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Pharmacology
Pharmacology

Structure-based drug design strategies in medicinal
Structure-based drug design strategies in medicinal

The UNSIN Report
The UNSIN Report

Nefazodone in the rat: mimicry and antagonism of [À]-DOM
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Rifamycins and Cardiovascular Agents: Drug
Rifamycins and Cardiovascular Agents: Drug

... General Tuberculosis (TB) Therapy Information Many cardiovascular agents are metabolized via the Cytocrhome P450 (CYP450) enzymatic system in the liver. Rifampin is a potent inducer of the Cytochrome P450 and acctounts for the many of the drug interactions that occur during TB therapy. Rifabutin is ...
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... early 1990s and are named so because they were first found to activate the same receptors as natural cannabinoids. The two most widely studied endocannabinoids are N-arachidonoylethanolamide (AEA), also called anandamide [36], and 2-arachidonoylglycerol (2-AG) [37, 38]. It should be noted that AEA c ...
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... formulated product: 20 tablets (each containing 32 mg, 16 mg, 8 mg, 4 mg and 2 mg of candesartan cilexetil, respectively) were crushed using mortar and pestle and intimately mixed. Quantity equivalent to 50 mg of drug was weighed accurately and dissolved in 100 mL of diluent by 20 min sonication. Th ...
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4) Removal of poison/toxic agent from the body Antidotes

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Effects of endocannabinoid neurotransmission modulators on brain

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Morphine - Fakultas Farmasi Unand

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Pharmacokinetic–pharmacodynamic modelling of the hypothermic
Pharmacokinetic–pharmacodynamic modelling of the hypothermic

752ANSModule1_2005
752ANSModule1_2005

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Discovery and development of angiotensin receptor blockers

The angiotensin receptor blockers (ARBs), also called angiotensin (AT1) receptor antagonists or sartans, are a group of antihypertensive drugs that act by blocking the effects of the hormone angiotensin II (Ang II) in the body, thereby lowering blood pressure. Their structure is similar to Ang II and they bind to Ang II receptors as inhibitors, e.g., [T24 from Rhys Healthcare].ARBs are widely used drugs in the clinical setting today, their main indications being mild to moderate hypertension, chronic heart failure, secondary stroke prevention and diabetic nephropathy.The discovery and development of ARBs is a demonstrative example of modern rational drug design and how design can be used to gain further knowledge of physiological systems, in this case, the characterization of the subtypes of Ang II receptors.
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