Ionisation
... This principle also applies to the physical properties of drug molecules. If a compound is too lipophilic, it may be insoluble in aqueous media (e.g. gastrointestinal fluid or blood) bind too strongly to plasma proteins and therefore the free blood concentration will be too low to produce the de ...
... This principle also applies to the physical properties of drug molecules. If a compound is too lipophilic, it may be insoluble in aqueous media (e.g. gastrointestinal fluid or blood) bind too strongly to plasma proteins and therefore the free blood concentration will be too low to produce the de ...
07 Rhinitis & cough
... o Non-pharmacological therapy – Avoidance of irritants/ allergen – Dusting/vacuuming; washing of bed sheets – Intake of fluids ...
... o Non-pharmacological therapy – Avoidance of irritants/ allergen – Dusting/vacuuming; washing of bed sheets – Intake of fluids ...
Dear Parents of A Smith, Your child currently has a final 9
... i. Occur in 15% of patients- lasts 15-20 minutes ii. May be visual or sensory iii. Migraine without aura- aka common headache- may be accompanied by photophobia, nausea and vomiting III. General approach to treatment of migraines A. Goals of long term migraine treatment (prophylaxis) a. Reduce frequ ...
... i. Occur in 15% of patients- lasts 15-20 minutes ii. May be visual or sensory iii. Migraine without aura- aka common headache- may be accompanied by photophobia, nausea and vomiting III. General approach to treatment of migraines A. Goals of long term migraine treatment (prophylaxis) a. Reduce frequ ...
Antihypertensives:
... of the central pore of the receptor to chloride ions increases, allowing more ions to enter into the neuron and decreasing excitability. Drugs that act as agonists at this receptor are used mostly, but not exclusively, in sleep and anxiety disorders. These receptors are primarily composed of ?, ? an ...
... of the central pore of the receptor to chloride ions increases, allowing more ions to enter into the neuron and decreasing excitability. Drugs that act as agonists at this receptor are used mostly, but not exclusively, in sleep and anxiety disorders. These receptors are primarily composed of ?, ? an ...
Pharmacology Drug List example
... Suppress cough by acting on CNS or peripherally Decreases cough reflex ...
... Suppress cough by acting on CNS or peripherally Decreases cough reflex ...
Pharmacodynamics – How Drugs Work
... A full agonist is one that is capable of producing a maximal response, when it binds to a sufficient number of receptors. In contrast, a partial agonist cannot produce the maximal response of which the tissue is capable, even when it binds to the same number of receptors as a full agonist binds to w ...
... A full agonist is one that is capable of producing a maximal response, when it binds to a sufficient number of receptors. In contrast, a partial agonist cannot produce the maximal response of which the tissue is capable, even when it binds to the same number of receptors as a full agonist binds to w ...
Revisiting AMPA Receptors as an Antiepileptic Drug Target
... therefore recognizes the three families of ionotropic glutamate receptors noted above (NMDA, kainate and quisqualate), except that when quisqualate was found to activate certain metabotropic glutamate receptors—a family of G protein-coupled receptors distinct from ionotropic glutamate receptors that ...
... therefore recognizes the three families of ionotropic glutamate receptors noted above (NMDA, kainate and quisqualate), except that when quisqualate was found to activate certain metabotropic glutamate receptors—a family of G protein-coupled receptors distinct from ionotropic glutamate receptors that ...
Revisiting AMPA receptors as an antiepileptic drug target
... therefore recognizes the three families of ionotropic glutamate receptors noted above (NMDA, kainate and quisqualate), except that when quisqualate was found to activate certain metabotropic glutamate receptors—a family of G protein-coupled receptors distinct from ionotropic glutamate receptors that ...
... therefore recognizes the three families of ionotropic glutamate receptors noted above (NMDA, kainate and quisqualate), except that when quisqualate was found to activate certain metabotropic glutamate receptors—a family of G protein-coupled receptors distinct from ionotropic glutamate receptors that ...
Chapter_005
... Fig. 5-2. Dose-response curves demonstrating efficacy and potency. A, Efficacy, or “maximal efficacy,” is an index of the maximal response a drug can produce. The efficacy of a drug is indicated by the height of its dose-response curve. In this example, meperidine has greater efficacy than pentazoc ...
... Fig. 5-2. Dose-response curves demonstrating efficacy and potency. A, Efficacy, or “maximal efficacy,” is an index of the maximal response a drug can produce. The efficacy of a drug is indicated by the height of its dose-response curve. In this example, meperidine has greater efficacy than pentazoc ...
2002
... The procedure for studying discriminative stimulus effects in morphine-treated monkeys has been described previously (France and Woods, 1989). Daily sessions are comprised of a 10-min time out during which lever presses have no programmed consequence and a 5-min response period during which green st ...
