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Transcript
Host Defense and Blood Course Co- Leaders: Leslie Berg, PhD and Robert Weinstein, MD Foundations of Medicine I: Spring Semester, 62 hours {excluding student and course assessment time} A Note from Course Leadership: This course will provide an integrated overview of blood and its disorders (hematology), immunology and inflammation. It will incorporate several new features including on-line learning modules, virtual microscopy exercises and student-led clinical case discussions and problem-solving sessions. Our specific focus is on building student knowledge of the interactions between the blood, immune and inflammatory systems and using this information in conjunction with clinical data to identify important hematological and immunological disorders. Course Overview: The course will be organized into two major sections: Blood and Host Defenses. Each section will include a focus on the normal development, structure and function of the key components of these systems followed by a survey of the major disorders affecting them. The course will primarily address these competencies: physician as scientist and physician as clinical problem solver. Scope of Content: Blood: Bone marrow: normal and abnormal hematopoiesis Peripheral Blood Red blood cells: normal structure and function, disorders, introduction to transfusion medicine White blood cells: normal structure and function, disorders, progenitor cell transplantation Platelets: primary hemostasis, platelet hematology, platelet transfusion Plasma proteins and coagulation cascade: concepts, regulation, anticoagulation, coagulation disorders, plasma products and derivatives Host Defenses: Inflammatory response: cells, soluble factors, vascular response, chronic inflammation Innate immune response: cells, soluble factors, immune receptors, response to infectious agents Adaptive immune response: antibody structure and function; B cells - development, activation and differentiation, malignancies; T cells - antigen presentation, T cell development and functions, T cells in disease - leprosy, autoimmune diseases, malignancy, tumor immunology; hypersensitivity reactions Connections to Other Courses: This course will be closely coordinated with the Infections course, which will occur simultaneously, and there will be critical links with content presented in other FOM1 courses, including Working Cells and Tissues, Genetics, Principles of Pharmacology, and Cancer Concepts. It is anticipated that clinical material presented in this course will have links with the Doctoring course and Integrated Clinical Exercises (ICE) program. Educational Methodologies: We plan to use the following new teaching methods: on-line learning modules and self-assessment quizzes, on-line virtual office hours and chat rooms, small group student-run clinical problem solving sessions, clinical cases requiring integration of hematology and immunology material, in class feedback on material and clinical problem solving using audience response system (clickers). Small groups will be facilitated by up to 20 faculty during small group case study discussion sessions. Student Assessment: Methods Planned: Formative: on-line self-assessment quizzes, use of audience response system during didactic lectures; no in-class time required Evaluative: on-line graded quizzes following clinical case study discussions, in-class midterms and final exam; 4-6 hrs in class time required