... sleep problems.26 Eight elderly insomniacs were randomly assigned to receive valerian and were compared to 6 elderly insomniacs given placebo in a parallel-group design. Subjects took valerian (450 mg) or placebo 1 hour before bedtime on study day 1, and on study days 2 through 8, they took valerian ...
... sleep problems.26 Eight elderly insomniacs were randomly assigned to receive valerian and were compared to 6 elderly insomniacs given placebo in a parallel-group design. Subjects took valerian (450 mg) or placebo 1 hour before bedtime on study day 1, and on study days 2 through 8, they took valerian ...
Montelukast
... Description: Singular® may be confused with Sinequan® Pharmacology: The cysteinyl leukotriene type-1 (CysLT1) receptor is found in the human airway (including airway smooth muscle cells and airway macrophages) and on other pro- inflammatory cells (including eosinophils and certain myeloid stem cells ...
... Description: Singular® may be confused with Sinequan® Pharmacology: The cysteinyl leukotriene type-1 (CysLT1) receptor is found in the human airway (including airway smooth muscle cells and airway macrophages) and on other pro- inflammatory cells (including eosinophils and certain myeloid stem cells ...
Medical Marijuana
... became the leading recreational drug. It was refuted in the eighties, when cocaine abuse exploded at the same time marijuana use declined. Another common myth about cannabis is that it kills brain cells. Government officials are now admitting that this is not true. This myth came from a few experime ...
... became the leading recreational drug. It was refuted in the eighties, when cocaine abuse exploded at the same time marijuana use declined. Another common myth about cannabis is that it kills brain cells. Government officials are now admitting that this is not true. This myth came from a few experime ...
MICROSPONGE DELIVERY SYSTEM (MDS): A UNIQUE
... Conventional dermatological products typically provide active ingredients in relatively high concentrations but with a short duration of action. This may lead to a cycle of short term over medication followed by long term under medication. In contrast, microsponge technology allows an even and susta ...
... Conventional dermatological products typically provide active ingredients in relatively high concentrations but with a short duration of action. This may lead to a cycle of short term over medication followed by long term under medication. In contrast, microsponge technology allows an even and susta ...
Paracetamol and codeine phosphate
... Codeine should be administered with great caution in patients with head injury, brain tumour or increased intracranial pressure since codeine may increase the risk of respiratory depression and In addition codeine can produce side effects such as further elevate intracranial pressure. confusion, mio ...
... Codeine should be administered with great caution in patients with head injury, brain tumour or increased intracranial pressure since codeine may increase the risk of respiratory depression and In addition codeine can produce side effects such as further elevate intracranial pressure. confusion, mio ...
Antihistamines in pediatric allergy
... Considering all the above roles of histamine on H1 receptors, it is clear that antiH1antihistamines are the most common drugs used to treat allergic diseases.8 H1 antihistamines are not receptor antagonists as previously thought, but are inverse agonists.9 When neither histamine nor antihistamine is ...
... Considering all the above roles of histamine on H1 receptors, it is clear that antiH1antihistamines are the most common drugs used to treat allergic diseases.8 H1 antihistamines are not receptor antagonists as previously thought, but are inverse agonists.9 When neither histamine nor antihistamine is ...
The Most Dangerous Drug
... public, would refuse to license it. The ingestion of aspirin carries significant risks, and there are The Most Dangerous Drug ...
... public, would refuse to license it. The ingestion of aspirin carries significant risks, and there are The Most Dangerous Drug ...
PROCEDURE
... pupils, constipation, sedation, or coma. There may be depressed appetite, thirst, reflexes and sexual desire, and/or an increased tolerance for pain. Codeine tends to have less drug effects than morphine. Heroin use will cause a staggering gait. (Ref: www.drugabuse.gov/drugpages - 4/8/04) Heroin add ...
... pupils, constipation, sedation, or coma. There may be depressed appetite, thirst, reflexes and sexual desire, and/or an increased tolerance for pain. Codeine tends to have less drug effects than morphine. Heroin use will cause a staggering gait. (Ref: www.drugabuse.gov/drugpages - 4/8/04) Heroin add ...
(HMG-CoA) Reductase Inhibitors
... dispensing of HMG-CoA reductase inhibitors. Additionally, periodic monitoring of hepatic function should occur with HMG-CoA reductase inhibitor administration. Hepatic function should also be reviewed following any dosage increase or medication addition which may potentiate a drug interaction. Infor ...
... dispensing of HMG-CoA reductase inhibitors. Additionally, periodic monitoring of hepatic function should occur with HMG-CoA reductase inhibitor administration. Hepatic function should also be reviewed following any dosage increase or medication addition which may potentiate a drug interaction. Infor ...
Department for Transport - Over-the
... different structures in space, classed as + or -) of chlorpheniramine found that whilst 10mg (-) chlorpheniramine showed no difference from placebo in sleep latency or subjective sleepiness, 10mg (+) chlorpheniramine produced a reduction in sleep latency (time taken to fall asleep) one-and-a-half ho ...
... different structures in space, classed as + or -) of chlorpheniramine found that whilst 10mg (-) chlorpheniramine showed no difference from placebo in sleep latency or subjective sleepiness, 10mg (+) chlorpheniramine produced a reduction in sleep latency (time taken to fall asleep) one-and-a-half ho ...
Nonprescription Pain Relievers
... Nonprescription pain relievers are analgesics that can be bought without a doctor’s order (prescription). Sometimes they are called “over-the-counter” pain remedies. They include aspirin (Bufferin, Ascriptin, Ecotrin), acetaminophen (Anacin-3, Tylenol, Datril), and ibuprofen (Advil, Motrin, Nuprin). ...
