Download Supplementary Figure Legends

Supplemental Figure Legends
SFigure 1: Histopathology of livers from control neurons- or BEP neurons-transplanted
groups. A representative liver section from an animal treated with control neurons shows
well-differentiated hepatocellular carcinoma with compressed hepatic parenchyma (left).
A representative liver section from an animal with BEP neuronal transplants shows
almost normal liver morphology with mild fibrosis septae (right).
SFigure 2: Representative picture of a back tumor, which developed in some control
neuron transplanted animals following intravenous injection of MADB106 cells in female
F344 rats.
SFigure 3: In vitro release of cAMP at various timepoints from 70 nmol and 350 nmol
dbcAMP attached to nanospheres. N =5.
SFigure 4: Representative photomicrograph of a section of rat brain showing
fluorescently-labeled-nanosphere attached with cAMP (N-cAMP; blue) in the area of 3rd
ventricle. Also, showing many green fluorescent-labeled-BEP neurons within the arcuate
nucleus.
SFigure 5: Effect of nanosphere-delivered dbcAMP (N-cAMP) injection on tyrosine
hydroxylase (TH) and corticotropin-releasing hormone (CRH) levels in the
hypothalamus. (A) Representative photograph of the TH staining. (B) Total count of THpositive neurons in the PVN. (C) Representative photograph of the CRH staining. (D)
Total count of CRH-positive neurons in the arcuate nucleus. 3V= 3rd ventricle. Data were
analyzed using Students’ t-test. * P < 0.05 comparing to control group. N =5.