Ligand-binding domain
... SRC-1/NCoA-1 family [steroid receptor coactivator 1 / nuclear receptor coactivator 1] TIF2/GRIP1/NCoA-2 [trx.intermed. factor /glucocort. recept. interact.prot / nuclear receptor coactivator 2] pCIP/ACTR/AIB1 [p300/CBP-cointegr. ass. prot. / activator TR and RAR / amplified in ...
... SRC-1/NCoA-1 family [steroid receptor coactivator 1 / nuclear receptor coactivator 1] TIF2/GRIP1/NCoA-2 [trx.intermed. factor /glucocort. recept. interact.prot / nuclear receptor coactivator 2] pCIP/ACTR/AIB1 [p300/CBP-cointegr. ass. prot. / activator TR and RAR / amplified in ...
Acid Carboxypeptidases: Their Occurrence in Plants, Intracellular
... which has not passed through further development) and of the Angiosperms. Carboxypeptidase activity, finally, is present in the thermophilic fungi Talaromyces duponti (Ascomycetes) Humicula lanuginosa (Deuteromycetes); these enzymes, however, belong to a different family of alkaline carboxypeptidase ...
... which has not passed through further development) and of the Angiosperms. Carboxypeptidase activity, finally, is present in the thermophilic fungi Talaromyces duponti (Ascomycetes) Humicula lanuginosa (Deuteromycetes); these enzymes, however, belong to a different family of alkaline carboxypeptidase ...
Slide 1
... • H2 – stimulates gastric parietal cell acid secretion. • H3 – downregulation of histamine release. ...
... • H2 – stimulates gastric parietal cell acid secretion. • H3 – downregulation of histamine release. ...
Apoptosis
... 3. Bcl-2/-XL can recruit ced-4 and its mammalian homolg, Apaf-1 to the mitochondrial membrane. This may prevent ced-4/Apaf-1 from activating caspases, thereby inhibiting apoptosis. 4. Mitochondial proteins, when leaked into the cytosol, are capable of inducing apoptosis. During apoptosis, cytochrome ...
... 3. Bcl-2/-XL can recruit ced-4 and its mammalian homolg, Apaf-1 to the mitochondrial membrane. This may prevent ced-4/Apaf-1 from activating caspases, thereby inhibiting apoptosis. 4. Mitochondial proteins, when leaked into the cytosol, are capable of inducing apoptosis. During apoptosis, cytochrome ...
Characterisation of new intracellular membranes in Escherichia coli
... Under most growth conditions, bacteria maintain a constant of lipid:protein ratio [15], and values of 0.4 are typical of E. coli inner membranes [16]. Proliferation of intracellular membranes upon over-expression of some membrane proteins in E. coli has been reported previously [17^19] indicating th ...
... Under most growth conditions, bacteria maintain a constant of lipid:protein ratio [15], and values of 0.4 are typical of E. coli inner membranes [16]. Proliferation of intracellular membranes upon over-expression of some membrane proteins in E. coli has been reported previously [17^19] indicating th ...
Regulation of Glucose metabolism
... 2. Effect on lipid metabolism: • Affects adipose tissue and causes a reduction in plasma fatty acids A decrease in triglyceride degradation (inhibits hormone sensitive lipase) An increase in triglyceride synthesis by: Increased glucose uptake which is converted into glycerol 3 phosphate Acti ...
... 2. Effect on lipid metabolism: • Affects adipose tissue and causes a reduction in plasma fatty acids A decrease in triglyceride degradation (inhibits hormone sensitive lipase) An increase in triglyceride synthesis by: Increased glucose uptake which is converted into glycerol 3 phosphate Acti ...
HORMONE OF MIDDLE LOBE OF PITUITARY MELANOCYTE
... protrudes into the lumen of rough ER and a signal peptidase of rER membrane hydrolyzes the molecules to split off 25 a.a and thus pre-pro PTH is changed to proPTH having 90 amino acids. PTH: pro-PTH is transferred to rER lumen end moves to Golgi cisternae. A trypsin like enzymes called lipase B hydr ...
... protrudes into the lumen of rough ER and a signal peptidase of rER membrane hydrolyzes the molecules to split off 25 a.a and thus pre-pro PTH is changed to proPTH having 90 amino acids. PTH: pro-PTH is transferred to rER lumen end moves to Golgi cisternae. A trypsin like enzymes called lipase B hydr ...
Supporting Information S1 Metabolic Subsystems How the enzymes
... within the protein matrix channels or along the electrostatic surface of the enzymes belonging to macromolecular complexes [13-14]. In addition, reversible interactions of multienzyme aggregates with structural proteins and membranes are a common occurrence in eukaryotic cells leading to the emerge ...
... within the protein matrix channels or along the electrostatic surface of the enzymes belonging to macromolecular complexes [13-14]. In addition, reversible interactions of multienzyme aggregates with structural proteins and membranes are a common occurrence in eukaryotic cells leading to the emerge ...
