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Gregory
Piatetsky-Shapiro PhD
President of KDnuggets
Thursday December 8, 2005
1170 TMCB, 11:00 AM
Microarray Data Mining - Dealing with the Challenges
DNA Microarrays have a potential to revolutionize molecular biology and medicine, leading to
new, more effective, and ultimately personalized drugs and treatments. To realize this potential
we need to overcome a number of challenges for microarray data analysis, including lack of
absolute ground truth and having too few samples compared to too many genes.
Researchers analyzing the same data frequently come up with different classifications and
different sets of marker genes and it is hard to determine who is right without expensive lab
tests. To address these problems we propose several approaches. One is developing and
using best practices methodology for data analysis. Second is integrating additional data,
including medical literature and gene onthology. Third is looking at gene groups, rather than at
individual genes. Finally, we propose the development of a comprehensive synthetic microarray
test suite, which would allow calibration of different methods on different types of data and
determining which methods give the best results.
Biography
Gregory Piatetsky-Shapiro, Ph.D., (www.kdnuggets.com/gps.html) is the President of
KDnuggets, which provides research and consulting services in the areas of data mining,
knowledge discovery, bioinformatics, and business analytics. Gregory is also the Editor and
Publisher of KDnuggetsTM News, the leading newsletter on data mining and knowledge
discovery, and www.KDnuggets.com website, a top-ranked site for data mining and knowledge
discovery, including software, jobs, courses, companies, publications, and more.
Gregory is the founder of Knowledge Discovery in Database (KDD) conference series – he
organized and chaired the first three KDD workshops and later helped convert them into leading
international conferences on data mining. He was elected in 2005 as the chair of ACM SIGKDD,
the leading professional organization for Knowledge Discovery and Data Mining.
Gregory has over 60 publications, including 2 best-selling books and several edited collections
on topics related to data mining and knowledge discovery. He frequently gives invited talks on
topics related to Data Mining and Knowledge Discovery.
Donuts will be provided