- Journal of Hepatology
... liver the source of myriad endogenous metabolites and precursors used by other organs, but also houses a vast array of detoxication enzymes that are crucial for rendering less toxic, more water-soluble and readily excretable the 1–3 million xenobiotics to which we are exposed in our lifetimes [1]. T ...
... liver the source of myriad endogenous metabolites and precursors used by other organs, but also houses a vast array of detoxication enzymes that are crucial for rendering less toxic, more water-soluble and readily excretable the 1–3 million xenobiotics to which we are exposed in our lifetimes [1]. T ...
Glutathione as an endogenous sulphur source in the
... and cysteine biosynthesis. Striking differences were observed in the content of the sulphur amino acids when gshA mutants were compared to wild-type strains growing on the same minimal medium. Furthermore, all mutants examined showed a derepression of y-glutamyltranspeptidase (y-GT), the enzyme init ...
... and cysteine biosynthesis. Striking differences were observed in the content of the sulphur amino acids when gshA mutants were compared to wild-type strains growing on the same minimal medium. Furthermore, all mutants examined showed a derepression of y-glutamyltranspeptidase (y-GT), the enzyme init ...
In vivo contribution of amino acid sulfur to cartilage proteoglycan
... Genetic defects in the metabolism of sulfate causing generalized proteoglycan undersulfation have been described and produce clinical phenotypes of skeletal dysplasia [4a]. Mutations in the DTDST [DTD (diastrophic dysplasia) sulfate transporter; also known as SLC26A2 (solute carrier family 26 member ...
... Genetic defects in the metabolism of sulfate causing generalized proteoglycan undersulfation have been described and produce clinical phenotypes of skeletal dysplasia [4a]. Mutations in the DTDST [DTD (diastrophic dysplasia) sulfate transporter; also known as SLC26A2 (solute carrier family 26 member ...
Lipid and fatty acid metabolism in Ralstonia eutropha: relevance for
... (Insomphun et al. 2013). These results suggest that the FadB gene products encoded in the different β-oxidation operons in R. eutropha play different roles in fatty acid metabolism. Recently, another link between β-oxidation and PHA homeostasis has been uncovered. Gene expression studies suggested t ...
... (Insomphun et al. 2013). These results suggest that the FadB gene products encoded in the different β-oxidation operons in R. eutropha play different roles in fatty acid metabolism. Recently, another link between β-oxidation and PHA homeostasis has been uncovered. Gene expression studies suggested t ...
Purification and properties of NADP +-dependent
... A. nidulans enzyme had a turnover number twice that of the A. n&er enzyme at pH 6-0, whereas inhibition by = 45 ~ L vs M 13 p~).It is proposed that both enzymes catalyse in #iuo the reduction of DHA to NADP+ was less (Ki glycerol and that they are regulated by the anabolic reduction charge. ...
... A. nidulans enzyme had a turnover number twice that of the A. n&er enzyme at pH 6-0, whereas inhibition by = 45 ~ L vs M 13 p~).It is proposed that both enzymes catalyse in #iuo the reduction of DHA to NADP+ was less (Ki glycerol and that they are regulated by the anabolic reduction charge. ...
41 Purine and Pyrimidine Metabolism
... The enzyme is also inhibited by the corresponding nucleoside di- and triphosphates, but under cellular conditions, these compounds probably do not play a central role in regulation. The active enzyme is a monomer of 133,000 daltons but is converted to an inactive dimer (270,000 daltons) by binding o ...
... The enzyme is also inhibited by the corresponding nucleoside di- and triphosphates, but under cellular conditions, these compounds probably do not play a central role in regulation. The active enzyme is a monomer of 133,000 daltons but is converted to an inactive dimer (270,000 daltons) by binding o ...
Effect of Alanine-293 Replacement on the Activity, ATP Binding, and
... aminoacylation activity of LeuRS than any of the other substitutions A293D, A293R, A293G, A293I, A293Y and A293F. 293A is only involved in the binding of ATP, and all amino acid substitutions above caused stronger binding of ATP. Moreover, the negative charge at this site, induced by mutation A293D, ...
... aminoacylation activity of LeuRS than any of the other substitutions A293D, A293R, A293G, A293I, A293Y and A293F. 293A is only involved in the binding of ATP, and all amino acid substitutions above caused stronger binding of ATP. Moreover, the negative charge at this site, induced by mutation A293D, ...
Crassulacean Acid Metabolism
... rhythm of daytime closure and night-time opening, malate formation via PEPC serves as a water-saving mechanism of CO2 acquisition, since evaporative demand is low when stomata open for CO2 uptake in the night instead of during the day, and hence, water use efficiency (WUE 5 CO2 fixed:H2O transpired) is ...