Slide 1
... Glycolipids • Carbohydrate attached to a lipid • Some are glycerol based, but most are sphingosine based • Glycosphingolipids • Cerebrosides • Gangliosides ...
... Glycolipids • Carbohydrate attached to a lipid • Some are glycerol based, but most are sphingosine based • Glycosphingolipids • Cerebrosides • Gangliosides ...
Pentose Phosphate Pathway (aka Hexose monophosphate shunt)
... • G6PD is the most regulated enzyme: inhibition by NADPH, expression is dependent on insulin thus it is only expressed at high glucose concentration • Since the non-oxidative pathway is reversible, the direction is dependent on the need of the cell for ATP / acetyl CoA (energy / fatty acid synthesis ...
... • G6PD is the most regulated enzyme: inhibition by NADPH, expression is dependent on insulin thus it is only expressed at high glucose concentration • Since the non-oxidative pathway is reversible, the direction is dependent on the need of the cell for ATP / acetyl CoA (energy / fatty acid synthesis ...
Uncoupling Proteins Cellular Metabolism Cellular Metabolism
... – If high protein/low carb diet ⇒ ↑blood amino acids/↓blood glucose; ⇒ both ↑insulin and ↑glucagon ⇒ ↓blood amino acids without ↓blood glucose ...
... – If high protein/low carb diet ⇒ ↑blood amino acids/↓blood glucose; ⇒ both ↑insulin and ↑glucagon ⇒ ↓blood amino acids without ↓blood glucose ...
Enzymes I - eCurriculum
... Do not follow Michaelis-Menten kinetics (hyperbolic), they show sigmoideal plots Have two or more subunits The substrate binding sites exhibit co-operativity Are modified by reversible non-covalent binding of regulators Allosteric activators lock the enzyme in a conformation that has high affinity f ...
... Do not follow Michaelis-Menten kinetics (hyperbolic), they show sigmoideal plots Have two or more subunits The substrate binding sites exhibit co-operativity Are modified by reversible non-covalent binding of regulators Allosteric activators lock the enzyme in a conformation that has high affinity f ...
Exam Two Review Guide Chapter Five Anabolism vs. Catabolism
... 16. Account for all the ATP, CO2, H2O NADH+H+ and FADH2 generated by one glucose molecule, then again for one G3P molecule. 17. G3P separates the energy investment phase from the energy payoff stage of glycolysis. Why are these phases named as such? 18. We generate between 36-38 ATP in cellular resp ...
... 16. Account for all the ATP, CO2, H2O NADH+H+ and FADH2 generated by one glucose molecule, then again for one G3P molecule. 17. G3P separates the energy investment phase from the energy payoff stage of glycolysis. Why are these phases named as such? 18. We generate between 36-38 ATP in cellular resp ...
Breakdown Industrial Digester PowderTM contains bacteria and
... germinate into growing cells that activate enzyme systems and begin feeding on the available nutrients. OdormuteTM Septic Tank Maintenance contains 5 strains of Bacillus bacteria including 2 bacterial strains which are facultative anaerobes. Facultative Anaerobic bacteria work both with and without ...
... germinate into growing cells that activate enzyme systems and begin feeding on the available nutrients. OdormuteTM Septic Tank Maintenance contains 5 strains of Bacillus bacteria including 2 bacterial strains which are facultative anaerobes. Facultative Anaerobic bacteria work both with and without ...
Structural Biochemistry/Enzyme Regulation
... In the Ping Pong mechanism substrate S binds to the enzyme transferring a chemical component to the active site making a modified enzyme. Once substrate S leaves active site substrate T can bind and react with the newly modified active site. Once the newly formed product leaves the enzyme it return ...
... In the Ping Pong mechanism substrate S binds to the enzyme transferring a chemical component to the active site making a modified enzyme. Once substrate S leaves active site substrate T can bind and react with the newly modified active site. Once the newly formed product leaves the enzyme it return ...
General analysis of observed kinome profiles
... plants. Although its function is less well described in C3 plants such as Arabidopsis, it acts particularly during germination and in providing the TCA/Krebs cycle with intermediates and is activated in response to nitrogen fixation e.g. water stress in C3 plants such as Arabidopsis [22,23]. The red ...
... plants. Although its function is less well described in C3 plants such as Arabidopsis, it acts particularly during germination and in providing the TCA/Krebs cycle with intermediates and is activated in response to nitrogen fixation e.g. water stress in C3 plants such as Arabidopsis [22,23]. The red ...
Lipid Synthesis
... b. Stored and broken down for specific cell needs c. Why do cells go through process of making fatty acids? d. In developed nations, it’s not so critical, but it does occur in two different ways i. De novo synthesis – like making from scratch ii. Carbon lengthening of Palmitic acid and the formation ...
