Pituitary Hormones
... Hypothalamic lesion or removal → ↓ Ant. Pit H’s except PRL Hypothalamic stimulation → ↑ Ant. Pit H’s except PRL TSH ↑ T3 & T4 through ↑ cAMP, ↑ Iodine uptake ↑ iodination and hydrolysis of thyroglobulin ** diagnostic use ...
... Hypothalamic lesion or removal → ↓ Ant. Pit H’s except PRL Hypothalamic stimulation → ↑ Ant. Pit H’s except PRL TSH ↑ T3 & T4 through ↑ cAMP, ↑ Iodine uptake ↑ iodination and hydrolysis of thyroglobulin ** diagnostic use ...
Control Mechanisms of the GI Tract
... based on the theory that some forms of diarrhea are caused by disruption of the normal bacterial flora of the GI tract – Must be refrigerated to maintain the viability of the bacteria – Examples: • Plain yogurt with active cultures • Variety of trade-name products ...
... based on the theory that some forms of diarrhea are caused by disruption of the normal bacterial flora of the GI tract – Must be refrigerated to maintain the viability of the bacteria – Examples: • Plain yogurt with active cultures • Variety of trade-name products ...
Pellow, S., File, S.E. (1986). Anxiolytic and anxiogenic drug effects
... effect of these compounds on locomotion activity of animals and it is relate to effects of these compounds on anxiety, because AM251, Prazosin and AM251+Prazosin did not affect the number of closed arms entry. In this study antagonist of cannabinoid system increased anxiety of animals, while adrener ...
... effect of these compounds on locomotion activity of animals and it is relate to effects of these compounds on anxiety, because AM251, Prazosin and AM251+Prazosin did not affect the number of closed arms entry. In this study antagonist of cannabinoid system increased anxiety of animals, while adrener ...
Pharmacology II - 2-22
... • Which of the following is true of antipsychotics? a. High potency typicals have a reduced risk of EPS b. Low potency typicals are less efficacious than higher potency antipsychotics c. Atypical antipsychotics have increased affinity for D2 as compared to typical antipsychotics d. Increased antich ...
... • Which of the following is true of antipsychotics? a. High potency typicals have a reduced risk of EPS b. Low potency typicals are less efficacious than higher potency antipsychotics c. Atypical antipsychotics have increased affinity for D2 as compared to typical antipsychotics d. Increased antich ...
Caffeine
... hallucinogenic properties depend on the agonist activity at the 5-HT2A-receptor considered neurotoxic in humans MDMA destroys axonal processes in ...
... hallucinogenic properties depend on the agonist activity at the 5-HT2A-receptor considered neurotoxic in humans MDMA destroys axonal processes in ...
Barbiturate
... Other sedative and hypnotic agents:Buspirone: The actions of buspirone appear to be mediated by serotonin (5-HT1A) receptors, although other receptors could be involved. Because buspirone displays some affinity for DA2 dopamine receptors and 5-HT2A serotonin receptors. Thus, its mode of action diffe ...
... Other sedative and hypnotic agents:Buspirone: The actions of buspirone appear to be mediated by serotonin (5-HT1A) receptors, although other receptors could be involved. Because buspirone displays some affinity for DA2 dopamine receptors and 5-HT2A serotonin receptors. Thus, its mode of action diffe ...
Withdrawal
... 1. Receptor Downregulation- Opioid receptors in the body are actively reduced due to overexposure to opioids. This can also have an effect on endogenous opioid peptide function (i.e. regular functioning of endorphins) 2. Antiopiates- Chemicals like neuropeptide FF, orphanin FQ/nociceptin, and Tyr-W- ...
... 1. Receptor Downregulation- Opioid receptors in the body are actively reduced due to overexposure to opioids. This can also have an effect on endogenous opioid peptide function (i.e. regular functioning of endorphins) 2. Antiopiates- Chemicals like neuropeptide FF, orphanin FQ/nociceptin, and Tyr-W- ...