... rhythm of daytime closure and night-time opening, malate formation via PEPC serves as a water-saving mechanism of CO2 acquisition, since evaporative demand is low when stomata open for CO2 uptake in the night instead of during the day, and hence, water use efficiency (WUE 5 CO2 fixed:H2O transpired) is ...
Combined therapy with PPARα agonist and l
... Objective: Peroxisome proliferator-activated receptors (PPAR) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily and are key regulators of fatty acid oxidation (FAO) in the heart. Systemic carnitine deficiency (SCD) causes disorders of FAO and induces ...
... Objective: Peroxisome proliferator-activated receptors (PPAR) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily and are key regulators of fatty acid oxidation (FAO) in the heart. Systemic carnitine deficiency (SCD) causes disorders of FAO and induces ...
The Effect of Arsenic on Liver Tissue of Experimental Animals
... Liver is a target organ and primary site of detoxification and is generally the major site of intense metabolism and is therefore prone to various disorders as a consequence of exposure to the toxins of extrinsic as well as intrinsic forms. Liver plays important role in metabolism to maintain energy ...
... Liver is a target organ and primary site of detoxification and is generally the major site of intense metabolism and is therefore prone to various disorders as a consequence of exposure to the toxins of extrinsic as well as intrinsic forms. Liver plays important role in metabolism to maintain energy ...
HEMAGGLUTINATION BY PURIFIED TYPE I ESCHERICHIA
... (3), and Klebsiella (4) has been known for many years. More recently, the gonococcus has been associated with hemagglutination (HA) 1 (5) and, by using purified pili, it has been conclusively demonstrated that these appendages are the hemagglutinin (6). For coliform bacteria, HA has in some instance ...
... (3), and Klebsiella (4) has been known for many years. More recently, the gonococcus has been associated with hemagglutination (HA) 1 (5) and, by using purified pili, it has been conclusively demonstrated that these appendages are the hemagglutinin (6). For coliform bacteria, HA has in some instance ...
Peroxisomes and peroxisomal disorders: The main facts
... The amount of peroxisomes present in a cell results from different processes that can be divided into (a) peroxisome proliferation by division, (b) peroxisome de novo biogenesis, (c) peroxisome inheritance, and (d) peroxisome degradation by pexophagy, an autophagy-related process. The mechanism that ...
... The amount of peroxisomes present in a cell results from different processes that can be divided into (a) peroxisome proliferation by division, (b) peroxisome de novo biogenesis, (c) peroxisome inheritance, and (d) peroxisome degradation by pexophagy, an autophagy-related process. The mechanism that ...
A non-hemorrhagic hybrid heparin/heparan sulfate with
... 3.2. Enzymatic depolimerization The disaccharide composition of the shrimp H/HS was determined by enzymatic depolymerization with a mixture of heparinase and heparitinases I and II from Flavobacterium heparinum. Upon the combined action of these enzymes, shrimp H/HS yielded a high content of disulfa ...
... 3.2. Enzymatic depolimerization The disaccharide composition of the shrimp H/HS was determined by enzymatic depolymerization with a mixture of heparinase and heparitinases I and II from Flavobacterium heparinum. Upon the combined action of these enzymes, shrimp H/HS yielded a high content of disulfa ...
Human Hepatic d-Aminolaevulinate Synthase
... of hepatic inflammation as judged biochemically and histologically. 5. Cirrhotic subjects excreted more uro- and copro-porphyrin than control subjects, whereas subjects ingesting anticonvulsantsexcreted more 6-aminolaevulinic acid and porphobilinogen than control subjects. However, these increases w ...
... of hepatic inflammation as judged biochemically and histologically. 5. Cirrhotic subjects excreted more uro- and copro-porphyrin than control subjects, whereas subjects ingesting anticonvulsantsexcreted more 6-aminolaevulinic acid and porphobilinogen than control subjects. However, these increases w ...
Vitamins and Coenzymes
... • When this proton dissociates a carbanion is formed which readily undergoes nucleophilic addition to a-carbonyl groups • The carbanion readily adds to carbonly groups, and the thiazolium ring acts as electron sink that stabilizes the negative charge that is transferred to the ring ...
... • When this proton dissociates a carbanion is formed which readily undergoes nucleophilic addition to a-carbonyl groups • The carbanion readily adds to carbonly groups, and the thiazolium ring acts as electron sink that stabilizes the negative charge that is transferred to the ring ...
Development, validation and biological application of
... people to whom I owe a great deal of gratitude. It is difficult to surmise the contribution these people have given me throughout the years but I will try. Under the supervision of Dr. Shawn Burgess I have learned a great deal about what it really means to do science. His candid mentorship is someth ...
