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Kwartaalbericht
Kwartaalbericht

Assessment of the Influence of Histaminergic Actions on Cocaine
Assessment of the Influence of Histaminergic Actions on Cocaine

... the locomotor stimulant effects of cocaine. In addition, a second generation of compounds was synthesized that had reduced muscarinic affinity (Agoston et al., 1997). These compounds also possessed a reduced cocaine-like spectrum of behavioral effects (Katz et al., 2004), suggesting that the antimus ...
Easthope SE, Jarvis B
Easthope SE, Jarvis B

No Slide Title
No Slide Title

Adrenergic_antagonists
Adrenergic_antagonists

Unit I
Unit I

Folate receptor β: a novel target for therapeutic intervention in
Folate receptor β: a novel target for therapeutic intervention in

MedChem5_LeadDevelopment
MedChem5_LeadDevelopment

STUDY OF THE NEUROMODULATORY EFFECTS OF DOPAMINE
STUDY OF THE NEUROMODULATORY EFFECTS OF DOPAMINE

Functional Characterization of GABAA Receptors in Neonatal
Functional Characterization of GABAA Receptors in Neonatal



Benzodiazepines
Benzodiazepines

Morphine HO-  Group is needed for activity HO
Morphine HO- Group is needed for activity HO

Stereochemistry
Stereochemistry

FinMedChem2011
FinMedChem2011

... sensory procession, and mood and stimulant-induced locomotor activity. In vivo studies with subtype selective α2C-antagonists has given further evidence about the role and significance of this receptor in neuropsychiatric disorders, such as cognitive disorders in Alzheimer’s disease and negative sym ...


A. Glucocorticoid drugs
A. Glucocorticoid drugs

Synergistic Interaction between the Two Mechanisms of Action of
Synergistic Interaction between the Two Mechanisms of Action of

rav
rav

rav - PHSI
rav - PHSI

...  Amiodarone and verapamil can increase the plasma concentration of digoxin by inhibiting its excretion. ...
Problem Set 2: Cephalosporins: KEY Answer the following
Problem Set 2: Cephalosporins: KEY Answer the following

Pharmacodynamics of Selective Androgen Receptor
Pharmacodynamics of Selective Androgen Receptor

Type-1 angiotensin receptor signaling in central nervous system
Type-1 angiotensin receptor signaling in central nervous system

... [21], suggesting that blockade of Nox activation could have therapeutic benefits in these diseases. The vasoconstricting effects of angiotensin II (Ang II) on peripheral blood vessels occur via Nox-mediated production of superoxide anions by vascular smooth muscle cells [22, 23]. As a result, select ...
Saw Palmetto Botany
Saw Palmetto Botany

Saw Palmetto Botany
Saw Palmetto Botany

< 1 ... 17 18 19 20 21 22 23 24 25 ... 85 >

Discovery and development of angiotensin receptor blockers

The angiotensin receptor blockers (ARBs), also called angiotensin (AT1) receptor antagonists or sartans, are a group of antihypertensive drugs that act by blocking the effects of the hormone angiotensin II (Ang II) in the body, thereby lowering blood pressure. Their structure is similar to Ang II and they bind to Ang II receptors as inhibitors, e.g., [T24 from Rhys Healthcare].ARBs are widely used drugs in the clinical setting today, their main indications being mild to moderate hypertension, chronic heart failure, secondary stroke prevention and diabetic nephropathy.The discovery and development of ARBs is a demonstrative example of modern rational drug design and how design can be used to gain further knowledge of physiological systems, in this case, the characterization of the subtypes of Ang II receptors.
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