Seminar compendium 2016/2017
... Describe the conversion of pyruvate to fatty acids. Where in the body does it take place, and what is the subcellular localization of the steps? Which steps are regulated and rate-limiting, and what is the mechanism behind the regulation? Fatty acids are not stored as such (why?) but instead as tria ...
... Describe the conversion of pyruvate to fatty acids. Where in the body does it take place, and what is the subcellular localization of the steps? Which steps are regulated and rate-limiting, and what is the mechanism behind the regulation? Fatty acids are not stored as such (why?) but instead as tria ...
Lecture-Lipid Metabolism - Creighton Chemistry Webserver
... Malonyl CoA (fatty acid biosynthesis) not formed, so carnitine acyltransferase I not inhibited Fatty acids enter mitochondria to be degraded to acetyl CoA (which cannot go to TCA because cycle intermediates have been used in gluconeogenesis) Accumulating acetyl CoA accelerates ketone body formation ...
... Malonyl CoA (fatty acid biosynthesis) not formed, so carnitine acyltransferase I not inhibited Fatty acids enter mitochondria to be degraded to acetyl CoA (which cannot go to TCA because cycle intermediates have been used in gluconeogenesis) Accumulating acetyl CoA accelerates ketone body formation ...
Autophosphorylation Activity of the Arabidopsis Ethylene Receptor
... termed phosphorelays. In these pathways the receptors are often hybrid proteins containing a receiver domain at the carboxyl terminus of their kinase domain. After autophosphorylation of the histidine residue in the kinase domain, the phosphoryl group is transferred intra-molecularly to the receiver ...
... termed phosphorelays. In these pathways the receptors are often hybrid proteins containing a receiver domain at the carboxyl terminus of their kinase domain. After autophosphorylation of the histidine residue in the kinase domain, the phosphoryl group is transferred intra-molecularly to the receiver ...
Biochimica et Biophysica Acta
... fimbriae. Immunological studies could help answer the question of whether these similarities are based on structural relationships. The purified protein and antibodies raised against it should enable us to test several parts of our hypothesis that the additional cell envelope protein is (one of) the ...
... fimbriae. Immunological studies could help answer the question of whether these similarities are based on structural relationships. The purified protein and antibodies raised against it should enable us to test several parts of our hypothesis that the additional cell envelope protein is (one of) the ...
Relationship between Protein Synthesis and Secretion in Liver Cells
... into protein in liver cell suspensions in which the adenine nucleotide system was manipulated by adding either fructose, glycerol, rotenone or 2,4-dinitrophenol. The incorporation of L-[1-14C]leucine into protein was lowered by 50% by 4-8 mM fructose, 2-3 mM glycerol, 2-4 fLM rotenone, and 10-30 fLM ...
... into protein in liver cell suspensions in which the adenine nucleotide system was manipulated by adding either fructose, glycerol, rotenone or 2,4-dinitrophenol. The incorporation of L-[1-14C]leucine into protein was lowered by 50% by 4-8 mM fructose, 2-3 mM glycerol, 2-4 fLM rotenone, and 10-30 fLM ...
A critical pocket close to the glutamate binding site of
... mGlu4R. Substituents that bind to this pocket provide an increased potency to the ligand emphasizing the druggability of mGluRs’ orthosteric binding site. Although the size of the pocket is limited, new derivatives may be developed with improved pharmacological properties. It is interesting to note ...
... mGlu4R. Substituents that bind to this pocket provide an increased potency to the ligand emphasizing the druggability of mGluRs’ orthosteric binding site. Although the size of the pocket is limited, new derivatives may be developed with improved pharmacological properties. It is interesting to note ...
Lipid Metabolism - Creighton Chemistry Webserver
... Malonyl CoA (fatty acid biosynthesis) not formed, so carnitine acyltransferase I not inhibited Fatty acids enter mitochondria to be degraded to acetyl CoA (which cannot go to TCA because cycle intermediates have been used in gluconeogenesis) Accumulating acetyl CoA accelerates ketone body formation ...
... Malonyl CoA (fatty acid biosynthesis) not formed, so carnitine acyltransferase I not inhibited Fatty acids enter mitochondria to be degraded to acetyl CoA (which cannot go to TCA because cycle intermediates have been used in gluconeogenesis) Accumulating acetyl CoA accelerates ketone body formation ...
Биохимия жидкостей полости рта
... • The content of calcium ions in the saliva is in the range of 0,75 – 3,0 mmol/l (as in plasma). Calcium can be present in ionized (Ca2 +) or related with protein forms. • Phosphates are in the saliva in the form of free ions hydrogenphosphate and dihydrogenphosphate, which accounts for 70 - 95% of ...
