ANTICONVULSANT ACTIVITY OF METHANOLIC EXTRACT OF MELISSA PARVIFLORA IN
... Epilepsy is a neurological disorder that affects a wide range of people throughout the world. It is the second most common chronic neurological condition seen by neurologists. Incidence of epilepsy in developed countries is approximately 50 per 100, 000 while that of developing country is 100 per 10 ...
... Epilepsy is a neurological disorder that affects a wide range of people throughout the world. It is the second most common chronic neurological condition seen by neurologists. Incidence of epilepsy in developed countries is approximately 50 per 100, 000 while that of developing country is 100 per 10 ...
Morphine HO- Group is needed for activity HO
... superior in alleviating suffering -- and perhaps in a way subjectively closer to that of morphine than hydromorphone, other morphine derivatives, the codeine-based series, or the synthetics. Like metopon, dihydromorphine may be less addictive overall and have better bioavailability after oral admini ...
... superior in alleviating suffering -- and perhaps in a way subjectively closer to that of morphine than hydromorphone, other morphine derivatives, the codeine-based series, or the synthetics. Like metopon, dihydromorphine may be less addictive overall and have better bioavailability after oral admini ...
VIRTUAL SCREENING AND LEAD OPTIMIZATION TO IDENTIFY
... or alleviate symptoms. Drug usually act on either cellular or genetic chemicals in the body, known as targets, which are believed to be associated with disease. Scientists use a variety of techniques to identify and isolate a target and learn more about its functions and how these influence disease. ...
... or alleviate symptoms. Drug usually act on either cellular or genetic chemicals in the body, known as targets, which are believed to be associated with disease. Scientists use a variety of techniques to identify and isolate a target and learn more about its functions and how these influence disease. ...
Morphine
... Fentanyl, which is chemically related to meperidine, has 100-fold the analgesic potency of morphine and is used in anesthesia. The drug is highly lipophilic and has a rapid onset and short duration of action (15 to 30 minutes). It is usually injected IV, epidurally, or intrathecally. Epidural fentan ...
... Fentanyl, which is chemically related to meperidine, has 100-fold the analgesic potency of morphine and is used in anesthesia. The drug is highly lipophilic and has a rapid onset and short duration of action (15 to 30 minutes). It is usually injected IV, epidurally, or intrathecally. Epidural fentan ...
Amino Alkaloids *phenylalkylamine= aromatic ring +alkyl chain +( N
... affecting the cancerous cells and the normal cells ( non-selective toxicity ) , so it's not used despite its very potent anti-mitotic activity . * Colchicine is highly poisonous , it's used in Europe primarily as a suicidal agent. ...
... affecting the cancerous cells and the normal cells ( non-selective toxicity ) , so it's not used despite its very potent anti-mitotic activity . * Colchicine is highly poisonous , it's used in Europe primarily as a suicidal agent. ...
Chemosensory organs
... - chemicals enter taste pores and bind to and stimulate gustatory hairs - the generation of APs in the gustatory cells by the chemical stimulation of the gustatory hairs - the impulse transferred to the sensory neurons which transmits the taste sensation of chocolate ice cream in the cranial nerves ...
... - chemicals enter taste pores and bind to and stimulate gustatory hairs - the generation of APs in the gustatory cells by the chemical stimulation of the gustatory hairs - the impulse transferred to the sensory neurons which transmits the taste sensation of chocolate ice cream in the cranial nerves ...
daniels-broiler-3-2
... narrow therapeutic index cannot be avoided. BCRP Substrates with a Narrow Therapeutic Index (e.g., methotrexate, topotecan, or irinotecan): Increased plasma concentrations of BCRP substrates may result in potential adverse reactions. Monitor for adverse reactions related to the concomitant drug if u ...
... narrow therapeutic index cannot be avoided. BCRP Substrates with a Narrow Therapeutic Index (e.g., methotrexate, topotecan, or irinotecan): Increased plasma concentrations of BCRP substrates may result in potential adverse reactions. Monitor for adverse reactions related to the concomitant drug if u ...
Emory`s CNE Sept 13 WORD
... narrow therapeutic index cannot be avoided. BCRP Substrates with a Narrow Therapeutic Index (e.g., methotrexate, topotecan, or irinotecan): Increased plasma concentrations of BCRP substrates may result in potential adverse reactions. Monitor for adverse reactions related to the concomitant drug if u ...
... narrow therapeutic index cannot be avoided. BCRP Substrates with a Narrow Therapeutic Index (e.g., methotrexate, topotecan, or irinotecan): Increased plasma concentrations of BCRP substrates may result in potential adverse reactions. Monitor for adverse reactions related to the concomitant drug if u ...
