log P
... How to see whether the relationship is meaningful? 1. by observing ‘goodness of fit’ Regression or correlation coefficient (r) tells how well the equation explains the variance in activity in terms of physicochemical parameters (usually quoted as r2) If r=1, a perfect fit (observed=calculated activi ...
... How to see whether the relationship is meaningful? 1. by observing ‘goodness of fit’ Regression or correlation coefficient (r) tells how well the equation explains the variance in activity in terms of physicochemical parameters (usually quoted as r2) If r=1, a perfect fit (observed=calculated activi ...
Pharmacology and Therapeutics
... relate specifically to the variation with time of drug concentration in the blood (or plasma) and rates of change. Observed blood concentrations are fitted to mathematical model systems and then useful parameters are derived that give information about a drug’s journey through the body. Over the yea ...
... relate specifically to the variation with time of drug concentration in the blood (or plasma) and rates of change. Observed blood concentrations are fitted to mathematical model systems and then useful parameters are derived that give information about a drug’s journey through the body. Over the yea ...
Back_to_basics_pharmacology 1, 2 and 3 2011
... – Risk of accumulation of toxic metabolite normeperidine which could lead to anxiety, tremors, myoclonus, seizures with repeated doses – Limit its use to less than a day or two – Not useful for cough or diarrhea ...
... – Risk of accumulation of toxic metabolite normeperidine which could lead to anxiety, tremors, myoclonus, seizures with repeated doses – Limit its use to less than a day or two – Not useful for cough or diarrhea ...
Endocrine aspects of anabolic steroids
... showed no change in plasma concentrations in prostatespecific antigen, and the prostatic transverse diameter increased by only 14% [16]. The serious hepatic abnormalities are virtually always associated with the orally active 17a-alkylated androgens such as methyltestosterone, methandrostenolone, ox ...
... showed no change in plasma concentrations in prostatespecific antigen, and the prostatic transverse diameter increased by only 14% [16]. The serious hepatic abnormalities are virtually always associated with the orally active 17a-alkylated androgens such as methyltestosterone, methandrostenolone, ox ...