Treatments for Diabetes Mellitus
... PPAR alpha and PPAR gamma • PPAR alphas are lipoprotein regulators expressed in catabolic tissues such as the liver, kidney, heart and skeletal muscles • PPAR gamma is primarily expressed in adipose tissue, however, it is occasionally active in skeletal muscle, kidney, and intestine • PPAR gamma’s ...
... PPAR alpha and PPAR gamma • PPAR alphas are lipoprotein regulators expressed in catabolic tissues such as the liver, kidney, heart and skeletal muscles • PPAR gamma is primarily expressed in adipose tissue, however, it is occasionally active in skeletal muscle, kidney, and intestine • PPAR gamma’s ...
the PDF file to learn more
... GPCRs have proven to be a valuable target family for drug discovery and development with more than 30% of marketed drugs acting through this receptor superfamily. However, numerous GPCR members remain challenging with no selective and druggable ligands being successfully developed. For these difficu ...
... GPCRs have proven to be a valuable target family for drug discovery and development with more than 30% of marketed drugs acting through this receptor superfamily. However, numerous GPCR members remain challenging with no selective and druggable ligands being successfully developed. For these difficu ...
Identification of novel natural compound inhibitors for human
... lesions or diseases, with symptoms including hyperalgesia or allodynia (Kidd, 2001; Baron et al., 2010). Even painkillers, like opioids and nonsteroidal anti-inflammatory drugs (NSAID) which are generally very efficient, are only partially effective; even worse, studies revealed that prolonged expos ...
... lesions or diseases, with symptoms including hyperalgesia or allodynia (Kidd, 2001; Baron et al., 2010). Even painkillers, like opioids and nonsteroidal anti-inflammatory drugs (NSAID) which are generally very efficient, are only partially effective; even worse, studies revealed that prolonged expos ...
Addiction - ISpatula
... than it is made out to be, and certainly less harmful than legal drugs like tobacco and alcohol. It is impossible die from marijuana, unlike most other illegal drugs and many legal ones. Most of the supposed scientific evidence for brain damage, infertility, etc. have been disproven. ...
... than it is made out to be, and certainly less harmful than legal drugs like tobacco and alcohol. It is impossible die from marijuana, unlike most other illegal drugs and many legal ones. Most of the supposed scientific evidence for brain damage, infertility, etc. have been disproven. ...
Chapter 14 Sedative
... alpha subunits. Benzodiazepine drugs can binds to these sites,but they don’t substitute for GABA. They appear to enhance GABA’effects without directly activating GABA receptors or opening the associated chloride channels. The enhancement in chloride ion conductance induced by the interaction of benz ...
... alpha subunits. Benzodiazepine drugs can binds to these sites,but they don’t substitute for GABA. They appear to enhance GABA’effects without directly activating GABA receptors or opening the associated chloride channels. The enhancement in chloride ion conductance induced by the interaction of benz ...
Docking and Drug Design
... What is a drug? • Ligands that bind to a specific protein • Either increase its activity (an agonist) or decrease/block its activity (an antagonist) • Many problems… solubility, stability, selectivity • Most drugs are not very selective… side effects • Rational drug design… exploit structure of ...
... What is a drug? • Ligands that bind to a specific protein • Either increase its activity (an agonist) or decrease/block its activity (an antagonist) • Many problems… solubility, stability, selectivity • Most drugs are not very selective… side effects • Rational drug design… exploit structure of ...
The Nemertine Toxin Anabaseine and Its Derivative DMXBA (GTS-21): Chemical and Pharmacological Properties
... pHs like anabaseine. In principle, these compounds can adopt two possible conformations with respect to the vinyl portion of the arylidene ring, namely E- or Z. By NMR we have shown that only the E form occurs in aqueous solution when the synthetic DMXBA dihydrochloride is dissolved in water [97]. O ...
... pHs like anabaseine. In principle, these compounds can adopt two possible conformations with respect to the vinyl portion of the arylidene ring, namely E- or Z. By NMR we have shown that only the E form occurs in aqueous solution when the synthetic DMXBA dihydrochloride is dissolved in water [97]. O ...