... people to whom I owe a great deal of gratitude. It is difficult to surmise the contribution these people have given me throughout the years but I will try. Under the supervision of Dr. Shawn Burgess I have learned a great deal about what it really means to do science. His candid mentorship is someth ...
... (P-5-C) from glutamate or proline (Figure 1). However, the expression of all the enzymes necessary for the synthesis of Arg is restricted to the liver and the intestine mucosa, where citrulline is formed by the action of P-5-C synthetase and ornithine aminotransferase, which can be immediately conve ...
DECALEPIS HAMILTONII ACETAMINOPHEN-INDUCED HEPATIC INJURY IN RATS Research Article
... cellular membrane lipids can lead to cellular necrosis and is now accepted to be important in connection with a variety of pathological conditions3. Reactive oxygen species (ROS), from both endogenous and exogenous, are implicated in the etiology of several degenerative diseases, such as coronary ar ...
... cellular membrane lipids can lead to cellular necrosis and is now accepted to be important in connection with a variety of pathological conditions3. Reactive oxygen species (ROS), from both endogenous and exogenous, are implicated in the etiology of several degenerative diseases, such as coronary ar ...
Couchioplanes caeruleus - International Journal of Systematic and
... Morphological observations. Actinoplanes caeruleus I F 0 13939T, “Actinoplanes azureus” I F 0 13993T, and isolate RA 335 developed branched aerial mycelia. Spores were formed in chains. Sporangia were not observed. The spore chains and aerial mycelia often aggregated into clusters resembling sporang ...
... Morphological observations. Actinoplanes caeruleus I F 0 13939T, “Actinoplanes azureus” I F 0 13993T, and isolate RA 335 developed branched aerial mycelia. Spores were formed in chains. Sporangia were not observed. The spore chains and aerial mycelia often aggregated into clusters resembling sporang ...
Fritz Lipmann - Nobel Lecture
... Fig. 3. Acetyl phosphate as acetyl and phosphoryl donor. there towards a general concept of transfer of activated groupings by carrier as the fundamental reaction in biosynthesis8,9. Although in the related manner the appearance of acetyl phosphate as a metabolic intermediary first focussed attentio ...
... Fig. 3. Acetyl phosphate as acetyl and phosphoryl donor. there towards a general concept of transfer of activated groupings by carrier as the fundamental reaction in biosynthesis8,9. Although in the related manner the appearance of acetyl phosphate as a metabolic intermediary first focussed attentio ...
Molecular and metabolic changes of cherelle wilt of cacao and its
... USA). Gas chromatography coupled to mass spectrometry was used to measure soluble carbohydrates and organic acids as described by Melnick et al. [10]. Separations were performed with a Supelco SPB50 column (SigmaeAldrich). Peak identification and calibration parameters with the Agilent MSD Chemstatio ...
... USA). Gas chromatography coupled to mass spectrometry was used to measure soluble carbohydrates and organic acids as described by Melnick et al. [10]. Separations were performed with a Supelco SPB50 column (SigmaeAldrich). Peak identification and calibration parameters with the Agilent MSD Chemstatio ...
Metabolism of lactate and sugars by dairy propionibacteria: A
... cheese, for the biological production of propionate and vitamin 812 and have probiotic properties. In ail the se applications, their metabolic activities play a critical role. A complete understanding of propionate fermentation and of the metabolic routes used is therefore necessary. Dairy propionib ...
... cheese, for the biological production of propionate and vitamin 812 and have probiotic properties. In ail the se applications, their metabolic activities play a critical role. A complete understanding of propionate fermentation and of the metabolic routes used is therefore necessary. Dairy propionib ...
1st lecture - International Center for Chemical and Biological
... It is a fact that plants have been relatively extensively studied as sources of bioactive metabolites, but the role of endophytic microbes that reside in the tissues between living plant cells has only recently started receiving attention. The relationships between endophytes and their host plants ...
... It is a fact that plants have been relatively extensively studied as sources of bioactive metabolites, but the role of endophytic microbes that reside in the tissues between living plant cells has only recently started receiving attention. The relationships between endophytes and their host plants ...
and Functions of y-Aminobutyric Acid
... blocked by Ca2+ chelators and CaM antagonists. The hormones a-NAA and kinetin induce dedifferentiation of root tissue (Ford et al., 1996). 15N-NMR studies demonstrated that these changes were accompanied by enhanced GABA and reduced Glu levels. GABA accumulation is accompanied by efflux from the cel ...
... blocked by Ca2+ chelators and CaM antagonists. The hormones a-NAA and kinetin induce dedifferentiation of root tissue (Ford et al., 1996). 15N-NMR studies demonstrated that these changes were accompanied by enhanced GABA and reduced Glu levels. GABA accumulation is accompanied by efflux from the cel ...