Role of the Androgen Receptor in Human Breast Cancer
... and progesterone receptor (PR) in human breast tumors, its role in breast cancer is poorly understood. Specific growth stimulatory and inhibitory actions of androgens have been described in human breast cancer cell lines. The mechanisms by which androgens exert these contrasting growth effects are u ...
... and progesterone receptor (PR) in human breast tumors, its role in breast cancer is poorly understood. Specific growth stimulatory and inhibitory actions of androgens have been described in human breast cancer cell lines. The mechanisms by which androgens exert these contrasting growth effects are u ...
Pharmacological
... Ipratropium: used by some patients w/ COPD Glycopyrrolate: useful during surgery to decrease secretions Tolterodine: used chronically by some patients w/ incontinence due to “overactive bladder” Diphenhydramine: used in OTC sleep-aid preparations, as an anti-histamine, tx of motion sickness, and ant ...
... Ipratropium: used by some patients w/ COPD Glycopyrrolate: useful during surgery to decrease secretions Tolterodine: used chronically by some patients w/ incontinence due to “overactive bladder” Diphenhydramine: used in OTC sleep-aid preparations, as an anti-histamine, tx of motion sickness, and ant ...
Opioid Tolerance and Dependence in Infants and Children
... Addiction represents a complex behavior characterized by the compulsive use of a drug. The use of opioids for analgesia or sedation does not result in psychological dependence or addiction. Epidemiology: There are several clinical reports that indicate that the incidence of iatrogenic induced opioid ...
... Addiction represents a complex behavior characterized by the compulsive use of a drug. The use of opioids for analgesia or sedation does not result in psychological dependence or addiction. Epidemiology: There are several clinical reports that indicate that the incidence of iatrogenic induced opioid ...
Center for Neuropharmacology and Neuroscience
... Enclosed are four copies of our revised manuscript (MS96MG-095) entitled, "Ibogaine And The Dopaminergic Response To Nicotine," authored by S.D. Glick, G.L. Mann, C.R. Deibel and myself which we would like to resubmit for publication in Psychopharmacolog1- We do not think that it would be appropriat ...
... Enclosed are four copies of our revised manuscript (MS96MG-095) entitled, "Ibogaine And The Dopaminergic Response To Nicotine," authored by S.D. Glick, G.L. Mann, C.R. Deibel and myself which we would like to resubmit for publication in Psychopharmacolog1- We do not think that it would be appropriat ...
Appendix-A - Zacks Small Cap Institutional Research
... Avandia. LGND will receive low double-digit royalties on LY818. Peak LY818 sales could reach near a billion dollars in Type II diabetes. Wyeth: LGND and WYE are co-developing a SERM (selective estrogen receptor modulator) for osteoporosis called bazedoxifene. The drug is in Phase III clinical tria ...
... Avandia. LGND will receive low double-digit royalties on LY818. Peak LY818 sales could reach near a billion dollars in Type II diabetes. Wyeth: LGND and WYE are co-developing a SERM (selective estrogen receptor modulator) for osteoporosis called bazedoxifene. The drug is in Phase III clinical tria ...
Welcome to Week 6 Chapter 10 - Lead Discovery 10.1 In Vitro
... put through a battery of tests ‐ the filtering process that we discussed in sections 10.3, 10.4, and 10.5 ‐ to make sure that only the most promising compounds are advanced as leads. Once a lead, a molecule will require more and more resources from the pharmaceutical company. One aspect of lead ...
... put through a battery of tests ‐ the filtering process that we discussed in sections 10.3, 10.4, and 10.5 ‐ to make sure that only the most promising compounds are advanced as leads. Once a lead, a molecule will require more and more resources from the pharmaceutical company. One aspect of lead ...
STUDY OF THE NEUROMODULATORY EFFECTS OF DOPAMINE
... result of chronic cocaine self-administration. In drug naïve rats we observed that DA dosedependently decreased GABAA-inhibitory post-synaptic currents (IPSC) through the actions of pre-synaptic D2 receptors. However in rats maintaining cocaine self-administration, DA (1!M) increased the amplitude o ...
