Pulmonary Hypertension
... pulmonary hypertension. • Recognize common drug-drug and drug-herbal interactions with pulmonary hypertension management medications and what to expect. • Identify the most common adverse effects seen with medications used to manage pulmonary hypertension. ...
... pulmonary hypertension. • Recognize common drug-drug and drug-herbal interactions with pulmonary hypertension management medications and what to expect. • Identify the most common adverse effects seen with medications used to manage pulmonary hypertension. ...
Potassium Sparing Diuretics
... Synthetic steroids acts as competitive antagonist of adlosterone with slow onset of action. ...
... Synthetic steroids acts as competitive antagonist of adlosterone with slow onset of action. ...
Ca 2+
... • Bind to specific sites on the alpha1 subunit of the L-type Ca2+ channel • Reduce the probability of channel opening rather then calcium current flow through an open channel • Tissue selectivity is one of the most beneficial properties of Ca2+ antagonists • In general, skeletal muscle, bronchial, t ...
... • Bind to specific sites on the alpha1 subunit of the L-type Ca2+ channel • Reduce the probability of channel opening rather then calcium current flow through an open channel • Tissue selectivity is one of the most beneficial properties of Ca2+ antagonists • In general, skeletal muscle, bronchial, t ...
16 Antidepressants
... • Side effects can include anxiety, restlessness, tremor, insomnia, seizures • Also marketed as a smoking cessation (Zyban®) ...
... • Side effects can include anxiety, restlessness, tremor, insomnia, seizures • Also marketed as a smoking cessation (Zyban®) ...
Anti Epileptic Drugs
... • Rash especially if valproate is also given, if starting dose is high or if dose escalation is rapid (Rash may disappear despite continued ...
... • Rash especially if valproate is also given, if starting dose is high or if dose escalation is rapid (Rash may disappear despite continued ...
NMR to characterise protein-ligand interaction
... • protein-ligand structures yield binding modes - very valuable to understand ligand SAR (structure-activity relationship) • crystallography is the preferred option • a soakable system can yield structures in high throughput (and even be used for screening) Develop crystal system ...
... • protein-ligand structures yield binding modes - very valuable to understand ligand SAR (structure-activity relationship) • crystallography is the preferred option • a soakable system can yield structures in high throughput (and even be used for screening) Develop crystal system ...
56 Management of Hypertension – Role of Combination Therapy
... This combination can be suggested for the treatment of hypertensive patients with nephropathy, CHD or established atherosclerosis. The combination displays pronounced antihypertensive activity. Ca-antagonists are known to have anti-ischemic activity in CHD. ACE-inhibitors are proved to be renoprotec ...
... This combination can be suggested for the treatment of hypertensive patients with nephropathy, CHD or established atherosclerosis. The combination displays pronounced antihypertensive activity. Ca-antagonists are known to have anti-ischemic activity in CHD. ACE-inhibitors are proved to be renoprotec ...
1. Immediate 2. Delayed 3. Cumulative
... The time course of digoxin concentration in plasma (Cp) can be used to predict the average concentration in all the other tissues of the body (Ct). Note that Ct is not specific for any particular organ or tissue so it is not likely to reflect the distribution and equilibration at the site of action. ...
... The time course of digoxin concentration in plasma (Cp) can be used to predict the average concentration in all the other tissues of the body (Ct). Note that Ct is not specific for any particular organ or tissue so it is not likely to reflect the distribution and equilibration at the site of action. ...
Aprepitant Emend™ — Merck Frosst Canada Ltd.
... sensitive to whether one or four days of a 5-HT3 antagonist was used, ranging from $21,000 to $101,000 per quality-adjusted life year (QALY). Given this uncertainty, the Committee felt that aprepitant should be reserved for use in patients who have not responded to a combination of a 5-HT3 antagonis ...
... sensitive to whether one or four days of a 5-HT3 antagonist was used, ranging from $21,000 to $101,000 per quality-adjusted life year (QALY). Given this uncertainty, the Committee felt that aprepitant should be reserved for use in patients who have not responded to a combination of a 5-HT3 antagonis ...
Molecular imprinting - Utrecht University Repository
... matrix, or a combination of both. There is an ongoing interest to identify additional tools to modify the release profile of a drug from a polymer matrix, and molecular imprinting has been suggested as one of those tools. Two comprehensive review papers have been recently published about the use of ...
... matrix, or a combination of both. There is an ongoing interest to identify additional tools to modify the release profile of a drug from a polymer matrix, and molecular imprinting has been suggested as one of those tools. Two comprehensive review papers have been recently published about the use of ...
Benzodiazepines
... • Benzodiazepines increase the affinity of the receptor for GABA, and thus increase Cl- conductance and hyperpolarizing current ...
