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Facilitative effects of an adenosine A1/A2 receptor blockade on
Facilitative effects of an adenosine A1/A2 receptor blockade on

Further Characterization of Quinpirole
Further Characterization of Quinpirole

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Document

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Reversal_Agents_in_Sedation_and_Anesthesia-A Review

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Psychopharmacology

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Prodrugs: Effective Solutions for Solubility, Permeability and

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Post-operative Nausea and Vomiting - Vanderbilt University Medical

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Psychopharmacology

...  Nicotinic receptor: • An ionotropic acetylcholine receptor that is stimulated by nicotine and blocked by curare.  Muscarinic receptor: • A metabotropic acetylcholine receptor that is stimulated by muscarine and blocked by ...
Pharmacological treatment of schizophrenia–a review of progress
Pharmacological treatment of schizophrenia–a review of progress

... reviewed available data derived from brain studies) and is one of the most popular target systems for drug development in schizophrenia. The noradrenergic theory of schizophrenia has its basis on the observation that locus coeruleus noradrenaline neurons can affect executive and cognitive function ...
Atropine
Atropine

... rate), asystole and pulseless electrical activity (PEA) in cardiac arrest. This works because the main action of the vagus nerve of the parasympathetic system on the heart is to decrease heart rate. Atropine blocks this action and, therefore, may speed up the heart rate. However, in the latest guide ...
Muscarinic antagonist
Muscarinic antagonist

... rate), asystole and pulseless electrical activity (PEA) in cardiac arrest. This works because the main action of the vagus nerve of the parasympathetic system on the heart is to decrease heart rate. Atropine blocks this action and, therefore, may speed up the heart rate. However, in the latest guide ...
Biospectra Analysis: Model Proteome
Biospectra Analysis: Model Proteome

5F-APINACA (5F-AKB-48) Review Report
5F-APINACA (5F-AKB-48) Review Report

The statin class of HMGA CoA reductase inhibitors demonstrate
The statin class of HMGA CoA reductase inhibitors demonstrate

... compounds, again sharing structural similarities, such as a common fluoride side group (Figure 1). In general, statins are administered in their active form, and are readily absorbed by passive diffusion. However, both simvastatin and lovastatin are administered as inactive lactone prodrugs, which a ...
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bureau of tenncare - Magellan Health Services || TennCare Portal

NMDA Receptor Antagonists
NMDA Receptor Antagonists

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IDrugs The Investigational Drugs Journal

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1. An introduction to drugs, their action and discovery

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Hydrophobic interactions of phenoxazine modulators with bovine

... experiments. The experiments were performed on a 20 × 1⋅3 cm column of sephadexR G50 fine (Pharmacia) at 22°C, equilibrated with standard buffer solution. The flow rate was maintained at 25 ml/h. BSA solution (20 ml, 1%) containing 1⋅0 × 10–4 M phenoxazine modulator, after incubation at 37°C for 6 h ...
The Role of The A2A Receptor in Cell Apoptosis Caused by MDMA
The Role of The A2A Receptor in Cell Apoptosis Caused by MDMA

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Cholinergic and Anti

Thromboxane Receptors Antagonists and/or Synthase Inhibitors
Thromboxane Receptors Antagonists and/or Synthase Inhibitors

Volume 48 Number 4
Volume 48 Number 4

... ASPET continues its leading advocacy to increase training for integrative organ systems pharmacology. ASPET is also committed to making significant contributions through its new affiliation with The FDA Alliance to increase funding for the agency, and as always, we are continuing to work in partners ...
Spectrophotometric Determination of Lorsartan Potassium
Spectrophotometric Determination of Lorsartan Potassium

... and phosphate buffer solution (pH 3-4) as a diluting agent was developed. The developed colour shows maximum absorbance at 620 nm and it was observed that the absorbance of different dilution from the plots the calibration curve between the concentrations in x-axis, absorbance at y-axis. The recover ...
Reversible and regionally selective downregulation of brain
Reversible and regionally selective downregulation of brain

... cannabis smokers than in healthy subjects in cortical, but not in subcortical brain regions. VT was also negatively correlated with years of cannabis smoking: subjects who had smoked cannabis longer had lower VT than subjects who had smoked for a shorter time. Finally, VT increased in cannabis smoke ...
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Discovery and development of angiotensin receptor blockers

The angiotensin receptor blockers (ARBs), also called angiotensin (AT1) receptor antagonists or sartans, are a group of antihypertensive drugs that act by blocking the effects of the hormone angiotensin II (Ang II) in the body, thereby lowering blood pressure. Their structure is similar to Ang II and they bind to Ang II receptors as inhibitors, e.g., [T24 from Rhys Healthcare].ARBs are widely used drugs in the clinical setting today, their main indications being mild to moderate hypertension, chronic heart failure, secondary stroke prevention and diabetic nephropathy.The discovery and development of ARBs is a demonstrative example of modern rational drug design and how design can be used to gain further knowledge of physiological systems, in this case, the characterization of the subtypes of Ang II receptors.
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