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Download Special Seminar Dynamic Control of Dentritic Excitability During Hippocampal Rhythmic Activity
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Health Sciences Center NEW ORLEANS r a n i m e S l Specia euroscience School of Medicine Neuroscience Center of Excellence in N Dynamic Control of Dentritic Excitability During Hippocampal Rhythmic Activity more info [email protected] layout&design e.d. guillot NCE 110110 Dendrites of pyramidal neurons receive about 50000 excitatory and inhibitory synapses. Our lab studies how dendrites integrate synaptic input and transform it into action potential output. Hippocampal theta rhythm is important for encoding and retrieval of memories. During hippocampal theta episodes ensembles of pyramidal neurons receive synchronized excitatory input causing them to discharge at 4-12Hz. We found that dendritic integration during repetitive and synchronized hippocampal activity is a highly dynamic process. Neurons control their dendritic excitability by tuning the availability of Stefan Remy, M.D. voltage-gated ion channels on their surface. As Research Group Leader a result the input history of a dendritic branch Dendritic Pathophysiology Lab determines its excitability. At the same time German Center for hippocampal interneurons respond to the activity Neurodegenerative Diseases of the pyramidal neuron population and inhibit (DZNE) dendritic excitability. We find that interneurons of and Department of Epileptology, the CA1 hippocampal subfield can be separated University of Bonn Medical Center into two functional groups according to their theta Bonn, Germany response. The activity of one group attenuates 12:00 p.m. strongly during short theta episodes while the November 18, 2010 activity of the other group increases. Interestingly, both groups have specialized axonal innervation 8th Floor zones on CA1 pyramidal neuron dendrites allowing a dynamic interplay of excitation and inhibition Neuroscience Center which may determine when and where synaptic of Excellence Conference Room plasticity will occur during theta.