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... Is Cannabis for everyone? NO! • some people cannot tolerate it or it does not work for them • There is a risk for psychological addiction • Minimal physical dependence (withdrawal is mainly irritability, depression) • Tolerance may develop in heavy, long term users - may need higher doses • Patient ...
... Is Cannabis for everyone? NO! • some people cannot tolerate it or it does not work for them • There is a risk for psychological addiction • Minimal physical dependence (withdrawal is mainly irritability, depression) • Tolerance may develop in heavy, long term users - may need higher doses • Patient ...
Reversible and regionally selective downregulation of brain
... changes in CB1 receptor density. Our findings are unaffected by group differences in peripheral distribution and metabolism of the radioligand, because the outcome measure VT corrects for these effects. These findings confirm that chronic cannabis exposure reversibly downregulates CB1 receptors in h ...
... changes in CB1 receptor density. Our findings are unaffected by group differences in peripheral distribution and metabolism of the radioligand, because the outcome measure VT corrects for these effects. These findings confirm that chronic cannabis exposure reversibly downregulates CB1 receptors in h ...
Lecture 4, 5- drugs used in bronchial asthma & COPD
... Long acting bronchodilators (12 hours) have high lipid solubility (creates depot effect) are given by inhalation are not used to relieve acute episodes of asthma used for nocturnal asthma (long acting relievers). combined with inhaled corticosteroids to control asthma (decreases the numb ...
... Long acting bronchodilators (12 hours) have high lipid solubility (creates depot effect) are given by inhalation are not used to relieve acute episodes of asthma used for nocturnal asthma (long acting relievers). combined with inhaled corticosteroids to control asthma (decreases the numb ...
Pharmacology of anaesthetics
... Mechanism of action – via receptors Used for induction (sevoflurane) And maintenance of anaesthesia Commonly used : Sevoflurane, Isoflurane Dose dependent CV and respiratory depression All, but N2O trigger malignant hyperthermia ...
... Mechanism of action – via receptors Used for induction (sevoflurane) And maintenance of anaesthesia Commonly used : Sevoflurane, Isoflurane Dose dependent CV and respiratory depression All, but N2O trigger malignant hyperthermia ...
antihypertensive drugs
... - competitive antagonists of Angiotensin II Type I receptors - Type I receptors mediate: aldosterone, ADH, TPR, sympathetic NS - Type II receptors mediate: vasodilation (TPR), NO - use increasing, no generic, used if cannot tolerate ACEI - actions similar to ACEI but not associated with dry c ...
... - competitive antagonists of Angiotensin II Type I receptors - Type I receptors mediate: aldosterone, ADH, TPR, sympathetic NS - Type II receptors mediate: vasodilation (TPR), NO - use increasing, no generic, used if cannot tolerate ACEI - actions similar to ACEI but not associated with dry c ...
Drugs for the Treatment of Heroin Addiction
... Longer-lasting than methadone, not as long as LAAM ...
... Longer-lasting than methadone, not as long as LAAM ...
GLASS: a comprehensive database for
... Results: We have developed a new database, GLASS, which aims to provide a comprehensive, manually curated resource for experimentally validated GPCR-ligand associations. A new textmining algorithm was proposed to collect GPCR-ligand interactions from the biomedical literature, which is then crossche ...
... Results: We have developed a new database, GLASS, which aims to provide a comprehensive, manually curated resource for experimentally validated GPCR-ligand associations. A new textmining algorithm was proposed to collect GPCR-ligand interactions from the biomedical literature, which is then crossche ...
Dr. Ali Famous Shelf Review
... c. bethanechol: ileus, urinary retention d. pilocarpine 2. anticholinesterases a. edrophonium: diagnostic tool for MG, shorter action of duration which is important for us b. neostigmine c. physostigmine: goes into BBB d. organophosphorous compounds: parathion, malathion 3. ganglion blockers a. hexa ...
... c. bethanechol: ileus, urinary retention d. pilocarpine 2. anticholinesterases a. edrophonium: diagnostic tool for MG, shorter action of duration which is important for us b. neostigmine c. physostigmine: goes into BBB d. organophosphorous compounds: parathion, malathion 3. ganglion blockers a. hexa ...
1. An introduction to drugs, their action and discovery
... Stability after administration and shelf-life Three strategies are commonly used for improving a drug’s in situ stability: 1. Modifying its structure; prepare a more stable analogue with the same pharmacological activity 2. Administering the drug as a more stable prodrug (A biologically inactive ...
... Stability after administration and shelf-life Three strategies are commonly used for improving a drug’s in situ stability: 1. Modifying its structure; prepare a more stable analogue with the same pharmacological activity 2. Administering the drug as a more stable prodrug (A biologically inactive ...
adrenoceptor agonist sympathomimetics
... By the end of this lecture, students should be able to • to describe different classes of anti-platelet drugs depending on their target of action. • To understand pharmacokinetics, pharmacological effects, clinical applications and side effects of anti-platelet drugs. ...
... By the end of this lecture, students should be able to • to describe different classes of anti-platelet drugs depending on their target of action. • To understand pharmacokinetics, pharmacological effects, clinical applications and side effects of anti-platelet drugs. ...
INSUFICIÊNCIA CARDÍACA
... “The situation when the heart is incapable of maintaining a cardiac output adequate to accommodate metabolic requirements and the ...
