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Ciencia Ergo Sum
ISSN: 1405-0269
[email protected]
Universidad Autónoma del Estado de México
México
Díaz Hernández, Verónica; Merchant Larios, Horacio
Bases moleculares de la determinación sexual en mamíferos
Ciencia Ergo Sum, vol. 15, núm. 3, noviembre-febrero, 2008, pp. 287-296
Universidad Autónoma del Estado de México
Toluca, México
Available in: http://www.redalyc.org/articulo.oa?id=10415306
Abstract
Our aim is to correlate classical concepts of sexual differentiation with current molecular mechanisms of sex determination in
mammals. Josts paradigm established that sex determination depends upon endocrine activity of fetal testis. The establishment of
a complex network of alternative molecular pathways of gene expression determines the formation of either ovaries or testis from
undifferentiated gonads. Taking the mouse as a model system, we described the finding of several genes that are regulated
following the expression of Sry in males and the alternate pathways found in females. We concluded that it remains to be known
whether the data from the mouse model could be extended to other mammals, including humans.
Keywords
sex differentiation, sex
determination, gonad, ovary, testis.
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