... Nonprescription pain relievers are analgesics that can be bought without a doctor’s order (prescription). Sometimes they are called “over-the-counter” pain remedies. They include aspirin (Bufferin, Ascriptin, Ecotrin), acetaminophen (Anacin-3, Tylenol, Datril), and ibuprofen (Advil, Motrin, Nuprin). ...
The rise and fall of the COX-2 inhibitors
... tomoxiprol, meclofenamate, sulindac and diclofenac have a less than five-fold selectivity to COX-2. 9,10 Nimesulide, celecoxib, meloxicam and etodolac have a five to fifty fold selectivity towards COX-2, whilst still producing full inhibition of COX-1. Rofecoxib has a greater than 50fold selectivity ...
... tomoxiprol, meclofenamate, sulindac and diclofenac have a less than five-fold selectivity to COX-2. 9,10 Nimesulide, celecoxib, meloxicam and etodolac have a five to fifty fold selectivity towards COX-2, whilst still producing full inhibition of COX-1. Rofecoxib has a greater than 50fold selectivity ...
1. trade name of the medicinal product gyno
... interactions are unlikely to occur. However, in patients on oral anticoagulants, such as warfarin, caution should be exercised and anticoagulant effect should be monitored. The effects and side effects of some other drugs (e.g., oral hypoglycemics and phenytoin), when co-administered with miconazole ...
... interactions are unlikely to occur. However, in patients on oral anticoagulants, such as warfarin, caution should be exercised and anticoagulant effect should be monitored. The effects and side effects of some other drugs (e.g., oral hypoglycemics and phenytoin), when co-administered with miconazole ...
Isoniazid, rifampicin and pyrazinamide plasma concentrations 2 and
... than expected ranges, could therefore aid in avoiding drug resistance as well as unnecessary costs. In the case of PZA, the majority of our patients had concentrations within the target range, which is perhaps due to the wide reference range for PZA (20–50 μg /ml). The prevalence of low drug plasma ...
... than expected ranges, could therefore aid in avoiding drug resistance as well as unnecessary costs. In the case of PZA, the majority of our patients had concentrations within the target range, which is perhaps due to the wide reference range for PZA (20–50 μg /ml). The prevalence of low drug plasma ...
The over-the-counter pharmaceutical market - policy and practice
... licence (which may be more restricted than the indication for prescribed use), that the potential for drug interactions (with both other OTC and prescribed medicines) is assessed and avoided, and that people with contra-indications are not sold the preparations. Using one of the most frequently sold ...
... licence (which may be more restricted than the indication for prescribed use), that the potential for drug interactions (with both other OTC and prescribed medicines) is assessed and avoided, and that people with contra-indications are not sold the preparations. Using one of the most frequently sold ...
ANTI-SUBSTANCE ABUSE PROGRAMME OF ACTION 2011-2016
... environment. The impact of drinking on family life can include mental health problems for other family members such as anxiety, fear and depression. ...
... environment. The impact of drinking on family life can include mental health problems for other family members such as anxiety, fear and depression. ...
of aspirin
... platelet cyclooxygenase for the life of the platelet (8 to 11 days); in human beings, a daily dose of aspirin as small as 40 mg is sufficient to produce this effect. ANALGESIA: • The types of pain usually relieved by aspirin are those of low intensity that arise from integumental structures rather t ...
... platelet cyclooxygenase for the life of the platelet (8 to 11 days); in human beings, a daily dose of aspirin as small as 40 mg is sufficient to produce this effect. ANALGESIA: • The types of pain usually relieved by aspirin are those of low intensity that arise from integumental structures rather t ...
Introduction to Anabolic Steroids
... more effective than natural levels of AAS. This is true even if use is sustained over time. That however is not consistent with any claims of downregulation of androgen receptors in response to high doses of AAS. It also is justified both from bodybuilding experience and from scientific evidence th ...
... more effective than natural levels of AAS. This is true even if use is sustained over time. That however is not consistent with any claims of downregulation of androgen receptors in response to high doses of AAS. It also is justified both from bodybuilding experience and from scientific evidence th ...
marijuana poisoning - Buffalo Academy of Veterinary Medicine
... Although second-hand smoke exposure is possible, the main route of animal marijuana exposure is through ingestion of the owner’s supply (“stash”).6,10 While smokers of marijuana can control their level of intoxication by how much they smoke, how often they inhale, and since the effects of the active ...
... Although second-hand smoke exposure is possible, the main route of animal marijuana exposure is through ingestion of the owner’s supply (“stash”).6,10 While smokers of marijuana can control their level of intoxication by how much they smoke, how often they inhale, and since the effects of the active ...
Psychopharmacology
Psychopharmacology (from Greek ψῡχή, psȳkhē, ""breath, life, soul""; φάρμακον, pharmakon, ""drug""; and -λογία, -logia) is the scientific study of the effects drugs have on mood, sensation, thinking, and behavior. It is distinguished from neuropsychopharmacology, which emphasizes the correlation between drug-induced changes in the functioning of cells in the nervous system and changes in consciousness and behavior.The field of psychopharmacology studies a wide range of substances with various types of psychoactive properties, focusing primarily on the chemical interactions with the brain.Psychoactive drugs interact with particular target sites or receptors found in the nervous system to induce widespread changes in physiological or psychological functions. The specific interaction between drugs and their receptors is referred to as ""drug action"", and the widespread changes in physiological or psychological function is referred to as ""drug effect"". These drugs may originate from natural sources such as plants and animals, or from artificial sources such as chemical synthesis in the laboratory.