PocketQuery: protein–protein interaction inhibitor
... points for the design of small-molecule PPI inhibitors (25). PocketQuery provides an interface for exploring high-level features of a PPI interface and rapidly focusing attention on the key clusters of residues that are likely small-molecule inhibitor starting points. There are numerous online resou ...
... points for the design of small-molecule PPI inhibitors (25). PocketQuery provides an interface for exploring high-level features of a PPI interface and rapidly focusing attention on the key clusters of residues that are likely small-molecule inhibitor starting points. There are numerous online resou ...
cAlnOfficial Journalofthe c.AmericanHeart cjlssociation
... traditional pharmacologic models and modern biochemical techniques have documented the existence of distinct dopamine receptor subtypes that mediate these responses. Appreciation of the structure-activity requirements of these receptors has led to the synthesis of drugs that may have a profound infl ...
... traditional pharmacologic models and modern biochemical techniques have documented the existence of distinct dopamine receptor subtypes that mediate these responses. Appreciation of the structure-activity requirements of these receptors has led to the synthesis of drugs that may have a profound infl ...
as a PDF
... and cognitive function probably depends on a number of factors, including localization of receptors in particular brain regions, the signaling pathways activated (or inhibited) by each receptor subtype, and the type of memory being assessed. Overall, however, there is strong evidence that activation ...
... and cognitive function probably depends on a number of factors, including localization of receptors in particular brain regions, the signaling pathways activated (or inhibited) by each receptor subtype, and the type of memory being assessed. Overall, however, there is strong evidence that activation ...
Electronic Structure Based Classification of Neurotransmitters and
... neurological or psychiatric symptoms and result in disease. Examples for disorders associated with the defects in neurotransmission are 1) Alzheimer’s disease caused by reduced synthesis of the neurotransmitter acetylcholine; and 2) Parkinson’s disease caused by the insufficient formation and action ...
... neurological or psychiatric symptoms and result in disease. Examples for disorders associated with the defects in neurotransmission are 1) Alzheimer’s disease caused by reduced synthesis of the neurotransmitter acetylcholine; and 2) Parkinson’s disease caused by the insufficient formation and action ...
2016 EQUINE GASTRO-INTESTINAL MOTILITY
... Disorders of the gastro-intestinal tract are common in horses and are often associated with modifications in the normal intestinal motility pattern. Maintaining sufficient gastro-intestinal activity is essential to facilitate adequate digestion and resorption of nutrients. Disturbed motility pattern ...
... Disorders of the gastro-intestinal tract are common in horses and are often associated with modifications in the normal intestinal motility pattern. Maintaining sufficient gastro-intestinal activity is essential to facilitate adequate digestion and resorption of nutrients. Disturbed motility pattern ...
curriculum vitae - The University of Sydney
... Allsop DJ, McGregor IS, Dunlop A, Saddler C, Rivas G, Copeland J (in press) Changes in cigarette and alcohol use during cannabis abstinence. Drug and Alcohol Dependence. Suraev A, Bowen MT, Ali SO, Hicks C, Ramos L, McGregor IS (in press) Adolescent exposure to oxytocin, but not the selective ox ...
... Allsop DJ, McGregor IS, Dunlop A, Saddler C, Rivas G, Copeland J (in press) Changes in cigarette and alcohol use during cannabis abstinence. Drug and Alcohol Dependence. Suraev A, Bowen MT, Ali SO, Hicks C, Ramos L, McGregor IS (in press) Adolescent exposure to oxytocin, but not the selective ox ...
Molecular Modeling: A Powerful Tool for Drug Design and Molecular
... been used in a variety of bimolecular applications. The technique, when combined with data derived from NMR studies, has been used to derive 3D structures for peptides and small proteins in cases where X-ray crystallography was not practical. Additionally, structural, dynamic and thermodynamic data ...
... been used in a variety of bimolecular applications. The technique, when combined with data derived from NMR studies, has been used to derive 3D structures for peptides and small proteins in cases where X-ray crystallography was not practical. Additionally, structural, dynamic and thermodynamic data ...
PowerPoint-Präsentation
... Anxiolytic substances occupy a prominent post in the ranking of the most utilized drugs by man. However, the anxiolytic drugs have an unfavorable risk/benefit ratio, especially benzodiazepines. Several medicinal plants have been used in traditional folk medicine for their anxiolytic or sedative prop ...
... Anxiolytic substances occupy a prominent post in the ranking of the most utilized drugs by man. However, the anxiolytic drugs have an unfavorable risk/benefit ratio, especially benzodiazepines. Several medicinal plants have been used in traditional folk medicine for their anxiolytic or sedative prop ...
Toward drugs derived from cannabis
... daily) tolerance developed to the side effects, while the sedative-relaxant effect was apparently still significant. This last point needs further clarification. The joint research of the US firms Abbott and SISA has led to the development of nitrogen-containing cannabinoids such as Abbott 40174 and ...
... daily) tolerance developed to the side effects, while the sedative-relaxant effect was apparently still significant. This last point needs further clarification. The joint research of the US firms Abbott and SISA has led to the development of nitrogen-containing cannabinoids such as Abbott 40174 and ...
