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Structure of a typical picornavirus. A: Exploded diagram showing internal location of the RNA genome surrounded by capsid composed of pentamers of
proteins VP1, VP2, VP3, and VP4. Note the “canyon“ depression surrounding the vertex of the pentamer. B: Binding of cellular receptor to the floor of the
canyon. The major rhinovirus receptor (intercellular adhesion molecule-1 [ICAM-1]) has a diameter roughly half that of an immunoglobulin G (IgG) antibody
molecule. C: Location of a drug-binding site in VP1 of a rhinovirus. The antiviral drug shown, WIN 52084, prevents viral attachment by deforming part of
the canyon floor. (Reproduced with permission from Rueckert RR: Picornaviridae: The viruses and their replication. In Fields BN, Knipe DM, Howley PM
[editors-in-chief]. Fields Virology, 3rd ed. Lippincott-Raven, 1996.)
Source: Picornaviruses (Enterovirus and Rhinovirus Groups), Jawetz, Melnick, & Adelberg’s Medical Microbiology, 27e
Citation: Carroll KC, Hobden JA, Miller S, Morse SA, Mietzner TA, Detrick B, Mitchell TG, McKerrow JH, Sakanari JA. Jawetz, Melnick, &
Adelberg’s Medical Microbiology, 27e; 2015 Available at: http://mhmedical.com/ Accessed: May 11, 2017
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