... The procedure for studying discriminative stimulus effects in morphine-treated monkeys has been described previously (France and Woods, 1989). Daily sessions are comprised of a 10-min time out during which lever presses have no programmed consequence and a 5-min response period during which green st ...
Antipsychotic/Neuroleptic Agents and Lithium
... brain i. Mesolimbic pathway is important in the integration of human’s behaviour ii. All humans have irrational thought, but it doesn’t take into serious matter as it is easily swept away iii. But in the increase in the activity of the Mesolimbic pathway, the irrational is somehow taken seriously an ...
... brain i. Mesolimbic pathway is important in the integration of human’s behaviour ii. All humans have irrational thought, but it doesn’t take into serious matter as it is easily swept away iii. But in the increase in the activity of the Mesolimbic pathway, the irrational is somehow taken seriously an ...
Principles of Structure-Based Design
... Note: A lead (i.e. the "leading" compound) in drug discovery is a chemical compound that has pharmacological or biological activity and whose chemical structure is used as a starting point for chemical modifications in order to improve potency, selectivity, or pharmacokinetic parameters. ...
... Note: A lead (i.e. the "leading" compound) in drug discovery is a chemical compound that has pharmacological or biological activity and whose chemical structure is used as a starting point for chemical modifications in order to improve potency, selectivity, or pharmacokinetic parameters. ...
Practical I
... Because of the importance of this receptor in mediating gastric acid release, M1 antagonists such as pirenzepine help patients with ulcer disease or gastric acid hypersecretion. ...
... Because of the importance of this receptor in mediating gastric acid release, M1 antagonists such as pirenzepine help patients with ulcer disease or gastric acid hypersecretion. ...
San Francisco Designer Drug that was supposed to mimic heroin
... heroin withdrawal occurs within 48-72 hours in 50-80% of infants Methadone withdrawal may be delayed up to ...
... heroin withdrawal occurs within 48-72 hours in 50-80% of infants Methadone withdrawal may be delayed up to ...
Anti-Migraine Drugs
... New 5-HT agonists • All designed to penetrate BBB – Can better bind 5-HT receptors in brain as agonist to stimulate constriction – BUT, also should have the least possible vasoconstrictive effects on coronary arteries ...
... New 5-HT agonists • All designed to penetrate BBB – Can better bind 5-HT receptors in brain as agonist to stimulate constriction – BUT, also should have the least possible vasoconstrictive effects on coronary arteries ...
Chemical Synapses activity and project
... another cell. This second cell may be another neuron, muscle cell or glandular cell. If the second cell is a neuron, it is called the postsynaptic neuron. The majority of synapses are chemical synapses which function by releasing a chemical called a neurotransmitter from the presynaptic neuron. Over ...
... another cell. This second cell may be another neuron, muscle cell or glandular cell. If the second cell is a neuron, it is called the postsynaptic neuron. The majority of synapses are chemical synapses which function by releasing a chemical called a neurotransmitter from the presynaptic neuron. Over ...
Opiate receptors, endogenous opioid systems in brain, Analgesia
... Descending Projections from R aphe' N. To Reticular Formation, ...
... Descending Projections from R aphe' N. To Reticular Formation, ...
Anithypertensive_drugs_and_its_classifications
... ◦ Peripheral sympatholytic drugs such as alphaadrenoceptor and beta-adrenoceptor antagonists block the influence of norepinephrine at the effector organ (heart or blood vessel) ◦ Ganglionic blockers that block impulse transmission at the sympathetic ganglia ◦ Block sympathetic activity within the br ...
... ◦ Peripheral sympatholytic drugs such as alphaadrenoceptor and beta-adrenoceptor antagonists block the influence of norepinephrine at the effector organ (heart or blood vessel) ◦ Ganglionic blockers that block impulse transmission at the sympathetic ganglia ◦ Block sympathetic activity within the br ...
Autonomic Nervous System
... mood inappropriation, paranoia (persecution mania) and hallucinations (voices) and Negative symptoms: withdrawal from society, flattened emotional responses, defect in selective attention (can’t distinguish between important and insignificant) Affects up to 1% of population, high suicide rate (10%) ...
... mood inappropriation, paranoia (persecution mania) and hallucinations (voices) and Negative symptoms: withdrawal from society, flattened emotional responses, defect in selective attention (can’t distinguish between important and insignificant) Affects up to 1% of population, high suicide rate (10%) ...
Targets and the Renin Angiotensin Aldosterone System
... Bradykinin‐specific treatment may decrease ...
... Bradykinin‐specific treatment may decrease ...
Lecture Contents -
... – Pharmacology meant activity and side effect profiling in animals, – Preclinics meant dose finding in animals ...
... – Pharmacology meant activity and side effect profiling in animals, – Preclinics meant dose finding in animals ...