... result of chronic cocaine self-administration. In drug naïve rats we observed that DA dosedependently decreased GABAA-inhibitory post-synaptic currents (IPSC) through the actions of pre-synaptic D2 receptors. However in rats maintaining cocaine self-administration, DA (1!M) increased the amplitude o ...
Dr. Glick PowerPoint presentation
... Enclosed are four copies of our revised manuscript (MS96MG-095) entitled, "Ibogaine And The Dopaminergic Response To Nicotine," authored by S.D. Glick, G.L. Mann, C.R. Deibel and myself which we would like to resubmit for publication in Psychopharmacolog1- We do not think that it would be appropriat ...
... Enclosed are four copies of our revised manuscript (MS96MG-095) entitled, "Ibogaine And The Dopaminergic Response To Nicotine," authored by S.D. Glick, G.L. Mann, C.R. Deibel and myself which we would like to resubmit for publication in Psychopharmacolog1- We do not think that it would be appropriat ...
Muscle Relaxants
... released at the neuromuscular junction to bind with the ACh receptors on the postsynaptic membrane of the motor endplate They therefore block the action of ACh and prevent depolarisation. ...
... released at the neuromuscular junction to bind with the ACh receptors on the postsynaptic membrane of the motor endplate They therefore block the action of ACh and prevent depolarisation. ...
Inhibition of platelet aggregability by losartan in essential hypertension
... because it occurs at doses 1,000-fold higher than those required for binding to vascular AT1 receptors 8, 9, 13. Although the argument has been posed that chronic therapy with losartan (80 to 120 mg oral dose) may expose platelets to circulating drug concentrations amounting to 1 µmol/L 8, 13 this s ...
... because it occurs at doses 1,000-fold higher than those required for binding to vascular AT1 receptors 8, 9, 13. Although the argument has been posed that chronic therapy with losartan (80 to 120 mg oral dose) may expose platelets to circulating drug concentrations amounting to 1 µmol/L 8, 13 this s ...
Slide 1
... Guideline for the Prevention of Acute Nausea and Vomiting Following Chemotherapy of Moderate Emetic Risk (MEC): Example - Women receiving a combination of anthracycline + cyclophosphamide represent a situation with a particularly great risk of vomiting and nausea. To prevent acute vomiting and naus ...
... Guideline for the Prevention of Acute Nausea and Vomiting Following Chemotherapy of Moderate Emetic Risk (MEC): Example - Women receiving a combination of anthracycline + cyclophosphamide represent a situation with a particularly great risk of vomiting and nausea. To prevent acute vomiting and naus ...
drugs acting at the neuromuscular junction
... Most of the agents in this category would be classified as non-depolarizing though some consider mivacurium to be longer acting drug similar to suxamethonium. 3. Gallamine and other chemical classes: Gallamine is a trisquaternary ether with three ethonium heads attached to a phenyl ring through an e ...
... Most of the agents in this category would be classified as non-depolarizing though some consider mivacurium to be longer acting drug similar to suxamethonium. 3. Gallamine and other chemical classes: Gallamine is a trisquaternary ether with three ethonium heads attached to a phenyl ring through an e ...
Parazoanthoxanthin A blocks Torpedo nicotinic acetylcholine
... [22,23], but at higher concentrations than those used in our experiments. Further experiments using different agonist concentrations and clamping voltages are needed to reveal all the possible mechanisms of the action of ParaA on nAChR. Conflict of interest statement The authors declare that there is ...
... [22,23], but at higher concentrations than those used in our experiments. Further experiments using different agonist concentrations and clamping voltages are needed to reveal all the possible mechanisms of the action of ParaA on nAChR. Conflict of interest statement The authors declare that there is ...
Heart Failure
... To investigate potential underlying causes of hypertension when initial evaluation suggests this possibility. To evaluate therapeutic problems or failures. Special circumstances: Unusually variable blood pressure, possible white coat hypertension, pregnancy. ...
... To investigate potential underlying causes of hypertension when initial evaluation suggests this possibility. To evaluate therapeutic problems or failures. Special circumstances: Unusually variable blood pressure, possible white coat hypertension, pregnancy. ...