... • Benzodiazepines increase the affinity of the receptor for GABA, and thus increase Cl- conductance and hyperpolarizing current ...
(A CNS ACTIVE SUBSTANCE) ISOLATED FROM
... depressant effects of ligustroside. Those studies concluded that ligustroside has pharmacodynamic activity as CNS depressant, did not have neuromuscular blocking properties. The primary site of action of its CNS depressant is in the brain, and the mechanism of action may involve the enhancement of G ...
... depressant effects of ligustroside. Those studies concluded that ligustroside has pharmacodynamic activity as CNS depressant, did not have neuromuscular blocking properties. The primary site of action of its CNS depressant is in the brain, and the mechanism of action may involve the enhancement of G ...
JA Jeevendra Martyn
... unit to contract synchronously. The synchronous contraction of the cells in a motor unit is fasciculation and often is vigorous enough to be observed through the skin. Although most adult human muscles have only one neuromuscular junction per cell, an important exception is some of the cells in the ...
... unit to contract synchronously. The synchronous contraction of the cells in a motor unit is fasciculation and often is vigorous enough to be observed through the skin. Although most adult human muscles have only one neuromuscular junction per cell, an important exception is some of the cells in the ...
Anti-anemics
... following myocardial infarction), deep vein thrombosis. – MOA: Inhibits factor Xa, very little effect on factor IIa; aPPT is not used to measure its anticoagulant activity. Binds less to plasma proteins. – Pharmacokinetics: Administration: i.v. and s.c. outpatient basis for DVT patients. Immediate o ...
... following myocardial infarction), deep vein thrombosis. – MOA: Inhibits factor Xa, very little effect on factor IIa; aPPT is not used to measure its anticoagulant activity. Binds less to plasma proteins. – Pharmacokinetics: Administration: i.v. and s.c. outpatient basis for DVT patients. Immediate o ...
Stereochemistry
... The stereochemistry of both the receptor site & the drug molecule helps determine the nature & efficiency of the drug-receptor interaction. Isomers are 2 or more compounds, with the same molecular formula, but have different configurations. They usually differ in chemical, physical or pharmacologica ...
... The stereochemistry of both the receptor site & the drug molecule helps determine the nature & efficiency of the drug-receptor interaction. Isomers are 2 or more compounds, with the same molecular formula, but have different configurations. They usually differ in chemical, physical or pharmacologica ...
Drug Effecting Platelet Function
... transporter, namely the SSRIs and tertiary tricyclics (eg clomipramine & amitriptyline), deplete platelet serotonin thus decreasing one of the signals for intracellular calcium release. In case-control studies they were associated with up to a 10% increase in the rate of gastrointestinal tract (GIT) ...
... transporter, namely the SSRIs and tertiary tricyclics (eg clomipramine & amitriptyline), deplete platelet serotonin thus decreasing one of the signals for intracellular calcium release. In case-control studies they were associated with up to a 10% increase in the rate of gastrointestinal tract (GIT) ...
A systems model of altered consciousness: Integrating natural and
... ABSTRACT: Increasing evidence from neuroimaging and behavioral studies suggests that functional disturbances within cortico-striato-thalamic pathways are critical to psychotic symptom formation in drug-induced and possibly also naturally occurring psychoses. Recent basic and clinical research with p ...
... ABSTRACT: Increasing evidence from neuroimaging and behavioral studies suggests that functional disturbances within cortico-striato-thalamic pathways are critical to psychotic symptom formation in drug-induced and possibly also naturally occurring psychoses. Recent basic and clinical research with p ...
Palliative Care in Winnipeg
... mu () kappa () delta () receptors Now found on: peripheral neurons immune cells inflamed tissue respiratory tissue GI tract ...
... mu () kappa () delta () receptors Now found on: peripheral neurons immune cells inflamed tissue respiratory tissue GI tract ...
Jeopardy
... This typical antipsychotic is available PO, IM, & IV; is commonly used to treat agitated patients in hospitals/ER’s; & can be used to treat Tourette’s syndroms ...
... This typical antipsychotic is available PO, IM, & IV; is commonly used to treat agitated patients in hospitals/ER’s; & can be used to treat Tourette’s syndroms ...
The Translational Research Cycle – Example in Infectious Diseases
... T1 –In vitro laboratory studies to establish the molecular mechanism by which SFN inhibits CYP3A4 gene expression. Based on the initial observation described above, additional laboratory studies were done to evaluate the mechanism(s) by which SFN inhibited CYP3A4 gene expression in human liver cells ...
... T1 –In vitro laboratory studies to establish the molecular mechanism by which SFN inhibits CYP3A4 gene expression. Based on the initial observation described above, additional laboratory studies were done to evaluate the mechanism(s) by which SFN inhibited CYP3A4 gene expression in human liver cells ...
