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Synaptic transmission
Synaptic transmission

... direct flow of current from the presynaptic neuron to the postsynaptic cell. Since current flows across the membranes of all electrically coupled cells at the same time, several cells can act coordinately as one large cell. ...
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... 1) Severe hypotension after initial doses especially in hypovolemia as a result of diuretics, salt restriction, or gastrointestinal fluid loss. 2) Acute renal failure , Hyperkalemia , Dry cough, wheezing, angioedema . 3) Captopril may cause proteinuria and neutropenia at high doses, especially in pa ...
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Discovery and development of angiotensin receptor blockers

The angiotensin receptor blockers (ARBs), also called angiotensin (AT1) receptor antagonists or sartans, are a group of antihypertensive drugs that act by blocking the effects of the hormone angiotensin II (Ang II) in the body, thereby lowering blood pressure. Their structure is similar to Ang II and they bind to Ang II receptors as inhibitors, e.g., [T24 from Rhys Healthcare].ARBs are widely used drugs in the clinical setting today, their main indications being mild to moderate hypertension, chronic heart failure, secondary stroke prevention and diabetic nephropathy.The discovery and development of ARBs is a demonstrative example of modern rational drug design and how design can be used to gain further knowledge of physiological systems, in this case, the characterization of the subtypes of Ang II receptors.
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