Modern Methods in Drug Discovery
... The search for pharmaceutical drugs used to be rather straight forward until recent times: A wealth of information about the disease, its causes, and the clinical symptoms were readily available. Thus the starting point for the pharmacological therapy was known. Example: inhibition of an enzyme Thus ...
... The search for pharmaceutical drugs used to be rather straight forward until recent times: A wealth of information about the disease, its causes, and the clinical symptoms were readily available. Thus the starting point for the pharmacological therapy was known. Example: inhibition of an enzyme Thus ...
Schizophrenia and the supersensitive synapse
... The number of neurotransmitter receptors per unit volume of a particular brain region has a major influence on transmission. For example, the density of dopamine D2 receptors is elevated by up to 100% in post-mortem human brains from individuals who have died with schizophrenia [20,21] . Such elevat ...
... The number of neurotransmitter receptors per unit volume of a particular brain region has a major influence on transmission. For example, the density of dopamine D2 receptors is elevated by up to 100% in post-mortem human brains from individuals who have died with schizophrenia [20,21] . Such elevat ...
11/3/2014 Psychedelic Drugs Continued
... • Users report increased feelings of empathy, insight, enhanced communication • Adverse reactions are generally physical – including increased heart rate and blood pressure, fatigue, insomnia, muscle tension, loss of motor coordination, and hyperthermia • Malignant hyperthermia of great concern whe ...
... • Users report increased feelings of empathy, insight, enhanced communication • Adverse reactions are generally physical – including increased heart rate and blood pressure, fatigue, insomnia, muscle tension, loss of motor coordination, and hyperthermia • Malignant hyperthermia of great concern whe ...
A1984SU44500001
... "It is of interest that August 3, 1984, will be the twentieth anniversary of the administration of ketamine to human beings. It remains a unique and safe anesthetic agent. However, its major problem in humans is an emergence delirium which this first study clearly described. The reason our paper has ...
... "It is of interest that August 3, 1984, will be the twentieth anniversary of the administration of ketamine to human beings. It remains a unique and safe anesthetic agent. However, its major problem in humans is an emergence delirium which this first study clearly described. The reason our paper has ...
Nicotine and the Central Nervous System
... blood pressure by opposing the effects of catecholamines, but are also associated with antinociception and anxiety reduction. Finally, the stimulation of cortisol by ACTH has been shown to modulate attention and stimulus discrimination and, in more recent research, to diminish the sensitivity of nic ...
... blood pressure by opposing the effects of catecholamines, but are also associated with antinociception and anxiety reduction. Finally, the stimulation of cortisol by ACTH has been shown to modulate attention and stimulus discrimination and, in more recent research, to diminish the sensitivity of nic ...
Lesson 7 Molecules: Student notes
... The antidepressant, prozac, works as a recycling transmitter blocker. Prozac is a drug that blocks serotonin recycling specifically. An unrelated drug, doxepin, blocks recycling of all monoamines. Activity Seven: Molecules that Drugs Bind To - Enzymes Receptors and recycling transporters are protein ...
... The antidepressant, prozac, works as a recycling transmitter blocker. Prozac is a drug that blocks serotonin recycling specifically. An unrelated drug, doxepin, blocks recycling of all monoamines. Activity Seven: Molecules that Drugs Bind To - Enzymes Receptors and recycling transporters are protein ...
Intrathecal adjuvants MGMC
... • reduces the transmission of nociceptive information in the spinal cord • important role in preventing central sensitisation, windup and long term potentiation which are all involved in chronic pain. ...
... • reduces the transmission of nociceptive information in the spinal cord • important role in preventing central sensitisation, windup and long term potentiation which are all involved in chronic pain. ...
3 - Neurobiology of Hearing
... significantly higher in the experimental cats cf. control and baseline MLR measurements. If these two results are shown, then there are significant physiological and behavioural effects on sound localization due to physostigmine. In order to reject the hypothesis, either the success rate or the MLR ...
... significantly higher in the experimental cats cf. control and baseline MLR measurements. If these two results are shown, then there are significant physiological and behavioural effects on sound localization due to physostigmine. In order to reject the hypothesis, either the success rate or the MLR ...
Under-Investigated Indications in Cannabis Therapeutics
... Fig. 3. High-magnification view of different types of CB1 positive cells in the cochlear nucleus. A group of granule cells in the molecular layer of the dorsal cochlear nucleus (DCN) (A); a stellate cell (B), a cartwheel cell (C), a giant cell (D), a fusiform cell (E) and a corn cell (F) in the DCN; a ...
... Fig. 3. High-magnification view of different types of CB1 positive cells in the cochlear nucleus. A group of granule cells in the molecular layer of the dorsal cochlear nucleus (DCN) (A); a stellate cell (B), a cartwheel cell (C), a giant cell (D), a fusiform cell (E) and a corn cell (F) in the DCN; a ...
73737373 - Restless Legs Syndrome Foundation
... compared to saline control, were studied in isofluorane anaesthetized rats (n=8 per group). • Results: – Significant (P<0.001) increases in BOLD signal intensity in several brain regions, including the thalamus and periaqueductal grey (PAG). – Significant (P<0.001) decreases in BOLD signal intensity ...
... compared to saline control, were studied in isofluorane anaesthetized rats (n=8 per group). • Results: – Significant (P<0.001) increases in BOLD signal intensity in several brain regions, including the thalamus and periaqueductal grey (PAG). – Significant (P<0.001) decreases in BOLD signal intensity ...
Anglická výuka
... blockade of DA receptors in the nigrostriatal DA pathway - a drug-induced parkinsonism blockade of DA receptors in the mesolimbic DA pathway - antipsychotic efficacy (especially positive symptoms) blockade of DA receptors in the mesocortical DA pathway - blunting of emotions and cognitive side ...
... blockade of DA receptors in the nigrostriatal DA pathway - a drug-induced parkinsonism blockade of DA receptors in the mesolimbic DA pathway - antipsychotic efficacy (especially positive symptoms) blockade of DA receptors in the mesocortical DA pathway - blunting of emotions and cognitive side ...
A Medicinal Chemistry Perspec8ve on Picking the Right
... A substance will not work unless it is bound -Paul Ehrlich, 1913 ...
... A substance will not work unless it is bound -Paul Ehrlich, 1913 ...
cAlnOfficial Journalofthe c.AmericanHeart cjlssociation
... techniques. In one biochemical method, dopamine receptors are subdivided according to the effects of agonists on the enzyme, adenylate cyclase. Activation of D, receptors results in stimulation of adenylate cyclase; activation of D2 receptors either results in inhibition of adenylate cyclase or has ...
... techniques. In one biochemical method, dopamine receptors are subdivided according to the effects of agonists on the enzyme, adenylate cyclase. Activation of D, receptors results in stimulation of adenylate cyclase; activation of D2 receptors either results in inhibition of adenylate cyclase or has ...
Nicotinic agonist
A nicotinic agonist is a drug that mimics the action of acetylcholine (ACh) at nicotinic acetylcholine receptors (nAChRs). The nAChR is named for its affinity for nicotine.Examples include nicotine (by definition), acetylcholine (the endogenous agonist of nAChRs), choline, epibatidine, lobeline, varenicline and cytisine.