CP47,497-C8 and JWH073, commonly found in `Spice` herbal
... work suggested that a maximal amount of CB1 internalization was usually obtained by 2 to 3 h (Atwood et al., 2010; Daigle et al., 2008). However, JWH073 produced a much slower rate of receptor internalization than either JWH018 or CP47,497-C8 with a 74.2 min (53.7 to 119.7 min) half-life (non-overla ...
... work suggested that a maximal amount of CB1 internalization was usually obtained by 2 to 3 h (Atwood et al., 2010; Daigle et al., 2008). However, JWH073 produced a much slower rate of receptor internalization than either JWH018 or CP47,497-C8 with a 74.2 min (53.7 to 119.7 min) half-life (non-overla ...
Drug-induced amenorrhea: How we do it
... Psychiatrists should follow the treatment guidelines and ask patients questions that would indicate whether or not they might have elevated prolactin: ...
... Psychiatrists should follow the treatment guidelines and ask patients questions that would indicate whether or not they might have elevated prolactin: ...
Recent advances in knowledge about beta
... discoveries regarding beta-adrenergic receptors can be found in numerous review articles (5-14). The biochemical approach. This approach to the study of beta-adrenergic receptors is similar in principle to that of a variety of other hormone and neurotransmitter receptor assays and to many of the pri ...
... discoveries regarding beta-adrenergic receptors can be found in numerous review articles (5-14). The biochemical approach. This approach to the study of beta-adrenergic receptors is similar in principle to that of a variety of other hormone and neurotransmitter receptor assays and to many of the pri ...
Case Presentation - EZ
... Pandharipande PP, Pun BT, Herr DL, et al. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the ...
... Pandharipande PP, Pun BT, Herr DL, et al. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the ...
Tobacco Smoking and Nicotine Neuropsychopharmacology
... are now eight a neuronal genes (a2 through a8). In addition, three neuronal b genes (b2, b3, b4) have been described. The subunit mRNA distribution for each varies considerably throughout the nervous system of different species of animals. The nAChRs are divided into three subfamilies as noted in Ta ...
... are now eight a neuronal genes (a2 through a8). In addition, three neuronal b genes (b2, b3, b4) have been described. The subunit mRNA distribution for each varies considerably throughout the nervous system of different species of animals. The nAChRs are divided into three subfamilies as noted in Ta ...
Drug chirality: Stereoselectivity in the action and disposition
... Neuroprotective- prevents entry of heavy metal ions across blood brain barrier. Neurotoxic at high doses Effects of Gantacurium, a chlorofumarate muscle relaxant, can be rapidly reveresed by L-cysteine. Not been introduced in clinical practice. ...
... Neuroprotective- prevents entry of heavy metal ions across blood brain barrier. Neurotoxic at high doses Effects of Gantacurium, a chlorofumarate muscle relaxant, can be rapidly reveresed by L-cysteine. Not been introduced in clinical practice. ...
Drug and Active Principle:
... If no action potential follows, Ca2+ is taken up by the SR and the myofilaments relax. Clinically important drugs (with the exception of dantrolene) all interfere with neural control of the muscle cell. Centrally acting muscle relaxants, lower muscle tone by augmenting the activity of intraspi ...
... If no action potential follows, Ca2+ is taken up by the SR and the myofilaments relax. Clinically important drugs (with the exception of dantrolene) all interfere with neural control of the muscle cell. Centrally acting muscle relaxants, lower muscle tone by augmenting the activity of intraspi ...
Autonomic - EmergencyPedia
... viii) A young man is injected with an iv drug. He shows a resultant tachycardia, midriasis, normal blood pressure and reduced sweating. The most likely drug is a. nicotinic antagonist – no – would have muscular symptoms b. muscarinic antagonist – this one – eg atropine c. cholinomimitic – would be m ...
... viii) A young man is injected with an iv drug. He shows a resultant tachycardia, midriasis, normal blood pressure and reduced sweating. The most likely drug is a. nicotinic antagonist – no – would have muscular symptoms b. muscarinic antagonist – this one – eg atropine c. cholinomimitic – would be m ...
Smoking Cessation in Psychiatric Patients
... Duration of Treatment There is limited safety data on the use of NRT for longer than 12 weeks. All clinical studies to date have been in patients that have had a desire to quit smoking. Duration of treatment has not been established for smokers that require NRT due to smoking bans. ...
... Duration of Treatment There is limited safety data on the use of NRT for longer than 12 weeks. All clinical studies to date have been in patients that have had a desire to quit smoking. Duration of treatment has not been established for smokers that require NRT due to smoking bans. ...
Clinical uses Chronic Hypertension
... Choice of a β-adrenoceptor antagonist drug • For some diseases (e.g., myocardial infarction, migraine, cirrhosis with varices, and congestive heart failure), it should not be assumed that all members of this class of drugs are interchangeable; the appropriate drug should be selected from those that ...
... Choice of a β-adrenoceptor antagonist drug • For some diseases (e.g., myocardial infarction, migraine, cirrhosis with varices, and congestive heart failure), it should not be assumed that all members of this class of drugs are interchangeable; the appropriate drug should be selected from those that ...
12th Conference in Advanced Medicinal Chemistry
... Department of Medicinal Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, Greece Dear Invited Speakers and Colleagues, Since I joined this department, in 1976, coming from the University of London (A.H Beckett) and University of Montreal (H. Selye), my main preoccupation was to ...
... Department of Medicinal Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, Greece Dear Invited Speakers and Colleagues, Since I joined this department, in 1976, coming from the University of London (A.H Beckett) and University of Montreal (H. Selye), my main preoccupation was to ...
Falling - Dr Ted Williams
... Very few head-to-head trials Select agent based on tolerance, no demonstrated difference in side effect profiles between agents ...
... Very few head-to-head trials Select agent based on tolerance, no demonstrated difference in side effect profiles between agents ...
Nicotinic agonist
A nicotinic agonist is a drug that mimics the action of acetylcholine (ACh) at nicotinic acetylcholine receptors (nAChRs). The nAChR is named for its affinity for nicotine.Examples include nicotine (by definition), acetylcholine (the endogenous agonist of nAChRs), choline, epibatidine, lobeline, varenicline and cytisine.