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EMBARGOED UNTIL 00:01 (BST) WEDNESDAY 10 JUNE 2015 RNA-directed epigenetic silencing of Periostin inhibits cell motility Royal Society Open Science We find here that promoter directed small antisense non-coding RNAs (sasRNAs) can induce transcriptional gene silencing (TGS) of Periostin that results ultimately in a loss of cellular motility. The observations presented here suggest that cell motility and possibly metastasis can be controlled by transcriptional and epigenetic regulation of Periostin offering a potentially new and novel manner to control the spread of cancerous cells. Contact: Dr Kevin Morris, University of New South Wales, [email protected], URL after publication: http://rsos.royalsocietypublishing.org/lookup/doi/10.1098/rs os.140545
