A New Therapeutic Applications for Drug Repositioning
... time to launch [26] and reduced development costs compared with conventionally developed drugs, iii) large numbers of ―druggable‖ compounds sit in libraries with the potential to be repurposed, iv) repurposing technology will see increasing integration as a standard process of resource utilization, ...
... time to launch [26] and reduced development costs compared with conventionally developed drugs, iii) large numbers of ―druggable‖ compounds sit in libraries with the potential to be repurposed, iv) repurposing technology will see increasing integration as a standard process of resource utilization, ...
Full Article-PDF - Pharma Research Library
... release drug delivery employs devices such as polymer based disks, rods, pellets, or microparticles, that encapsulate drug and release it at controlled rates for relatively long periods of time. Such systems offer several potential advantages over traditional methods of administration [4]. Drug rele ...
... release drug delivery employs devices such as polymer based disks, rods, pellets, or microparticles, that encapsulate drug and release it at controlled rates for relatively long periods of time. Such systems offer several potential advantages over traditional methods of administration [4]. Drug rele ...
RCPsych Literature Search OPIOIDS 2010
... improved function to balance the risks associated with their use, however, is unclear. Of particular importance to clinicians treating chronic musculoskeletal pain is opioid-induced hyperalgesia, the activation of pronociceptive pathways by exogenous opioids that results in central sensitization to ...
... improved function to balance the risks associated with their use, however, is unclear. Of particular importance to clinicians treating chronic musculoskeletal pain is opioid-induced hyperalgesia, the activation of pronociceptive pathways by exogenous opioids that results in central sensitization to ...
REMERON PRODUCT MONOGRAPH
... all three cases, the patients recovered after the drug with which they were being treated was stopped. In the post-marketing period with REMERON®, very rare cases of agranulocytosis have been reported, mostly reversible, but in some cases fatal. Fatal cases have mostly concerned patients above 65 ye ...
... all three cases, the patients recovered after the drug with which they were being treated was stopped. In the post-marketing period with REMERON®, very rare cases of agranulocytosis have been reported, mostly reversible, but in some cases fatal. Fatal cases have mostly concerned patients above 65 ye ...
NutraSweet
... assimilation of whole-food proteins containing these amino acids AND aspartame. There is no unbalanced flooding of single amino acids into the system when proteins are slowly digested to produce single amino acids. Consuming phenylalanine as dietary protein does not significantly elevate plasma or b ...
... assimilation of whole-food proteins containing these amino acids AND aspartame. There is no unbalanced flooding of single amino acids into the system when proteins are slowly digested to produce single amino acids. Consuming phenylalanine as dietary protein does not significantly elevate plasma or b ...
Fatal intoxication due to tramadol alone Case report and review of
... thought to have a low potential for abuse, tolerance and dependence [6,9]. Nevertheless, recent reports describe the potential for abuse and the occurrence of seizures and anaphylactoid reactions. Currently tramadol is not recommended for patients with past or present histories of addiction to or de ...
... thought to have a low potential for abuse, tolerance and dependence [6,9]. Nevertheless, recent reports describe the potential for abuse and the occurrence of seizures and anaphylactoid reactions. Currently tramadol is not recommended for patients with past or present histories of addiction to or de ...
The use of clozapine plasma levels in optimising therapy
... are frequently encountered in patients on antipsychotics and are a cause of substantial morbidity. Psychiatric Bulletin (1995), 19, 755-757 ...
... are frequently encountered in patients on antipsychotics and are a cause of substantial morbidity. Psychiatric Bulletin (1995), 19, 755-757 ...
72/2013 - Repatriation Medical Authority
... exposure to a volatile substance from the specified list, with clinically significant problematic behavioural or psychological changes (e.g., belligerence, assaultiveness, apathy, impaired judgement) that developed during or shortly after, exposure, and accompanied by two or more of the following si ...
... exposure to a volatile substance from the specified list, with clinically significant problematic behavioural or psychological changes (e.g., belligerence, assaultiveness, apathy, impaired judgement) that developed during or shortly after, exposure, and accompanied by two or more of the following si ...
Samanta Yubero Lahoz MDMA PHARMACOLOGY IN HUMANS AND SEROTONERGIC EFFECTS
... which is the main responsible of MDMA first-pass metabolism in humans. This phenomenon is associated with a decrease in the amount of effective enzyme such that recovery of activity depends on its de novo synthesis, with a time course dictated by the half-life of the enzyme. Recent clinical data rep ...