Treatment of Peptic Ulcer Disease
... Curing the infection not only heals peptic ulcer but also prevents ulcer relapse. [4] [5] Although hospitalizations for uncomplicated peptic ulcers in western countries had begun to decline by the 1950s, there was an increase in admissions for ulcer hemorrhage and perforation among the elderly. ...
... Curing the infection not only heals peptic ulcer but also prevents ulcer relapse. [4] [5] Although hospitalizations for uncomplicated peptic ulcers in western countries had begun to decline by the 1950s, there was an increase in admissions for ulcer hemorrhage and perforation among the elderly. ...
PowerPoint 演示文稿
... drug does the body. That is original action between the drug and the cells of the body. The action of the drug does the body. That is original action between the drug and the cells of the body. ...
... drug does the body. That is original action between the drug and the cells of the body. The action of the drug does the body. That is original action between the drug and the cells of the body. ...
Name ______________________________ CH 204, Fall 2014 Assignment 8 – Opioids
... has overdosed on acetaminophen. ...
... has overdosed on acetaminophen. ...
Release of norepinephrine: Removal of norepinephrine:
... For β receptors, the rank order of potency is isoproterenol > epinephrine > norepinephrine. The β adrenoceptors can be subdivided into three major subgroups, β 1, β 2, and β 3, based on their affinities for adrenergic agonists and antagonists. β 1 Receptors have approximately equal affinities for e ...
... For β receptors, the rank order of potency is isoproterenol > epinephrine > norepinephrine. The β adrenoceptors can be subdivided into three major subgroups, β 1, β 2, and β 3, based on their affinities for adrenergic agonists and antagonists. β 1 Receptors have approximately equal affinities for e ...
Specific NT systems
... death of dopaminergic cells in Parkinson’s disease amphetamine, cocaine (agonist) anti-psychotic drugs (antagonists) metylphenidate (ritalin) ...
... death of dopaminergic cells in Parkinson’s disease amphetamine, cocaine (agonist) anti-psychotic drugs (antagonists) metylphenidate (ritalin) ...
Chemotherapy-Induced Nausea and Vomiting
... and vomiting.43,44 Several lines of evidence suggest that antagonism of 5-HT binding to 5-HT3 receptors on vagal afferents constitutes the predominant mechanism by which the 5-HT3 antagonists exert their antiemetic effect.39,45 During the past two decades, multiple studies have suggested that substa ...
... and vomiting.43,44 Several lines of evidence suggest that antagonism of 5-HT binding to 5-HT3 receptors on vagal afferents constitutes the predominant mechanism by which the 5-HT3 antagonists exert their antiemetic effect.39,45 During the past two decades, multiple studies have suggested that substa ...
Successful Drug Discovery, Volume 1 Brochure
... the last decade, from established drugs to recently introduced drugs of all kinds: small–molecule–, peptide–, and protein–based drugs. The role of serendipity is analyzed in some very successful drugs where the research targets of the lead molecule and the drug are different. Phenotypic and target–b ...
... the last decade, from established drugs to recently introduced drugs of all kinds: small–molecule–, peptide–, and protein–based drugs. The role of serendipity is analyzed in some very successful drugs where the research targets of the lead molecule and the drug are different. Phenotypic and target–b ...
563 kB - recent advances remifentanil mgmc
... • Bretazanil and imidazanil are newer benzodiazepine agonists with less tolerance ...
... • Bretazanil and imidazanil are newer benzodiazepine agonists with less tolerance ...
Twisting arms to angiotensin receptor blockers/antagonists: the turn
... report on such a sensitive endpoint may have on physicians currently prescribing ARBs, we felt that it is important to critically discuss some aspects of this report and, most of all, examine the biological data that support the assertion that ARBs may increase cancer risk. With all due respect to a ...
... report on such a sensitive endpoint may have on physicians currently prescribing ARBs, we felt that it is important to critically discuss some aspects of this report and, most of all, examine the biological data that support the assertion that ARBs may increase cancer risk. With all due respect to a ...