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EMBO conference series: At the joint edge of cellular microbiology & cell biology Villars-sur-Ollon, Switzerland 20 – 25 September 2008 Co-Sponsors Organisers Chair : Gisou van der Goot (EPFL, Switzerland)) Vice-Chair : Ivan Dikic (Goethe University School of Medicine) Scientific Committee Harald Stenmark (Norwegian Radium Hospital) Guy Cornelis (Biozentrum, Basel, Switzerland) Pascale Cossart (Institut Pasteur, Paris, France) Jean Gruenberg (University of Geneva, Switzerland) David Holden (Imperial College, London, UK) Philippe Sansonetti (Institut Pasteur, Paris, France) Michael Way (Cancer Research UK, London, UK) Embo conference series: At the joint edge of cellular microbiology & cell biology Villars-sur-Ollon, Switzerland 20 – 25 September 2008 1 Programme Programme Schedule Saturday 20 September 17:00 Arrival and registration 19:30 Supper 21:00 Get-together-drinks Sunday 21 September Session 1: Temporal control of trafficking events Morning Chair : Harald Stenmark (Norwegian Radium Hospital, Oslo, Norway) 08:50 Opening remarks 09:00 Catherine Rabouille (University Medical Center Utrecht) How integrins trigger their unconventional secretion during epithelium remodeling in Drosophila 09:35 Simona Polo (Istituto FIRC di Oncologia Molecolare, Italy) The role of endocytosis in organizing and complexifying intracellular signalling 10:10 Coen Kuijl (The Netherlands Cancer Institute Tumor Biology, Amsterdam) The molecular mechanism of cholesterol control of late endosomal transport by dynein motors 10:35-11:05 Coffee break 11:05-11:40 Jaime Mota (Imperial College London) Interaction between intracellular Salmonella and post-Golgi trafficking Embo conference series: At the joint edge of cellular microbiology & cell biology Villars-sur-Ollon, Switzerland 20 – 25 September 2008 2 11:40-12:15 Jean Pieters (Biozentrum, Univ. Basel) 'Preventing lysosomal trafficking of pathogenic mycobacteria through modulation of host signal transduction' 12:30 Lunch (speakers available to sit with young investigators) Session 2: Systems biology of cell biology and host-pathogen interactions Afternoon Chair : Jean Gruenberg (University of Geneva) 16:00 Lucas Pelkmans (ETHZ, Switzerland) Towards systems analysis of endocytosis and virus entry in mammalian cells 16:35 Linda Stuart (Harvard, Boston) Systems approaches to phagocytosis 17:10 Barbara Burleigh (Harvard School of Public Health) Global approaches to studying cellular invasion by Trypanosoma cruzi 17:45-18:15 Coffee break 18:15 Keynote lecture : Sponsored by the Journal of Cell Science Pascale Cossart (Institut Pasteur, Paris) Listeria monocytogenesis, a paradigm to study host-pathogen interaction of an intracytoplasmic bacterium 19:30 Dinner (speakers available to sit with young investigators) Embo conference series: At the joint edge of cellular microbiology & cell biology Villars-sur-Ollon, Switzerland 20 – 25 September 2008 3 20:45 Poster session 1 Sponsored by : Embo conference series: At the joint edge of cellular microbiology & cell biology Villars-sur-Ollon, Switzerland 20 – 25 September 2008 4 Monday 22 September Session 3: Unconventional membrane mediated processes Morning Chair : David Holden (Imperial College, London, UK) 09.00 Ludger Johannes (Curie Institute, Paris) Mechanisms of membrane invagination and scission in clathrinindependent endocytosis 09:35 Jean Celli (Rock Mountain Laboratories, NIH, Montana) Intracellular trafficking of Brucella determines temporal expression of virulence genes 10.10 Marc Fivaz (University of Singapore) A model for neuronal polarization based on local positive feedback and membrane transport 10:35-11:05 Coffee break 11:05 Anne Ridley (King’s College London) How cells move through other cells 11:40 Emmanuel Lemichez (University of Nice) Bacterial induced transient macroapertures in endothelial cells 12:30 Lunch (speakers available to sit with young investigators) Embo conference series: At the joint edge of cellular microbiology & cell biology Villars-sur-Ollon, Switzerland 20 – 25 September 2008 5 Session 4: . Pathogens: the ultimate cell biologists