Download Leukaemia Section t(13;19)(q14;p13) Atlas of Genetics and Cytogenetics

Atlas of Genetics and Cytogenetics
in Oncology and Haematology
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Leukaemia Section
Short Communication
t(13;19)(q14;p13)
Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
(JLH)
Published in Atlas Database: August 2011
Online updated version : http://AtlasGeneticsOncology.org/Anomalies/t1319q14p13ID1512.html
DOI: 10.4267/2042/47270
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence.
© 2012 Atlas of Genetics and Cytogenetics in Oncology and Haematology
cell commitment, and differentiation. Role in epithelial
mesenchymal transition (review in Slattery et al.,
2008).
Clinics and pathology
Disease
B cell acute lymphoblastic leukemia (B-ALL)
Note
An apparently identical t(13;19)(q14;p13) has been
described in 3 cases of chronic lymphocytic leukemia
(CLL) (Finn et al., 1998; Merup et al., 1998; Brown et
al., 1993).
References
Brown AG, Ross FM, Dunne EM, Steel CM, Weir-Thompson
EM. Evidence for a new tumour suppressor locus (DBM) in
human B-cell neoplasia telomeric to the retinoblastoma gene.
Nat Genet. 1993 Jan;3(1):67-72
Finn WG, Kay NE, Kroft SH, Church S, Peterson LC.
Secondary abnormalities of chromosome 6q in B-cell chronic
lymphocytic leukemia: a sequential study of karyotypic
instability in 51 patients. Am J Hematol. 1998 Nov;59(3):223-9
Epidemiology
Only one case to date of ALL with this translocation, a
19-year-old female patient with pre-B-ALL; she
achieved complete remission and (CR) was in
continuing CR 10 months later, at last follow up
(Barber et al., 2007).
Inukai T, Inaba T, Ikushima S, Look AT. The AD1 and AD2
transactivation domains of E2A are essential for the
antiapoptotic activity of the chimeric oncoprotein E2A-HLF. Mol
Cell Biol. 1998 Oct;18(10):6035-43
Merup M, Jansson M, Corcoran M, Liu Y, Wu X, Rasool O,
Stellan B, Hermansson M, Juliusson G, Gahrton G, Einhorn S.
A FISH cosmid 'cocktail' for detection of 13q deletions in
chronic lymphocytic leukaemia--comparison with cytogenetics
and Southern hybridization. Leukemia. 1998 May;12(5):705-9
Genes involved and proteins
Note
The translocation involves TCF3 and an unknown
partner.
Barber KE, Harrison CJ, Broadfield ZJ, Stewart AR, Wright SL,
Martineau M, Strefford JC, Moorman AV. Molecular
cytogenetic
characterization
of
TCF3
(E2A)/19p13.3
rearrangements in B-cell precursor acute lymphoblastic
leukemia. Genes Chromosomes Cancer. 2007 May;46(5):47886
TCF3
Location
19p13.3
Protein
The E2A gene encodes two distinct basic helix-loophelix transcription factors, E12 (ITF1) and E47 (TCF3)
through alternative splicing. It forms homodimers and
heterodimers with other basic helix-loop-helix
transcription factors. Ubiquitously expressed during
development. Role in cell growth,
Atlas Genet Cytogenet Oncol Haematol. 2012; 16(1)
Slattery C, Ryan MP, McMorrow T. E2A proteins: regulators of
cell phenotype in normal physiology and disease. Int J
Biochem Cell Biol. 2008;40(8):1431-6
This article should be referenced as such:
Huret JL. t(13;19)(q14;p13). Atlas Genet Cytogenet Oncol
Haematol. 2012; 16(1):48.
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