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Download Leukaemia Section t(9;11)(q34;p15) Atlas of Genetics and Cytogenetics in Oncology and Haematology
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Atlas of Genetics and Cytogenetics in Oncology and Haematology OPEN ACCESS JOURNAL AT INIST-CNRS Leukaemia Section Short Communication t(9;11)(q34;p15) Jean-Loup Huret Genetics, Dept Medical Information, UMR 8125 CNRS, University of Poitiers, CHU Poitiers Hospital, F86021 Poitiers, France (JLH) Published in Atlas Database: January 2005 Online updated version : http://AtlasGeneticsOncology.org/Anomalies/t0911q34p15ID1380.html DOI: 10.4267/2042/38159 This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence. © 2005 Atlas of Genetics and Cytogenetics in Oncology and Haematology Clinics and pathology Protein Class II homeobox gene. Disease NUP98 Acute myelomonocytic leukemia (M4 ANLL). Location 11p15.4 Protein Nucleoporin 98, a 98 kDa component of the nuclear pore complex implicated in nucleo-cytoplasmic transport. Etiology This leukemia case is likely to be treatment related (a lymphoma was treated 4 years previously). Epidemiology Only one case to date: a 65-year-old female patient. Prognosis Result of the chromosomal anomaly No data. Genes involved and proteins Hybrid gene PRRX2 Description 5'--> exon 11 of NUP98 is fused in frame with PRRX2 exon 2 to 3'. Location 9q34 Atlas Genet Cytogenet Oncol Haematol. 2005; 9(1) 37 t(9;11)(q34;p15) Huret JL References This article should be referenced as such: Huret JL. t(9;11)(q34;p15). Atlas Genet Cytogenet Oncol Haematol. 2005; 9(1):37-38. Gervais C, Mauvieux L, Perrusson N, Hélias C, Struski S, Leymarie V, Lioure B, Lessard M. A new translocation t(9;11)(q34;p15) fuses NUP98 to a novel homeobox partner gene, PRRX2, in a therapy-related acute myeloid leukemia. Leukemia. 2005 Jan;19(1):145-8 Atlas Genet Cytogenet Oncol Haematol. 2005; 9(1) 38