... which is the main responsible of MDMA first-pass metabolism in humans. This phenomenon is associated with a decrease in the amount of effective enzyme such that recovery of activity depends on its de novo synthesis, with a time course dictated by the half-life of the enzyme. Recent clinical data rep ...
Pharmacologic_Agents_and_QT_interval_Pro... 3438KB Apr 30
... • Drug Induced QT prolongation and Torsades de Pointes are an increasing public health problem. • The blockade of Ikr potassium current by these drugs responsible for their pro-arrhythmic effect. • Measurement of QT interval should be corrected for Heart Rate. • Antiarrhythmic drugs, non-sedating an ...
... • Drug Induced QT prolongation and Torsades de Pointes are an increasing public health problem. • The blockade of Ikr potassium current by these drugs responsible for their pro-arrhythmic effect. • Measurement of QT interval should be corrected for Heart Rate. • Antiarrhythmic drugs, non-sedating an ...
Monday 23rd December: PSA2
... This will not have any effect on the acute dystonia. Option C Justification This will not have an immediate effect. It would be preferable to substitute an antipsychotic that has less tendency than haloperidol to cause extrapyramidal effects, thereby lessening the likelihood of recurrent dystonia. O ...
... This will not have any effect on the acute dystonia. Option C Justification This will not have an immediate effect. It would be preferable to substitute an antipsychotic that has less tendency than haloperidol to cause extrapyramidal effects, thereby lessening the likelihood of recurrent dystonia. O ...
Effect of Excipients on Oxcarbazepine Release from Modified
... F1 and F2 and the more swelling was observed with the F2 containing HPMC LVCR 100 and is because of low viscosity of the polymer and is a good candidate as a drug release retardant for poorly water soluble drugs like OXC. Based on these results and on MDT values (Table 4) obtained, and the solubilit ...
... F1 and F2 and the more swelling was observed with the F2 containing HPMC LVCR 100 and is because of low viscosity of the polymer and is a good candidate as a drug release retardant for poorly water soluble drugs like OXC. Based on these results and on MDT values (Table 4) obtained, and the solubilit ...
IN SITU IMPLANTS FOR PARENTERAL ADMINISTRATION Research Article
... steady state drug release. The kinetics was evaluated for the both phases by fitting the data in four different kinetic models, namely, Zero order, First order, Higuchi and Korsmeyer‐Peppas. While the burst phase fitted best with Zero order kinetics the steady‐state phase complied more with Hi ...
... steady state drug release. The kinetics was evaluated for the both phases by fitting the data in four different kinetic models, namely, Zero order, First order, Higuchi and Korsmeyer‐Peppas. While the burst phase fitted best with Zero order kinetics the steady‐state phase complied more with Hi ...
Pain Assessment and Management
... Doses greater than 4g per 24 hours are not recommended as they may cause hepatotoxicity. Hepatic disease or heavy alcohol use increases this risk further. On the outpatient basis, patients may not realize their Lortab, Percocet, etc., has acetaminophen included (it is called “apap” on the prescripti ...
... Doses greater than 4g per 24 hours are not recommended as they may cause hepatotoxicity. Hepatic disease or heavy alcohol use increases this risk further. On the outpatient basis, patients may not realize their Lortab, Percocet, etc., has acetaminophen included (it is called “apap” on the prescripti ...
Effect of Ethanolic Pod Extract of Canavalia gladiata
... treatment of peptic ulcer. But on chronic administration of these drugs causes various adverse effects. Therefore, herbal medicines seems to be an alternative due to their fewer adverse effects. Canavalia gladiata commonly called as sword bean belongs to the family fabaceae. Since it has got lot of ...
... treatment of peptic ulcer. But on chronic administration of these drugs causes various adverse effects. Therefore, herbal medicines seems to be an alternative due to their fewer adverse effects. Canavalia gladiata commonly called as sword bean belongs to the family fabaceae. Since it has got lot of ...
Treating Chronic Pain
... Only for non-opioid naïve patients who are not allergic to codeine(metablolite of oxycodone) Resp. depression is a risk in the debilitated elderly ...
... Only for non-opioid naïve patients who are not allergic to codeine(metablolite of oxycodone) Resp. depression is a risk in the debilitated elderly ...