GPCR ontology: development and application of a G protein
... Motivation: Novel tools need to be developed to help scientists analyze large amounts of available screening data with the goal to identify entry points for the development of novel chemical probes and drugs. As the largest class of drug targets, G protein-coupled receptors (GPCRs) remain of particu ...
... Motivation: Novel tools need to be developed to help scientists analyze large amounts of available screening data with the goal to identify entry points for the development of novel chemical probes and drugs. As the largest class of drug targets, G protein-coupled receptors (GPCRs) remain of particu ...
Redalyc.Neurobiological alterations in alcohol addiction: a review
... have demonstrated that rodents self-administer ethanol directly in the VTA, further supporting the involvement of the reward system in the effects of alcohol (Rodd et al., 2004). Nevertheless, dopaminergic lesion studies with the selective 6-hydroxydopamine neurotoxin consistently show that dopamine ...
... have demonstrated that rodents self-administer ethanol directly in the VTA, further supporting the involvement of the reward system in the effects of alcohol (Rodd et al., 2004). Nevertheless, dopaminergic lesion studies with the selective 6-hydroxydopamine neurotoxin consistently show that dopamine ...
pharm 22 A [4-20
... a. High bleeding risk in patients over 75 years or under 60 kg 3 antagonists of GP IIb-IIIa? What is their common, clinically serious side effect? Why is abciximab unique and what are the clinical implications? a. eptifibatide, abciximab, and tirofiban [don’t FIB about being sick] i. used for ischem ...
... a. High bleeding risk in patients over 75 years or under 60 kg 3 antagonists of GP IIb-IIIa? What is their common, clinically serious side effect? Why is abciximab unique and what are the clinical implications? a. eptifibatide, abciximab, and tirofiban [don’t FIB about being sick] i. used for ischem ...
WHAT`S THE NEXT STEP?
... solved using a mutant variant of the GR LBD different from that used for the Dex and FP complexes, F602Y and C638G, which were introduced to improve expression and purification. These mutations are distant from the ligand binding cavity and do not perturb the overall protein structure. There are no l ...
... solved using a mutant variant of the GR LBD different from that used for the Dex and FP complexes, F602Y and C638G, which were introduced to improve expression and purification. These mutations are distant from the ligand binding cavity and do not perturb the overall protein structure. There are no l ...
Social brains on drugs: tools for neuromodulation
... There are many different types of receptors for each neuromodulator system, and different receptor types can have different effects on neuronal function when activated. For example, dopamine D1 and D2 receptors can have opposing effects on long-term potentiation and neuronal excitability [reviewed b ...
... There are many different types of receptors for each neuromodulator system, and different receptor types can have different effects on neuronal function when activated. For example, dopamine D1 and D2 receptors can have opposing effects on long-term potentiation and neuronal excitability [reviewed b ...
PHARMACOLOGY AND PHARMACEUTICAL INDUSTRY
... patients of Parkinsonism. Indian studies also highlight the utility of receptors for dopamine, Nitric Oxide (NO) on the polymorphonuclear leucocytes in patients of Parkinsonism, migraine, schizophrenia, depression and other CNS disorders. Other Studies: Role of histamine H1 and H2 receptors and enke ...
... patients of Parkinsonism. Indian studies also highlight the utility of receptors for dopamine, Nitric Oxide (NO) on the polymorphonuclear leucocytes in patients of Parkinsonism, migraine, schizophrenia, depression and other CNS disorders. Other Studies: Role of histamine H1 and H2 receptors and enke ...
Chemical Dependency
... Metabolism of alcohol is increased in heavy drinkers Women more easily intoxicated than men. Effects: CNS depression and Peripheral vasodilation Decreased muscle tension, lowered anxiety level, disinhibition, impaired judgment, sedation Toxic effects: stupor, unconsciousness (including bla ...
... Metabolism of alcohol is increased in heavy drinkers Women more easily intoxicated than men. Effects: CNS depression and Peripheral vasodilation Decreased muscle tension, lowered anxiety level, disinhibition, impaired judgment, sedation Toxic effects: stupor, unconsciousness (including bla ...
(rhGH) functional quality characterization by LC/CE-MS and
... Somatropin (i.e. recombinant human growth hormone, rhGH) is a biologic drug, approved to treat growth hormone deficiencies as in pituitary dwarfism. This protein is available on the market as originator drug, as well as biosimilars, but also as SFFCs (spurious/falselylabelled/falsified/counterfeit). ...
... Somatropin (i.e. recombinant human growth hormone, rhGH) is a biologic drug, approved to treat growth hormone deficiencies as in pituitary dwarfism. This protein is available on the market as originator drug, as well as biosimilars, but also as SFFCs (spurious/falselylabelled/falsified/counterfeit). ...
Advances in molecular modeling and docking as a tool for modern
... 2. Ascalaph is general purpose molecular modeling software that performs quantum mechanics calculations for initial molecular model development, molecular mechanics and dynamics simulations in the gas or in condensed phase. It can interact with external molecular modeling packages (MDynaMix, NWChem, ...
... 2. Ascalaph is general purpose molecular modeling software that performs quantum mechanics calculations for initial molecular model development, molecular mechanics and dynamics simulations in the gas or in condensed phase. It can interact with external molecular modeling packages (MDynaMix, NWChem, ...