... b. Stored and broken down for specific cell needs c. Why do cells go through process of making fatty acids? d. In developed nations, it’s not so critical, but it does occur in two different ways i. De novo synthesis – like making from scratch ii. Carbon lengthening of Palmitic acid and the formation ...
Human Metabolism: Macronutrients Instructors: Rosalind Coleman
... 261 (organic chemistry) & BIOL 252 (anatomy/physiology) or equivalents. Course Description: My objective is to enable UNC students to understand the relationships between macronutrient biochemistry and metabolism during specific physiological and disease states. We will cover the metabolic and physi ...
... 261 (organic chemistry) & BIOL 252 (anatomy/physiology) or equivalents. Course Description: My objective is to enable UNC students to understand the relationships between macronutrient biochemistry and metabolism during specific physiological and disease states. We will cover the metabolic and physi ...
Chapter 2b Packet
... 5. The starting materials for chemical reactions are called ____________________, while the new substances that are formed are called ____________________. 6. The energy needed to start a chemical reaction is called __________________ ________________. 7. A chemical reaction can be sped up by adding ...
... 5. The starting materials for chemical reactions are called ____________________, while the new substances that are formed are called ____________________. 6. The energy needed to start a chemical reaction is called __________________ ________________. 7. A chemical reaction can be sped up by adding ...
Non-competitive
... active sites in more than 65% of the enzymes studies to date – these five are His > Cys > Asp > Arg > Glu – four these amino acids have either acidic or basic side chains; the fifth has a ...
... active sites in more than 65% of the enzymes studies to date – these five are His > Cys > Asp > Arg > Glu – four these amino acids have either acidic or basic side chains; the fifth has a ...
Proteins - e
... carbohydrates and nucleic acids. They are also important in transporting important neurotransmitters back into the neuron that released them so that the neurotransmitters only have a limited period of activity. The molecules concerned are polar structures and cannot pass through the hydrophobic cell ...
... carbohydrates and nucleic acids. They are also important in transporting important neurotransmitters back into the neuron that released them so that the neurotransmitters only have a limited period of activity. The molecules concerned are polar structures and cannot pass through the hydrophobic cell ...
PP - Chemistry Courses: About
... • Looks allosteric, but this is monomeric enzyme • May be due to conformational change upon product release— stays in active state at high concentration of glucose ...
... • Looks allosteric, but this is monomeric enzyme • May be due to conformational change upon product release— stays in active state at high concentration of glucose ...
BIO-5002A - BIOCHEMISTRY
... a) Facilitated diffusion involves a specific membrane protein that lowers the activation energy for movement of the solute through the membrane b) Facilitated diffusion can increase the magnitude of a transmembrane concentration gradient of the diffusing solute c) Facilitated diffusion is dependent ...
... a) Facilitated diffusion involves a specific membrane protein that lowers the activation energy for movement of the solute through the membrane b) Facilitated diffusion can increase the magnitude of a transmembrane concentration gradient of the diffusing solute c) Facilitated diffusion is dependent ...
Mitochondria
... folded to form cristae. The area of the inner membrane is about five times as great as the outer membrane. • This membrane is richly endowed with cardiolipin, a phospholipid that possesses four, rather than the usual two, fatty acyl chains. The presence of this phospholipid in high concentration mak ...
... folded to form cristae. The area of the inner membrane is about five times as great as the outer membrane. • This membrane is richly endowed with cardiolipin, a phospholipid that possesses four, rather than the usual two, fatty acyl chains. The presence of this phospholipid in high concentration mak ...
inflammatory molecules
... • How are prostaglandins, leukotrienes, lipoxins, and thromboxanes synthesized (substrates, enzymes, cofactors)? • What is the nomenclature for prostaglandin, leukotriene, lipoxin, and thromboxane receptors? • How do NSAIDs work? • How do steroids work? • What are important characteristics of COX-1 ...
... • How are prostaglandins, leukotrienes, lipoxins, and thromboxanes synthesized (substrates, enzymes, cofactors)? • What is the nomenclature for prostaglandin, leukotriene, lipoxin, and thromboxane receptors? • How do NSAIDs work? • How do steroids work? • What are important characteristics of COX-1 ...
Lipid signaling
Lipid signaling, broadly defined, refers to any biological signaling event involving a lipid messenger that binds a protein target, such as a receptor, kinase or phosphatase, which in turn mediate the effects of these lipids on specific cellular responses. Lipid signaling is thought to be qualitatively different from other classical signaling paradigms (such as monoamine neurotransmission) because lipids can freely diffuse through membranes (see osmosis.) One consequence of this is that lipid messengers cannot be stored in vesicles prior to release and so are often biosynthesized ""on demand"" at their intended site of action. As such, many lipid signaling molecules cannot circulate freely in solution but, rather, exist bound to special carrier proteins in serum.