Central Nervous System Side Effects of First- and Second
... and have been used effectively for managing symptoms of allergic rhinitis for ⬎50 years. They are the most commonly prescribed drugs among outpatient doctors in the public service in Singapore.4 The major limitation of the use of first-generation antihistamines is sedation.3 Being lipophilic molecul ...
... and have been used effectively for managing symptoms of allergic rhinitis for ⬎50 years. They are the most commonly prescribed drugs among outpatient doctors in the public service in Singapore.4 The major limitation of the use of first-generation antihistamines is sedation.3 Being lipophilic molecul ...
Advances in Natural and Applied Sciences Phyllanthus emblica graecum
... lowered blood glucose levels in mice by 62.1%. The results are shown in Table 1. The results indicate that the formulation can be used effectively for control of blood sugar levels. The various fruits and seed in the formulation contain compounds with beneficial properties, which are not only benefi ...
... lowered blood glucose levels in mice by 62.1%. The results are shown in Table 1. The results indicate that the formulation can be used effectively for control of blood sugar levels. The various fruits and seed in the formulation contain compounds with beneficial properties, which are not only benefi ...
NUCYNTA® ER: Full Prescribing Information
... Use of NUCYNTA ER in Patients who are not Opioid Tolerant The starting dose for patients who are not opioid tolerant is NUCYNTA ER 50 mg orally twice daily (approximately every 12 hours). Use of higher starting doses in patients who are not opioid tolerant may cause fatal respiratory depression. Co ...
... Use of NUCYNTA ER in Patients who are not Opioid Tolerant The starting dose for patients who are not opioid tolerant is NUCYNTA ER 50 mg orally twice daily (approximately every 12 hours). Use of higher starting doses in patients who are not opioid tolerant may cause fatal respiratory depression. Co ...
LSD-25 as a Discriminative Stimulus for Response
... D-LYSERGIC acid diethylamide (LSD) and related psychedelics induce marked, characteristic changes in perception and mood in man. People report alterations in most modalities [10]. Even though these events may be unique to man, animal models have been used to study the neurochemical/ pharmacological ...
... D-LYSERGIC acid diethylamide (LSD) and related psychedelics induce marked, characteristic changes in perception and mood in man. People report alterations in most modalities [10]. Even though these events may be unique to man, animal models have been used to study the neurochemical/ pharmacological ...
Principles of Pharmacology
... of action is short e.g. t1/2 = 1h drug mostly gone in 4-5 hours -When drug half-life is long drug slowly removed from body and duration of action is long e.g. t1/2 = 60 h drug needs 300 h to be mostly gone from body ...
... of action is short e.g. t1/2 = 1h drug mostly gone in 4-5 hours -When drug half-life is long drug slowly removed from body and duration of action is long e.g. t1/2 = 60 h drug needs 300 h to be mostly gone from body ...
COX-2-selective NSAIDs: New wonder drugs?
... Aspirin and other non-steroidal antiinflammatory drugs (NSAIDs) are one of the most widely used classes of drugs, with both prescription and over the counter sales of the agents contributing to total usage. NSAIDs are believed to act through inhibition of prostaglandin (PG) synthesis secondary to th ...
... Aspirin and other non-steroidal antiinflammatory drugs (NSAIDs) are one of the most widely used classes of drugs, with both prescription and over the counter sales of the agents contributing to total usage. NSAIDs are believed to act through inhibition of prostaglandin (PG) synthesis secondary to th ...
Resveratrol
... The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted a ...
... The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted a ...
Psychopharmacology
Psychopharmacology (from Greek ψῡχή, psȳkhē, ""breath, life, soul""; φάρμακον, pharmakon, ""drug""; and -λογία, -logia) is the scientific study of the effects drugs have on mood, sensation, thinking, and behavior. It is distinguished from neuropsychopharmacology, which emphasizes the correlation between drug-induced changes in the functioning of cells in the nervous system and changes in consciousness and behavior.The field of psychopharmacology studies a wide range of substances with various types of psychoactive properties, focusing primarily on the chemical interactions with the brain.Psychoactive drugs interact with particular target sites or receptors found in the nervous system to induce widespread changes in physiological or psychological functions. The specific interaction between drugs and their receptors is referred to as ""drug action"", and the widespread changes in physiological or psychological function is referred to as ""drug effect"". These drugs may originate from natural sources such as plants and animals, or from artificial sources such as chemical synthesis in the laboratory.