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ARIAD Pharmaceuticals, Inc. Title/Position: Senior Research/Staff Scientist in Protein Biochemistry & Molecular Biology Summary ARIAD Pharmaceuticals Inc is seeking an independent and highly motivated scientist with a strong background in molecular biology, protein biochemistry and structural chemistry to join our pre-clinical small molecule oncology drug discovery team. The successful candidate will play a key role in expanding ARIAD’s capability and platform in structure-based drug design and will join an interdisciplinary research group encompassing biochemical assay, structural chemistry (X-ray and NMR), computational chemistry and cheminformatics to support our internal drug discovery efforts. Duties and Responsibilities Design and make protein expression constructs in various protein expressing systems Grow cells in large scale (baculovirus, insect and bacteria) to express protein Purify protein to support biochemical and biophysical studies and structural chemistry (crystallography and NMR) Characterize purified protein, protein-protein and protein:inhibitor complexes Participate in design and optimization of novel enzymatic and biophysical assays. Experience and Requirement Ph.D. with at least 3 years of academic or industrial experience Experience in protein expression in bacteria and baculovirus/insect cells Experience in protein purification and characterization Additional knowledge and experience in structural biology, enzymology and biophysical assays e.g. SPR are welcome Good communication and teamwork skills