Table 4.3: Binding energy between KRAS protein and
... Most other animals are able to produce this compound in their bodies and do not require it in their diets. In cells, it is maintained in its reduced form by reaction with glutathione, which can be catalyzed by protein disulfide isomerase and glutaredoxins. Ascorbic acid is a reducing agent and can r ...
... Most other animals are able to produce this compound in their bodies and do not require it in their diets. In cells, it is maintained in its reduced form by reaction with glutathione, which can be catalyzed by protein disulfide isomerase and glutaredoxins. Ascorbic acid is a reducing agent and can r ...
Zebrafish behavioral profiling links drugs to biological targets and
... Cluster analysis revealed several lines of evidence that molecules with correlated behavioral phenotypes often shared annotated targets or therapeutic indications (Fig. 2, B to F, and figs. S1 to S4). First, drug pairs were more likely to be correlated if the compounds shared at least one annotated ...
... Cluster analysis revealed several lines of evidence that molecules with correlated behavioral phenotypes often shared annotated targets or therapeutic indications (Fig. 2, B to F, and figs. S1 to S4). First, drug pairs were more likely to be correlated if the compounds shared at least one annotated ...
Back_to_basics_pharmacology 1, 2, 3 and 4 Dr Riachi 2012
... If truly allergic to codeine (anaphylaxis), may consider an opioid from a different class such as: – meperidine – fentanyl (Warning: not for narcotic naive or narcotic inexperienced patients) – methadone (not every physician is licensed to prescribe it. Usually reserved for severe pain) – all opioid ...
... If truly allergic to codeine (anaphylaxis), may consider an opioid from a different class such as: – meperidine – fentanyl (Warning: not for narcotic naive or narcotic inexperienced patients) – methadone (not every physician is licensed to prescribe it. Usually reserved for severe pain) – all opioid ...
INSILICO DRUG DESIGN AND MOLECULAR DOCKING STUDIES OF SOME NOVEL
... abnormal over growth of tissues. Benzothiazole is an important class of heterocyclic compound which possess interesting biological activities like anti-tumor, anti-microbial, anti-tubercular, anti-malarial, anti-convulsant, anthelmintic, analgesic and anti-inflammatory activity. The drugs containing ...
... abnormal over growth of tissues. Benzothiazole is an important class of heterocyclic compound which possess interesting biological activities like anti-tumor, anti-microbial, anti-tubercular, anti-malarial, anti-convulsant, anthelmintic, analgesic and anti-inflammatory activity. The drugs containing ...
Curr.Med. Chem._Martínez, A._2015 - digital
... 3.1. Drugs targeting both AChE and NMDA receptors Tacrine was the first drug approved for AD treatment (1993), followed by donepezil (1996), rivastigmine (2000) and galantamine (2001). Each of these are inhibitors of AChE, and produce an increase of acetylcholine neurotrasmission in the synaptic cle ...
... 3.1. Drugs targeting both AChE and NMDA receptors Tacrine was the first drug approved for AD treatment (1993), followed by donepezil (1996), rivastigmine (2000) and galantamine (2001). Each of these are inhibitors of AChE, and produce an increase of acetylcholine neurotrasmission in the synaptic cle ...
Dopamine receptor agonist treatment of Parkinson`s disease
... Parkinson’s disease is a progressive neurodegenerative disorder which affects approximately 1% of individuals over 60 years of age. There has been a growing interest in dopamine agonists as a form of treatment for this disease. The aims of this systematic review and metaanalysis were to establish th ...
... Parkinson’s disease is a progressive neurodegenerative disorder which affects approximately 1% of individuals over 60 years of age. There has been a growing interest in dopamine agonists as a form of treatment for this disease. The aims of this systematic review and metaanalysis were to establish th ...
Role of Calcium-Sensing Receptor (CaSR) in pancreatic islet
... Pancreatic islet G-protein coupled receptors (GPCRs) are critical modulators of α- and β-cells that secrete glucagon and insulin, respectively, and represent an exploitable target for the modulation of glucose homeostasis. The calcium-sensing receptor (CaSR) is a Gq/11-coupled GPCR that is abundantl ...
... Pancreatic islet G-protein coupled receptors (GPCRs) are critical modulators of α- and β-cells that secrete glucagon and insulin, respectively, and represent an exploitable target for the modulation of glucose homeostasis. The calcium-sensing receptor (CaSR) is a Gq/11-coupled GPCR that is abundantl ...