... “The situation when the heart is incapable of maintaining a cardiac output adequate to accommodate metabolic requirements and the ...
Biomedical Product Development
... • Usually a subcellular component (enzyme, receptor, etc.) removed from a living system and studied in vitro • ACTIVES: agents that stimulate or ...
... • Usually a subcellular component (enzyme, receptor, etc.) removed from a living system and studied in vitro • ACTIVES: agents that stimulate or ...
Extra slides: substance abuse
... 4. There is a persistent desire or unsuccessful efforts to cut down or control substance use 5. A great deal of time is spent in activities necessary to obtain the substance, use the substance, or recover from its effects ...
... 4. There is a persistent desire or unsuccessful efforts to cut down or control substance use 5. A great deal of time is spent in activities necessary to obtain the substance, use the substance, or recover from its effects ...
Effects of Cannabinoids on Synaptic Transmission in the Frog
... been shown to be related to the inhibition of transmitter release in different synapses of the central nervous system and in smooth muscle (Ishac et al., 1996; Engler et al., 2006). The mechanism by which cannabinoids affect transmitter release is thought to work through the activation of potassium ...
... been shown to be related to the inhibition of transmitter release in different synapses of the central nervous system and in smooth muscle (Ishac et al., 1996; Engler et al., 2006). The mechanism by which cannabinoids affect transmitter release is thought to work through the activation of potassium ...
Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5
... When administered to mice by the intravenous (iv) route, 1 exhibited a high plasma clearance of 115 (mL/min)/kg (Table 3), above mouse liver blood flow (approximately 90 (mL/min)/kg), and consequently 1 had a relatively short plasma half-life (<1 h). We postulated that this was predominantly due to ...
... When administered to mice by the intravenous (iv) route, 1 exhibited a high plasma clearance of 115 (mL/min)/kg (Table 3), above mouse liver blood flow (approximately 90 (mL/min)/kg), and consequently 1 had a relatively short plasma half-life (<1 h). We postulated that this was predominantly due to ...
Treatment of opioid-induced gut dysfunction
... remained an enigma to scientists until it was realised that both opioid peptides and opioid receptors are expressed in the digestive tract; therefore, it is important to briefly consider the endogenous opioid system in the gut and its physiological and pathophysiological implications (Figure 1) to u ...
... remained an enigma to scientists until it was realised that both opioid peptides and opioid receptors are expressed in the digestive tract; therefore, it is important to briefly consider the endogenous opioid system in the gut and its physiological and pathophysiological implications (Figure 1) to u ...
PPT, 6.99MB
... • Dipyridamole inhibits platelet aggregation by several mechanisms, including inhibition of phosphodiesterase, block of adenosine uptake into red cells and inhibition of TXA2 synthesis. • studies shows that a modified-release form of dipyridamole reduced the risk of stroke and death in patients with ...
... • Dipyridamole inhibits platelet aggregation by several mechanisms, including inhibition of phosphodiesterase, block of adenosine uptake into red cells and inhibition of TXA2 synthesis. • studies shows that a modified-release form of dipyridamole reduced the risk of stroke and death in patients with ...
April 2017
... Suboxone® is a Schedule III Controlled Substance containing the long-acting partial opioid agonist buprenorphine in combination with the opioid antagonist naloxone. Suboxone® is FDA-approved for maintenance treatment of opioid dependence as part of a complete treatment plan that incorporates counsel ...
... Suboxone® is a Schedule III Controlled Substance containing the long-acting partial opioid agonist buprenorphine in combination with the opioid antagonist naloxone. Suboxone® is FDA-approved for maintenance treatment of opioid dependence as part of a complete treatment plan that incorporates counsel ...
9.98 Neuropharmacology January
... There is a connection between the NE system and anxiety In general, the NE system is activated by alerting situations Some of the effects of anxiolytic drugs can be explained with the modulation of LC firing LC firing is activated by the corticotropin-releasing factor and it is inhibited by GABA and ...
... There is a connection between the NE system and anxiety In general, the NE system is activated by alerting situations Some of the effects of anxiolytic drugs can be explained with the modulation of LC firing LC firing is activated by the corticotropin-releasing factor and it is inhibited by GABA and ...
Pharmacology
... transforming growth factor –β (TGFβ), and many other topic hormones. These receptors are polypeptides consisting of an extracellular hormone binding domain and a cytoplasmic enzyme domain, which may be a protein tyrosine kinase, a serine kinase, or a guanylyl cyclase. ...
... transforming growth factor –β (TGFβ), and many other topic hormones. These receptors are polypeptides consisting of an extracellular hormone binding domain and a cytoplasmic enzyme domain, which may be a protein tyrosine kinase, a serine kinase, or a guanylyl cyclase. ...
Functional Characterization of GABAA Receptors in Neonatal
... techniques are clearly informative, it is accepted that conclusions derived using them may be limited. For instance, mRNA levels do not necessarily correlate with expression of functional receptors (Saha et al. 2001). Moreover, results from immunohistochemical studies may be impacted by tissue prepa ...
... techniques are clearly informative, it is accepted that conclusions derived using them may be limited. For instance, mRNA levels do not necessarily correlate with expression of functional receptors (Saha et al. 2001). Moreover, results from immunohistochemical studies may be impacted by tissue prepa ...