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Ciencia Ergo Sum
ISSN: 1405-0269
[email protected]
Universidad Autónoma del Estado de México
México
Rivera Mulia, Juan Carlos; Aranda Anzaldo, Armando
Estructura y función de la unidad fundamental de replicación del DNA (el replicón) en
eucariontes
Ciencia Ergo Sum, vol. 15, núm. 3, noviembre-febrero, 2008, pp. 269-286
Universidad Autónoma del Estado de México
Toluca, México
Available in: http://www.redalyc.org/articulo.oa?id=10415305
Abstract
dna replication is necessary for the transmission of genetic information and thus such a process must achieve accurate copying of
the genome. Since the last century the replicon model has been proposed in order to explain the general mechanism of genome
duplication in bacteria. Later work in yeast lead to identifying proteins and dna sequences that participate in the initiation of
replication in a similar fashion to what has been observed in prokaryotes. This led to attempts for generalizing the replicon model to
eukaryotes. Several key factors involved in replication and conserved from yeast to man have been described to date. However, as
yet, it is not understood how are determined the sites for the start of replication nor the structure of actual replicons in metazoans.
In this article it is suggested that the topological organization of dna within the cell nucleus determines the structure and function of
replicons in higher eukaryotes.
Keywords
chromatin, dna loops, nuclear
matrix, mars, dna orc.
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