DESIGNING OF POTENTIAL NEW ESTROGEN ANTAGONISTS FOR TREATMENT OF
... It has become a chronic disease nowadays and it can be controlled by estrogen antagonist as estrogen antagonist inhibits the action of estrogen and proliferation of endometrial cell is stopped [6, 13, 18]. The discovery of the first design of Estrogen antagonist drug has inspired a number of continu ...
... It has become a chronic disease nowadays and it can be controlled by estrogen antagonist as estrogen antagonist inhibits the action of estrogen and proliferation of endometrial cell is stopped [6, 13, 18]. The discovery of the first design of Estrogen antagonist drug has inspired a number of continu ...
Opioid-Induced Constipation - American College of Gastroenterology
... of daily living, and a third of patients had missed, decreased, or stopped using opioids in order to make it easier to have a bowel movement (19). ...
... of daily living, and a third of patients had missed, decreased, or stopped using opioids in order to make it easier to have a bowel movement (19). ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008.
... perform docking a specific target protein was chosen for antioxidant compounds. Tyrosine kinase (pdb id: 2HCK) was identified as protein target for current studies. Pdb file 2HCK was obtained from the protein data bank (rscb.org).AutodockVina was used for docking in this study. AutodockVina is the l ...
... perform docking a specific target protein was chosen for antioxidant compounds. Tyrosine kinase (pdb id: 2HCK) was identified as protein target for current studies. Pdb file 2HCK was obtained from the protein data bank (rscb.org).AutodockVina was used for docking in this study. AutodockVina is the l ...
Guideline on the Clinical Investigation of the Pharmacokinetics of
... Mass-balance studies are not useful for determining the excretion pattern of the drug and drug-related material. Excreted proteins are not necessarily recovered in urine or faeces as intact substance, but are instead metabolised and reabsorbed as amino acids and incorporated in the general protein ...
... Mass-balance studies are not useful for determining the excretion pattern of the drug and drug-related material. Excreted proteins are not necessarily recovered in urine or faeces as intact substance, but are instead metabolised and reabsorbed as amino acids and incorporated in the general protein ...
Respiratory drugs-nursing
... a. Non-selective β- agonists - Cause more cardiac stimulation (mediated by a β1 receptor), they should be reserved for special situation. - Epinephrine: very effective, rapidly acting bronchodilator especially preferable for the relief of acute attack of bronchial asthma. - Administered by inhalatio ...
... a. Non-selective β- agonists - Cause more cardiac stimulation (mediated by a β1 receptor), they should be reserved for special situation. - Epinephrine: very effective, rapidly acting bronchodilator especially preferable for the relief of acute attack of bronchial asthma. - Administered by inhalatio ...
Principles of Pharmacology and Toxicology (BIOL3020)
... - neurons regulating breathing patterns also possess µ-opioid - morphine acts like an antagonist, inhibiting signal transmission to the breathing muscles and slowing down the breathing An overdose can cause lungs to collapse and therefore prevent all breathing causing suffocation [2-5] ...
... - neurons regulating breathing patterns also possess µ-opioid - morphine acts like an antagonist, inhibiting signal transmission to the breathing muscles and slowing down the breathing An overdose can cause lungs to collapse and therefore prevent all breathing causing suffocation [2-5] ...
Biomedical aspects of chiral molecules
... and methyl ethyl ether. All these compounds have the molecular formula C3H8O but for all that, these are different individual chemicals with different chemical, physical and biological properties. Organic chemistry knows more types of isomerism (geometrical, positional, etc.) but the focus of this a ...
... and methyl ethyl ether. All these compounds have the molecular formula C3H8O but for all that, these are different individual chemicals with different chemical, physical and biological properties. Organic chemistry knows more types of isomerism (geometrical, positional, etc.) but the focus of this a ...
DISCUSSION 197
... psychedelic activity, the use of subjective-effect measures combined with the administration of pure compounds may alternatively help tease apart the contribution of each of the β-carbolines in the facilitation of DMT absorption per os. The EEG variables provided a quantitative and dose-dependent me ...
... psychedelic activity, the use of subjective-effect measures combined with the administration of pure compounds may alternatively help tease apart the contribution of each of the β-carbolines in the facilitation of DMT absorption per os. The EEG variables provided a quantitative and dose-dependent me ...
Everyone Relax and Breath: Review of Neuromuscular Relaxants
... Mechanism of action Act by blocking ACh receptors Key-in-hole Theory Combine with nicotinic receptors to prevent ACh binding Competitive blockers Prevent depolarization Inhibit muscle contraction ...
... Mechanism of action Act by blocking ACh receptors Key-in-hole Theory Combine with nicotinic receptors to prevent ACh binding Competitive blockers Prevent depolarization Inhibit muscle contraction ...