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6/9/2014 How the Human Body Communicates with Itself Two of the 11 human body systems are involved with control of the body: The NERVOUS SYSTEM ◦ Uses a combination of electrical and chemical signals to communicate information along specialized cells (neurons). The ENDOCRINE SYSTEM The nervous system consists of your brain, spinal cord, and a large network of nerves that branch throughout your body. ◦ Glands secrete chemicals (hormones) in the bloodstream to communicate information to target cells. Neurons are the cells that carry messages between parts of the body. ◦ A nerve is a bundle of neurons. Sensory neurons carry messages to the brain from the body. Motor neurons carry messages from the brain to the body. Interneurons connect motor and sensory neurons. Most of the neuron is the cell body. From the cell body are many branched extensions called dendrites. ◦ Dendrites carry nerve impulses to the cell body. Neurons have a long fiber that carries impulses from the cell to another – this is called an axon. The cell remains at resting potential until a stimulus reaches the cell, either from another neuron or the environment. Channels in the membrane open to allow Na+ ions to enter the cell. The inside of the cell temporarily becomes more positive. This is called the action potential. Refer to fig. 35-7, pg. 899. A resting neuron uses active transport to pump sodium (Na+) ions out of the cell and pump potassium (K+) into the cell. K+ ions also naturally leak across the membrane more easily than Na+ ions. This process creates the resting potential – a net electrical difference across the cell membrane. There is a positive charge outside the axon and a negative charge inside. Soon after the action potential passes a point on the axon, the cell returns to resting potential and is ready to receive another impulse. This is an “all-or-none” process. The following website illustrates the process: http://www.phschool.com/atschool/phbio/active_ar t/nerve_impulse/index.html 1 6/9/2014 Neurons are separated by narrow gaps called synapses. When the action potential reaches the end of the axon it must pass to the next neuron. The neuron before the synapse (pre-synaptic neuron) releases chemicals called neurotransmitters in response to the action potential. The human nervous system is made up of two parts: Central nervous system ◦ Brain and spinal cord Peripheral nervous system ◦ All the other neurons throughout the body Divided into sensory division and motor division. The motor division is further divided: The neurotransmitters find receptacles on the postsynaptic neuron, which then trigger an action potential (AP) in that cell. The cell passes the AP along its own axon, reaching another synapse, which releases neurotransmitters that cross the synapse to the next neuron, etc. The brain has various regions responsible for different functions. Major ones are: ◦ Cerebrum: voluntary actions, judgment, learning. It is divided into two hemispheres. ◦ Cerebellum: coordinates and balances muscles for efficient movement ◦ Brain stem: connects brain and spinal cord; controls involuntary functions like breathing, heart rate, blood pressure, etc. ◦ Thalamus: receiving point for most sensory info. ◦ Hypothalamus: coordinates nervous & endocrine systems Spinal cord: Relays info between brain and rest of body. ◦ Also responsible for reflexive actions. ◦ Somatic system: regulates activities under conscious control & reflex arcs ◦ Autonomic system: controls organ systems not under conscious control. While the nervous system functions like a landline telephone system with specific receivers of information, the endocrine system is used to communicate with many receivers at the same time, like a radio broadcast. 2 6/9/2014 The endocrine system uses chemicals released into the blood (hormones) to communicate between parts of the body. An organ that releases hormones is called a gland. The gland releases the hormones into the blood stream so they can then reach the target cells. Target cells have receptors on their cell membranes for the hormone. Parathyroids: Four glands that work with the thyroid gland to manage calcium levels in the body (important for many processes) Adrenals: Glands on top of each kidney that prepare the body to deal with stress. ◦ Responsible for the “fight-or-flight” response. The endocrine system is managed by feedback mechanisms. It is responsible for controlling metabolism, maintaining water balance, reproductive systems, and many other important functions in the body. Reproductive glands: AKA gonads; responsible for producing gametes (sperm and eggs) as well as sex hormones. Pituitary: Secretes hormones that regulate many body functions, including the function of other endocrine glands. Hypothalamus: Controls pituitary function; handles interaction of endocrine and nervous systems. Thyroid: Regulates body’s metabolism. ◦ Ovaries: produce estrogen and progesterone. ◦ Testes: produce testosterone. Pancreas: Secrete the hormones insulin and glucagon, for managing blood sugar levels. Refer to text sections 35-2 & 35-3 for nervous system info. Refer to text sections 39-1 & 39-2 for endocrine system info. 3