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Control of trophic hormone secretion from the adenohypophysis by hypothalamic-releasing hormones (RH) and release-inhibiting hormones (RIH). The
releasing and release-inhibiting hormones are synthesized by neurons in the hypothalamus, transported by axonal processes, and released into capillary
plexus in the median eminence. They are transported to the adenohypophysis by the hypothalamic–hypophyseal portal system, where they interact with
specific populations of trophic hormone-secreting cells to govern the rate of release of preformed hormones, such as growth hormone (GH), somatotropic
hormone (STH), luteotropic hormone (LTH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyrotropic hormone (TTH), adrenocorticotropic
hormone (ACTH), and melanocyte-stimulating hormone (MSH). There are RIHs for those trophic hormones (e.g., prolactin and growth hormone) that do
Source: Toxic Responses of the Endocrine System, Casarett & Doull’s Essentials of Toxicology, 3e
not directly influence the activity of target cells and result in production of a final endocrine product (hormone) that could exert negative feedback control.
Citation: Klaassen CD, Watkins III JB. Casarett & Doull’s Essentials of Toxicology, 3e; 2015 Available at: http://mhmedical.com/ Accessed: May
04, 2017
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