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chronic pain

... of noxious signals, the pain that is experienced is often increased in amplitude and duration. In all cases, the pain is maladaptive-- it serves no useful purpose, and significantly impairs the quality of life of the patient. Treatment of chronic pain can be problematic. Many forms of it become “res ...
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NK1 receptor antagonist

Neurokinin 1 (NK1) antagonists are a novel class of medications that possesses unique antidepressant, anxiolytic, and antiemetic properties. The discovery of neurokinin 1 (NK1) receptor antagonists was a turning point in the prevention of nausea and vomiting associated with cancer chemotherapy.An example of a drug in this class is aprepitant. Chemotherapy-induced emesis appears to consist of acute and delayed phases. So far, the acute phase emesis responds to 5-HT3 antagonists while the delayed phase remains difficult to control. The discovery and development of NK1 receptor antagonists have elicited antiemetic effect in both acute and especially in delayed phases of emesis.The first registered clinical use of NK1 receptor antagonists was the treatment of emesis, associated with cancer chemotherapy.
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