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Download Here we can focus directly on the input neurons, the Schaffer
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Herewecanfocusdirectlyontheinputneurons,theSchaffercollateralsendingontheCA1 pyramidalcells.Wenowseeontherighthandsidethisisthewholesynapticcell,noticeweare nowfocusingonthepost-synapticcell.Theearlychangeforexplicitmemorystorageisgoingto haveapullsynaptictargetratherthanapsynaptictarget.TheSchaffercollateralscomein,they releaseglutamatejustaswesawinthesensoryneuronsinaplysia.Theyactontwodifferent kindsofreceptorstoglutamates.AreceptorcalledNMDAreceptor,andareceptorcalledthe AMPAreceptor.UndernormalcircumstancesonlytheAMPAreceptorisactive.Butifyougivea trainofstimuli,theNMDAreceptorbecomesactive,itflexescalcium,itallowscalciumtocome intothecells.Calciumactivatesasecondmessengerkinase,butadifferentonethanacyclic AMPdependentkinase.Acalciumsensitivekinasecalledthecalciumcalmodulindependent proteinkinase.ItactsbyinsertingadditionalAMPAreceptorsintothepost-synapticcell.And thatisthemechanismforshort-termsynapticplasticityinLTPinthehippocampus.Apost synapticmechanisminvolvingCAMkinaseinsertingnewAMPAreceptors.