... • The content of calcium ions in the saliva is in the range of 0,75 – 3,0 mmol/l (as in plasma). Calcium can be present in ionized (Ca2 +) or related with protein forms. • Phosphates are in the saliva in the form of free ions hydrogenphosphate and dihydrogenphosphate, which accounts for 70 - 95% of ...
Document
... Using recombinant DNA procedures, it is possible to modify a gene to use a different amino acid in a protein sequence. • Assists in the study of enzyme structure and activity. • Allow for the design of new enzymes and other proteins with desired properties. • The approach can be used for the design ...
... Using recombinant DNA procedures, it is possible to modify a gene to use a different amino acid in a protein sequence. • Assists in the study of enzyme structure and activity. • Allow for the design of new enzymes and other proteins with desired properties. • The approach can be used for the design ...
Type 2 Diabetes
... On carbohydrate metabolism.. Reduces rate of release of glucose from the liver by ...
... On carbohydrate metabolism.. Reduces rate of release of glucose from the liver by ...
eprint_1_29837_493
... denature them. The chemical substances which inactivate the enzymes are called as inhibitors and the process is called enzyme inhibition. Most of the substances commonly referred to as poisons are harmful in that they inhibit one or more essential enzymes. The inhibitors may be classified in two bro ...
... denature them. The chemical substances which inactivate the enzymes are called as inhibitors and the process is called enzyme inhibition. Most of the substances commonly referred to as poisons are harmful in that they inhibit one or more essential enzymes. The inhibitors may be classified in two bro ...
TYK2 (JTK1), Active TYK2 (JTK1), Active
... storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Product shipped ...
... storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Product shipped ...
Rapid increase of cytosolic content of acetyl-CoA
... malonyl-CoA from acetyl-CoA and CO2 which is the ratelimiting step in fatty acid biosynthesis (Wakil et al., 1983; Numa and Tanabe, 1984). Malonyl-CoA serves as a precursor of fatty acid biosynthesis and an intermediate of fatty acid elongation, but it also acts as an allosteric inhibitor of carniti ...
... malonyl-CoA from acetyl-CoA and CO2 which is the ratelimiting step in fatty acid biosynthesis (Wakil et al., 1983; Numa and Tanabe, 1984). Malonyl-CoA serves as a precursor of fatty acid biosynthesis and an intermediate of fatty acid elongation, but it also acts as an allosteric inhibitor of carniti ...
Gq-dependent signalling by the lysophosphatidic acid receptor
... Figure 1 Selective expression of LPA3 receptors and stimulation of Gαq mediated PI hydrolysis, Rho kinase and PKC by LPA in gastric smooth muscle (A) Lysates were prepared from freshly dispersed smooth muscle cells (fsm), cultured smooth muscle cells (csm) and brain (b). The proteins were resolved b ...
... Figure 1 Selective expression of LPA3 receptors and stimulation of Gαq mediated PI hydrolysis, Rho kinase and PKC by LPA in gastric smooth muscle (A) Lysates were prepared from freshly dispersed smooth muscle cells (fsm), cultured smooth muscle cells (csm) and brain (b). The proteins were resolved b ...
Engineering of metabolic pathways by artificial enzyme channels
... or contradictory reactions such as synthesis (anabolism) and degradation (catabolism) or oxidation and reduction to take place within the same cell at the same time. Compartmentation also allows detoxification of toxic pathway intermediates without harming the cell. In peroxisomes, for example, the ...
... or contradictory reactions such as synthesis (anabolism) and degradation (catabolism) or oxidation and reduction to take place within the same cell at the same time. Compartmentation also allows detoxification of toxic pathway intermediates without harming the cell. In peroxisomes, for example, the ...
2008 VFA Absorption
... – 20% of C in palmitate (C16) – 0% of C in C18 • Butyrate – Acetate and B(OH)butyrate contribute equally to the first 4 carbons – Must be converted to acetyl CoA for additional C • Lactate – 5 – 10% of the fatty acids in milk – Inversely related to the amount of acetate available » Controlled by pyr ...
... – 20% of C in palmitate (C16) – 0% of C in C18 • Butyrate – Acetate and B(OH)butyrate contribute equally to the first 4 carbons – Must be converted to acetyl CoA for additional C • Lactate – 5 – 10% of the fatty acids in milk – Inversely related to the amount of acetate available » Controlled by pyr ...
1 2 Resp iratio n : Gly co lysis: TC A -cy cle
... The cellular metabolism is made up of a large number of reactions co-ordinated by enzymes subjected to various control mechanisms. Some of these reactions may lead to a desired product. Knowledge of metabolism and physiology constitutes the basis for developing control strategies in biotechnical pro ...
