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The Effects of Predictive Genetic Testing on the Insurance Industry Chris Welter Antioch College One Morgan Place, Yellow Springs Ohio 45387 Background - Polymerase chain reaction (PCR)technology - Ethical debate in the 1990’s - My experience in the insurance industry WHy should my study be done? - 80-90% predictability rate for Colon Cancer - No knowledge of psychological effects - No study of effect on risk-based insurance industry Methods: Psychological TEsting - Prior to Genetic testing, Participants will be screened for anxiety, depression, and general and situational distress (Michie, 2001) - Carriers and non-carriers of the colon cancer gene will be screened again after they have received their results Methods: Risk Assessment - I will Utilize polymerase chain reaction (PCR) technology to generate copies of participant’s genes (Orita et al., 1989) + + + Denaturation - Heated to 94℃ which results in the melting or separation of the double stranded DNA template into two single stranded molecules Annealing - The oligonucleotide primers anneal to or find their complementary sequences on the two single-stranded template strands of DNA. These act as primers for taq polymerase. All of this is done at 60℃ Extension - Taq polymerase adds the nucleotides to make a complementary copy of the DNA template. This is done at 72℃ I will look for mutated MSH2, MLH1, and MSH6 genes Anticipated Results - Cancer gene carriers will not qualify for insurance coverage, or have extremely high premiums - Also, those gene carriers will have increased anxiety, depression, and general and situational distress--Contrary to the findings of (Broadstock et al., 2000) Conclusion - 2 year process - $25,000 budget Questions? Acknowledgements - Justin Wilson and Philip Crawford from Symmetry Financial Group - Brian Kot, Ph.D., Assistant Professor of Environmental Science and Biology