Acromegaly: A New Therapy
... used in those patients not cured by surgery. Radiation can be given either as a series of treatments over several weeks or as a single treatment (stereotactic radiosurgery). The major disadvantage of radiation therapy is the slow onset of action. It often takes many years to reach maximal levels of ...
... used in those patients not cured by surgery. Radiation can be given either as a series of treatments over several weeks or as a single treatment (stereotactic radiosurgery). The major disadvantage of radiation therapy is the slow onset of action. It often takes many years to reach maximal levels of ...
et al. - Deep learning for chemoinformatics
... • Identified a selective submicromolar agonist tool compound ...
... • Identified a selective submicromolar agonist tool compound ...
Psychopharmacology
... • Dronabinol is also approved for use as an appetite stimulant in AIDS patients suffering from anorexiacachexia (wasting syndrome). – THC also stimulates food intake in experimental animals • For high-fat or sweet high-fat diets • Not for lab chow • This effect is blocked by rimonabant ...
... • Dronabinol is also approved for use as an appetite stimulant in AIDS patients suffering from anorexiacachexia (wasting syndrome). – THC also stimulates food intake in experimental animals • For high-fat or sweet high-fat diets • Not for lab chow • This effect is blocked by rimonabant ...
313-1A (1)
... It is an orally active non-peptidic hypotensive agent acting through its high affinity for Angiotensin II receptor sites of the smooth muscles, kidney and adrenal glands. It does not inhibit ACE, therefore avoiding the serious side effects of ACE inhibitors. ...
... It is an orally active non-peptidic hypotensive agent acting through its high affinity for Angiotensin II receptor sites of the smooth muscles, kidney and adrenal glands. It does not inhibit ACE, therefore avoiding the serious side effects of ACE inhibitors. ...
Fragment library screening against the Hepatitis C drug target
... procedures enabled the identification of sixteen wellbehaved fragments with affinities in the low millimolar range. Follow up experiments have demonstrated that six of these fragments compete with filibuvir for binding, indicating that they may be allosteric site binders. They are now the focus of ...
... procedures enabled the identification of sixteen wellbehaved fragments with affinities in the low millimolar range. Follow up experiments have demonstrated that six of these fragments compete with filibuvir for binding, indicating that they may be allosteric site binders. They are now the focus of ...
In vivo imaging of dopamine and serotonin release Udo de
... treatment of a variety of neurological and psychiatric disorders such as schizophrenia, Parkinson’s disease, depression and addiction (Kapur and Mamo 2003; Leenders 2002; Naranjo et al. 2001; Volkow et al. 2002a). The involvement of dopamine (DA) in these disorders may be related to its function in ...
... treatment of a variety of neurological and psychiatric disorders such as schizophrenia, Parkinson’s disease, depression and addiction (Kapur and Mamo 2003; Leenders 2002; Naranjo et al. 2001; Volkow et al. 2002a). The involvement of dopamine (DA) in these disorders may be related to its function in ...
Structure-based drug design strategies in medicinal
... but not exhibiting good oral absorption and stability (e.g., CGP 38560, IC50 = 0.7 nM). To overcome these hindrances, hydroxyethylene transition-state mimetic inhibitors of lower molecular weight were designed to explore the shape and chemical properties of the large hydrophobic S1/S3 binding cavity ...
... but not exhibiting good oral absorption and stability (e.g., CGP 38560, IC50 = 0.7 nM). To overcome these hindrances, hydroxyethylene transition-state mimetic inhibitors of lower molecular weight were designed to explore the shape and chemical properties of the large hydrophobic S1/S3 binding cavity ...
Adverse reactions
... • Five dopaminergic systems or pathways are important for understanding schizophrenia and the mechanism of action of antipsychotic drugs: 1) Mesolimbic-mesocortical pathway: the one most closely related to behavior and psychosis 2) Nigrostriatal pathway: it is involved in the coordination of volunta ...
... • Five dopaminergic systems or pathways are important for understanding schizophrenia and the mechanism of action of antipsychotic drugs: 1) Mesolimbic-mesocortical pathway: the one most closely related to behavior and psychosis 2) Nigrostriatal pathway: it is involved in the coordination of volunta ...