Afternoon Chair : Anne Ridley (University College London) 16.00 Vojo Deretic (University of New Mexico School of Medicine, USA) The role of autohagy in mycobacterial infection 16:35 Raffi Aroian (UCSD) Pore worms-- uncovering intrinsic cellular defenses against pore-forming toxins using C. elegans 17:10 Bernd Helms (Dept. Biochem. & Cell Biology, Utrecht University) Lipidome analysis of latex bead phagosome maturation 17:35-18:05 Coffee break 18:05 Volker Heussler (Bernhard Nocht Inst. Tropical Medicine, Hamburg) Manipulation of host hepatocytes by the malaria parasite 18:40 Janet Deane (Sir William Dunn School of Pathology, University of Oxford) Regulating type III secretion: components and complexes 19:30 Dinner (speakers available to sit with young investigators) 20:30 Poster session 2, sponsored by: Embo conference series: At the joint edge of cellular microbiology & cell biology Villars-sur-Ollon, Switzerland 20 – 25 September 2008 6 Tuesday 23 September Session 5: Signalling and anti-signalling Morning Chair: Antonella de Matteis (Consorzio Mario Negri, Italy) 09:00 Kim Orth (University of Texas Southwestern Medical Center, Dallas) Interference with cellular signalling cascades by YOP proteins 09:35 Ivan Dikic (Goethe University School of Medicine, Frankfurt, Germany) Targeting ubiquitin networks 10:10 Lucile Espert (University of Montpellier, France) Cell-to-cell membrane fusion induced by HIV-1 envelope glycoproteins triggers autophagy and cell death in the uninfected CD4 T cells 10:35-11:05 Coffee break 11:05 Valeria Cavalli (Washington University, Saint Louis) The role of axonal transport in mediating long-range biochemical signals 11:40-12:15 Marta Miaczynska (Int. Instit. Mol. and Cell Biology, Warsaw, Poland) Signalling complexes on endosomes 12:30 Lunch (speakers available to sit with young investigators) 14:00 Excursion 19:30 Dinner 20:45 Poster session 3, sponsored by: Embo conference series: At the joint edge of cellular microbiology & cell biology Villars-sur-Ollon, Switzerland 20 – 25 September 2008 7 Wednesday 24 September Session 6: Immune cells and their interaction with pathogens Morning Chair: Pascale Cossart (Pasteur Institute, Paris, France) 9:00 Frances Brodsky (Hooper Foundation, San Franscisco) Endocytosis in the natural killer cell 9:35 Paul Lehner (University of Cambridge, UK) Ubiquitination mediated down regulation of the immune response during viral infection 10:10 Emily Eden (UCL Inst. Ophthalmology Cell Biology) The role of PTP1B-mediated dephosphorylation in regulating EGFR trafficking. 10:45-11:15 Coffee break 11:15 Natalie Strynadka (University of British Columbia, Vancouver) Structural characterization of bacterial type III secretion apparatuses 11:50-12:25 Vincent Piguet (University of Geneva) How HIV hides in dendritic cells 12:30 Lunch (speakers available to sit with young investigators) Embo conference series: At the joint edge of cellular microbiology & cell biology Villars-sur-Ollon, Switzerland 20 – 25 September 2008 8 Session 7: On the generation of tubules and vesicles Afternoon Chair: David Holden (Imperial College London) 16:00 Patricia Bassereau (Institut Curie, Paris) Dynamics and thermodynamics of membrane deformation 16:35 Jean Gruenberg (University of Geneva) Biogenesis and dynamics on intraluminal endosomal membranes 17:10 Guillaume Dumenil (Faculte de medecine Rene Descartes, Paris) Neisseria meningitidis-induced host cell surface reorganization confers mechanical resistance to bacterial microcolonies in the bloodstream 17:35-18:05 Coffee Break 18:05 Harald Stenmark (Norwegian Radium Hospital, Oslo) sorting into multivesicular endosomes 18.40-19:15 Antonella de Matteis (Consorzio Mario Negri, Italy) Role of phosphoinositides in the secretory pathway 19:30 Congress Dinner and Farewell party Poster award ceremony Embo conference series: At the joint edge of cellular microbiology & cell biology Villars-sur-Ollon, Switzerland 20 – 25 September 2008 9 Thursday 25 September Breakfast and Departure Embo conference series: At the joint edge of cellular microbiology & cell biology Villars-sur-Ollon, Switzerland 20 – 25 September 2008 10