... The cellular metabolism is made up of a large number of reactions co-ordinated by enzymes subjected to various control mechanisms. Some of these reactions may lead to a desired product. Knowledge of metabolism and physiology constitutes the basis for developing control strategies in biotechnical pro ...
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... their specific carbohydrate moiety, and in the modulation of plasma membrane signal processing. The latter may occur via specific glycosphingolipid-protein interactions (119) or via organizing functions of the glycosphingolipids in signaling domains (118, 202). It should be noted that not only sphin ...
... their specific carbohydrate moiety, and in the modulation of plasma membrane signal processing. The latter may occur via specific glycosphingolipid-protein interactions (119) or via organizing functions of the glycosphingolipids in signaling domains (118, 202). It should be noted that not only sphin ...
Powerpoint
... proenzyme precursor by cleavage specific sites Scheme of procaspase activation:Cleavage of the procaspase at the specific Asp-X bonds leads to the formation of the mature caspase, which comprises the heterotetramer p202– p102, and the release of the prodomain. ...
... proenzyme precursor by cleavage specific sites Scheme of procaspase activation:Cleavage of the procaspase at the specific Asp-X bonds leads to the formation of the mature caspase, which comprises the heterotetramer p202– p102, and the release of the prodomain. ...
A MODEL FOR THE PROTEOLYTIC REGULATION OF
... cell viability (Schakermann et al., 2013); however, very high levels of this enzyme also appear to be toxic to the organism presumably due to a build up of lipid A (Sorensen et al., 1996). Therefore, regulation of LpxC is crucial for microbial survival. In Escherichia coli, LpxC is regulated in a un ...
... cell viability (Schakermann et al., 2013); however, very high levels of this enzyme also appear to be toxic to the organism presumably due to a build up of lipid A (Sorensen et al., 1996). Therefore, regulation of LpxC is crucial for microbial survival. In Escherichia coli, LpxC is regulated in a un ...
Understanding Metabolic Regulation and Its
... makes the ratio of ATP to ADP the relevant parameter in determining whether cells have sufficient energy. The ATP/ ADP ratio is itself buffered by both creatine kinase and adenylate kinases. When demand for ATP is low, the high ATP/ ADP ratio is used to produce creatine-phosphate, which can then reg ...
... makes the ratio of ATP to ADP the relevant parameter in determining whether cells have sufficient energy. The ATP/ ADP ratio is itself buffered by both creatine kinase and adenylate kinases. When demand for ATP is low, the high ATP/ ADP ratio is used to produce creatine-phosphate, which can then reg ...
100 Pectin is a complex polysaccharide consisting mainly of
... sources, maximum enzyme production was observed with Ammonium chloride (inorganic N source) and Beef extract (organic N source), between 72 to 96 hrs. Of the two natural carbon sources tested, the banana peel powder yielded higher enzyme compared to the orange peel powder during the same period. A r ...
... sources, maximum enzyme production was observed with Ammonium chloride (inorganic N source) and Beef extract (organic N source), between 72 to 96 hrs. Of the two natural carbon sources tested, the banana peel powder yielded higher enzyme compared to the orange peel powder during the same period. A r ...
Food Chemistry
... 2.3. Solubility of protein and proteolytic activity Solubility of proteins in protein concentrates obtained from heat drying of raw product and solubility of raw fish muscle were evaluated by quantifying the amount of solubilized protein in the aqueous extracts. The Bradford (1976) method, adapted to ...
... 2.3. Solubility of protein and proteolytic activity Solubility of proteins in protein concentrates obtained from heat drying of raw product and solubility of raw fish muscle were evaluated by quantifying the amount of solubilized protein in the aqueous extracts. The Bradford (1976) method, adapted to ...
Role of Liver In Triglyceride Homeostasis
... • Fox01 gain-of-function is associated with enhanced MTP expression, augmented hepatic VLDL production, and elevated plasma TG levels in Fox01 transgenic mice ...
... • Fox01 gain-of-function is associated with enhanced MTP expression, augmented hepatic VLDL production, and elevated plasma TG levels in Fox01 transgenic mice ...
Lipid signaling
Lipid signaling, broadly defined, refers to any biological signaling event involving a lipid messenger that binds a protein target, such as a receptor, kinase or phosphatase, which in turn mediate the effects of these lipids on specific cellular responses. Lipid signaling is thought to be qualitatively different from other classical signaling paradigms (such as monoamine neurotransmission) because lipids can freely diffuse through membranes (see osmosis.) One consequence of this is that lipid messengers cannot be stored in vesicles prior to release and so are often biosynthesized ""on demand"" at their intended site of action. As such, many lipid signaling molecules cannot circulate freely in solution but, rather, exist bound to special carrier proteins in serum.